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O35118 (GFRA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GDNF family receptor alpha-3
Short name=GDNF receptor alpha-3
Short name=GDNFR-alpha-3
Short name=GFR-alpha-3
Gene names
Name:Gfra3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase By similarity.

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor By similarity.

Sequence similarities

Belongs to the GDNFR family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 371343GDNF family receptor alpha-3
PRO_0000010791
Propeptide372 – 39726Removed in mature form Potential
PRO_0000010792

Amino acid modifications

Lipidation3711GPI-anchor amidated asparagine Potential
Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation1451N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict5 – 62WS → LE in AAC23558. Ref.2
Sequence conflict5 – 62WS → LE in AAC24468. Ref.3
Sequence conflict661S → C in BAC32778. Ref.6
Sequence conflict2181A → P in AAC23558. Ref.2
Sequence conflict2181A → P in AAC24468. Ref.3
Sequence conflict2181A → P in AAB70931. Ref.5
Sequence conflict3141T → S in AAH66202. Ref.7

Sequences

Sequence LengthMass (Da)Tools
O35118 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: BB66CEF65D32A4B9

FASTA39744,307
        10         20         30         40         50         60 
MGLSWSPRPP LLMILLLVLS LWLPLGAGNS LATENRFVNS CTQARKKCEA NPACKAAYQH 

        70         80         90        100        110        120 
LGSCTSSLSR PLPLEESAMS ADCLEAAEQL RNSSLIDCRC HRRMKHQATC LDIYWTVHPA 

       130        140        150        160        170        180 
RSLGDYELDV SPYEDTVTSK PWKMNLSKLN MLKPDSDLCL KFAMLCTLHD KCDRLRKAYG 

       190        200        210        220        230        240 
EACSGIRCQR HLCLAQLRSF FEKAAESHAQ GLLLCPCAPE DAGCGERRRN TIAPSCALPS 

       250        260        270        280        290        300 
VTPNCLDLRS FCRADPLCRS RLMDFQTHCH PMDILGTCAT EQSRCLRAYL GLIGTAMTPN 

       310        320        330        340        350        360 
FISKVNTTVA LSCTCRGSGN LQDECEQLER SFSQNPCLVE AIAAKMRFHR QLFSQDWADS 

       370        380        390 
TFSVVQQQNS NPALRLQPRL PILSFSILPL ILLQTLW

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR-alpha."
Nomoto S., Ito S., Yang L.-X., Kiuchi K.
Biochem. Biophys. Res. Commun. 244:849-853(1998) [PubMed: 9535755] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Heart.
[2]"GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells."
Widenfalk J., Tomac A., Lindqvist E., Hoffer B., Olson L.
Eur. J. Neurosci. 10:1508-1517(1998) [PubMed: 9749804] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor."
Naveilhan P., Baudet C., Mikaels A., Shen L., Westphal H., Ernfors P.
Proc. Natl. Acad. Sci. U.S.A. 95:1295-1300(1998) [PubMed: 9448325] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family."
Baloh R.H., Gorodinsky A., Golden J.P., Tansey M.G., Keck C.L., Popescu N.C., Johnson E.M. Jr., Milbrandt J.
Proc. Natl. Acad. Sci. U.S.A. 95:5801-5806(1998) [PubMed: 9576965] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase."
Trupp M., Raynoschek C., Belluardo N., Ibanez C.F.
Mol. Cell. Neurosci. 11:47-63(1998) [PubMed: 9608533] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Adrenal gland.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB008833 mRNA. Translation: BAA23562.1.
AF041842 mRNA. Translation: AAC23558.1.
AF036163 mRNA. Translation: AAC24468.1.
AF051766 mRNA. Translation: AAC24354.1.
AF020305 mRNA. Translation: AAB70931.1.
AK046542 mRNA. Translation: BAC32778.1.
BC066202 mRNA. Translation: AAH66202.1.
IPIIPI00127451.
PIRJE0082.
RefSeqNP_034410.3. NM_010280.3.
UniGeneMm.16520.

3D structure databases

ProteinModelPortalO35118.
SMRO35118. Positions 155-354.
ModBaseSearch...

Protein-protein interaction databases

STRINGO35118.

Proteomic databases

PRIDEO35118.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025224; ENSMUSP00000025224; ENSMUSG00000024366.
GeneID14587.
KEGGmmu:14587.
UCSCuc008ele.2. mouse.

Organism-specific databases

CTD2676.
MGIMGI:1201403. Gfra3.

Phylogenomic databases

eggNOGroNOG13519.
HOGENOMHBG713385.
HOVERGENHBG051726.
InParanoidO35118.
OMAQDWADST.
OrthoDBEOG45X7W7.
PhylomeDBO35118.

Gene expression databases

ArrayExpressO35118.
BgeeO35118.
GenevestigatorO35118.
GermOnlineENSMUSG00000024366. Mus musculus.

Family and domain databases

InterProIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR003505. GDNF_rcpt_A3.
[Graphical view]
PfamPF02351. GDNF. 3 hits.
[Graphical view]
PRINTSPR01319. GDNFRALPHA3.
PR01316. GDNFRECEPTOR.
SMARTSM00907. GDNF. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio286334.
SOURCESearch...

Entry information

Entry nameGFRA3_MOUSE
AccessionPrimary (citable) accession number: O35118
Secondary accession number(s): O35325 expand/collapse secondary AC list , O55243, Q6NZC2, Q8C8L9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 1, 1998
Last modified: September 21, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents