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Protein

GDNF family receptor alpha-3

Gene

Gfra3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase (By similarity).By similarity

GO - Molecular functioni

  • axon guidance receptor activity Source: MGI
  • coreceptor activity Source: MGI

GO - Biological processi

  • axon guidance Source: MGI
  • neuron development Source: MGI
  • neuron migration Source: MGI
  • sympathetic nervous system development Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-3
Short name:
GDNF receptor alpha-3
Short name:
GDNFR-alpha-3
Short name:
GFR-alpha-3
Gene namesi
Name:Gfra3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1201403. Gfra3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 371343GDNF family receptor alpha-3PRO_0000010791Add
BLAST
Propeptidei372 – 39726Removed in mature formSequence analysisPRO_0000010792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence analysis
Lipidationi371 – 3711GPI-anchor amidated asparagineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO35118.
PRIDEiO35118.

PTM databases

PhosphoSiteiO35118.

Expressioni

Gene expression databases

BgeeiO35118.
GenevisibleiO35118. MM.

Interactioni

Protein-protein interaction databases

BioGridi199906. 1 interaction.
STRINGi10090.ENSMUSP00000025224.

Structurei

3D structure databases

ProteinModelPortaliO35118.
SMRiO35118. Positions 41-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIBW. Eukaryota.
ENOG4111VG4. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000059598.
HOVERGENiHBG051726.
InParanoidiO35118.
OMAiCHRRMKH.
OrthoDBiEOG7FBRJ3.
PhylomeDBiO35118.
TreeFamiTF331647.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR003505. GDNF_rcpt_A3.
[Graphical view]
PfamiPF02351. GDNF. 3 hits.
[Graphical view]
PRINTSiPR01319. GDNFRALPHA3.
PR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSWSPRPP LLMILLLVLS LWLPLGAGNS LATENRFVNS CTQARKKCEA
60 70 80 90 100
NPACKAAYQH LGSCTSSLSR PLPLEESAMS ADCLEAAEQL RNSSLIDCRC
110 120 130 140 150
HRRMKHQATC LDIYWTVHPA RSLGDYELDV SPYEDTVTSK PWKMNLSKLN
160 170 180 190 200
MLKPDSDLCL KFAMLCTLHD KCDRLRKAYG EACSGIRCQR HLCLAQLRSF
210 220 230 240 250
FEKAAESHAQ GLLLCPCAPE DAGCGERRRN TIAPSCALPS VTPNCLDLRS
260 270 280 290 300
FCRADPLCRS RLMDFQTHCH PMDILGTCAT EQSRCLRAYL GLIGTAMTPN
310 320 330 340 350
FISKVNTTVA LSCTCRGSGN LQDECEQLER SFSQNPCLVE AIAAKMRFHR
360 370 380 390
QLFSQDWADS TFSVVQQQNS NPALRLQPRL PILSFSILPL ILLQTLW
Length:397
Mass (Da):44,307
Last modified:January 1, 1998 - v1
Checksum:iBB66CEF65D32A4B9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 62WS → LE in AAC23558 (PubMed:9749804).Curated
Sequence conflicti5 – 62WS → LE in AAC24468 (PubMed:9448325).Curated
Sequence conflicti66 – 661S → C in BAC32778 (PubMed:16141072).Curated
Sequence conflicti218 – 2181A → P in AAC23558 (PubMed:9749804).Curated
Sequence conflicti218 – 2181A → P in AAC24468 (PubMed:9448325).Curated
Sequence conflicti218 – 2181A → P in AAB70931 (PubMed:9608533).Curated
Sequence conflicti314 – 3141T → S in AAH66202 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008833 mRNA. Translation: BAA23562.1.
AF041842 mRNA. Translation: AAC23558.1.
AF036163 mRNA. Translation: AAC24468.1.
AF051766 mRNA. Translation: AAC24354.1.
AF020305 mRNA. Translation: AAB70931.1.
AK046542 mRNA. Translation: BAC32778.1.
BC066202 mRNA. Translation: AAH66202.1.
CCDSiCCDS29133.1.
PIRiJE0082.
RefSeqiNP_034410.3. NM_010280.4.
UniGeneiMm.16520.

Genome annotation databases

EnsembliENSMUST00000025224; ENSMUSP00000025224; ENSMUSG00000024366.
GeneIDi14587.
KEGGimmu:14587.
UCSCiuc008ele.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008833 mRNA. Translation: BAA23562.1.
AF041842 mRNA. Translation: AAC23558.1.
AF036163 mRNA. Translation: AAC24468.1.
AF051766 mRNA. Translation: AAC24354.1.
AF020305 mRNA. Translation: AAB70931.1.
AK046542 mRNA. Translation: BAC32778.1.
BC066202 mRNA. Translation: AAH66202.1.
CCDSiCCDS29133.1.
PIRiJE0082.
RefSeqiNP_034410.3. NM_010280.4.
UniGeneiMm.16520.

3D structure databases

ProteinModelPortaliO35118.
SMRiO35118. Positions 41-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199906. 1 interaction.
STRINGi10090.ENSMUSP00000025224.

PTM databases

PhosphoSiteiO35118.

Proteomic databases

PaxDbiO35118.
PRIDEiO35118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025224; ENSMUSP00000025224; ENSMUSG00000024366.
GeneIDi14587.
KEGGimmu:14587.
UCSCiuc008ele.2. mouse.

Organism-specific databases

CTDi2676.
MGIiMGI:1201403. Gfra3.

Phylogenomic databases

eggNOGiENOG410IIBW. Eukaryota.
ENOG4111VG4. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000059598.
HOVERGENiHBG051726.
InParanoidiO35118.
OMAiCHRRMKH.
OrthoDBiEOG7FBRJ3.
PhylomeDBiO35118.
TreeFamiTF331647.

Miscellaneous databases

NextBioi286334.
PROiO35118.
SOURCEiSearch...

Gene expression databases

BgeeiO35118.
GenevisibleiO35118. MM.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR003505. GDNF_rcpt_A3.
[Graphical view]
PfamiPF02351. GDNF. 3 hits.
[Graphical view]
PRINTSiPR01319. GDNFRALPHA3.
PR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR-alpha."
    Nomoto S., Ito S., Yang L.-X., Kiuchi K.
    Biochem. Biophys. Res. Commun. 244:849-853(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  2. "GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells."
    Widenfalk J., Tomac A., Lindqvist E., Hoffer B., Olson L.
    Eur. J. Neurosci. 10:1508-1517(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor."
    Naveilhan P., Baudet C., Mikaels A., Shen L., Westphal H., Ernfors P.
    Proc. Natl. Acad. Sci. U.S.A. 95:1295-1300(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase."
    Trupp M., Raynoschek C., Belluardo N., Ibanez C.F.
    Mol. Cell. Neurosci. 11:47-63(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Adrenal gland.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiGFRA3_MOUSE
AccessioniPrimary (citable) accession number: O35118
Secondary accession number(s): O35325
, O55243, Q6NZC2, Q8C8L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.