Reviewed, UniProtKB/Swiss-Prot O35118 (GFRA3_MOUSE)

Names and origin

Protein names

Recommended name:
    GDNF family receptor alpha-3
      Short name=GFR-alpha-3

Gene names

Name:

Gfra3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase By similarity.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Sequence similarities	Belongs to the GDNFR family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
Molecular function	Receptor
PTM	GPI-anchor Glycoprotein Lipoprotein
Gene Ontology (GO)
Biological process	axon guidance Inferred from mutant phenotype. Source: MGI neuron migration Inferred from mutant phenotype. Source: MGI sympathetic nervous system development Inferred from mutant phenotype. Source: MGI transmembrane receptor protein tyrosine kinase signaling pathway Traceable author statement. Source: MGI
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell external side of plasma membrane Inferred from direct assay. Source: MGI
Molecular function	axon guidance receptor activity Inferred from mutant phenotype. Source: MGI coreceptor activity Traceable author statement. Source: MGI protein binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 371	343	GDNF family receptor alpha-3		PRO_0000010791
	Propeptide	372 – 397	26	Removed in mature form Potential		PRO_0000010792
Amino acid modifications
	Lipidation	371	1	GPI-anchor amidated asparagine Potential
	Glycosylation	92	1	N-linked (GlcNAc...) Potential
	Glycosylation	145	1	N-linked (GlcNAc...) Potential
	Glycosylation	306	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	5 – 6	2	WS → LE Ref.2
	Sequence conflict	5 – 6	2	WS → LE Ref.3
	Sequence conflict	66	1	S → C in BAC32778. Ref.6
	Sequence conflict	218	1	A → P Ref.2
	Sequence conflict	218	1	A → P Ref.3
	Sequence conflict	218	1	A → P Ref.5
	Sequence conflict	314	1	T → S in AAH66202. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	O35118-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: BB66CEF65D32A4B9	FASTA	397	44,307
	10 20 30 40 50 60 MGLSWSPRPP LLMILLLVLS LWLPLGAGNS LATENRFVNS CTQARKKCEA NPACKAAYQH 70 80 90 100 110 120 LGSCTSSLSR PLPLEESAMS ADCLEAAEQL RNSSLIDCRC HRRMKHQATC LDIYWTVHPA 130 140 150 160 170 180 RSLGDYELDV SPYEDTVTSK PWKMNLSKLN MLKPDSDLCL KFAMLCTLHD KCDRLRKAYG 190 200 210 220 230 240 EACSGIRCQR HLCLAQLRSF FEKAAESHAQ GLLLCPCAPE DAGCGERRRN TIAPSCALPS 250 260 270 280 290 300 VTPNCLDLRS FCRADPLCRS RLMDFQTHCH PMDILGTCAT EQSRCLRAYL GLIGTAMTPN 310 320 330 340 350 360 FISKVNTTVA LSCTCRGSGN LQDECEQLER SFSQNPCLVE AIAAKMRFHR QLFSQDWADS 370 380 390 TFSVVQQQNS NPALRLQPRL PILSFSILPL ILLQTLW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR-alpha." Nomoto S., Ito S., Yang L.-X., Kiuchi K. Biochem. Biophys. Res. Commun. 244:849-853(1998) [PubMed: 9535755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Heart.
[2]	"GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells." Widenfalk J., Tomac A., Lindqvist E., Hoffer B., Olson L. Eur. J. Neurosci. 10:1508-1517(1998) [PubMed: 9749804] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor." Naveilhan P., Baudet C., Mikaels A., Shen L., Westphal H., Ernfors P. Proc. Natl. Acad. Sci. U.S.A. 95:1295-1300(1998) [PubMed: 9448325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family." Baloh R.H., Gorodinsky A., Golden J.P., Tansey M.G., Keck C.L., Popescu N.C., Johnson E.M. Jr., Milbrandt J. Proc. Natl. Acad. Sci. U.S.A. 95:5801-5806(1998) [PubMed: 9576965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase." Trupp M., Raynoschek C., Belluardo N., Ibanez C.F. Mol. Cell. Neurosci. 11:47-63(1998) [PubMed: 9608533] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Adrenal gland.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB008833 mRNA. Translation: BAA23562.1. AF041842 mRNA. Translation: AAC23558.1. AF036163 mRNA. Translation: AAC24468.1. AF051766 mRNA. Translation: AAC24354.1. AF020305 mRNA. Translation: AAB70931.1. AK046542 mRNA. Translation: BAC32778.1. BC066202 mRNA. Translation: AAH66202.1.
IPI	IPI00127451.
PIR	JE0082.
RefSeq	NP_034410.3.
UniGene	Mm.16520
3D structure databases
SMR	O35118. Positions 155-354.
ModBase	Search...
Protein-protein interaction databases
STRING	O35118.
Proteomic databases
PRIDE	O35118.
Genome annotation databases
Ensembl	ENSMUST00000025224; ENSMUSP00000025224; ENSMUSG00000024366; Mus musculus. [Genome view]
GeneID	14587.
KEGG	mmu:14587.
UCSC	uc008ele.1. mouse.
Organism-specific databases
CTD	14587.
MGI	MGI:1201403. Gfra3.
Phylogenomic databases
HOGENOM	O35118.
HOVERGEN	O35118.
OMA	QDWADST.
Gene expression databases
ArrayExpress	O35118.
Bgee	O35118.
Genevestigator	O35118.
GermOnline	ENSMUSG00000024366. Mus musculus.
Family and domain databases
InterPro	IPR016017. GDNF/GAS1. IPR003438. GDNF_rcpt. IPR003505. GDNF_rcpt_A3. [Graphical view]
Pfam	PF02351. GDNF. 3 hits. [Graphical view]
PRINTS	PR01319. GDNFRALPHA3. PR01316. GDNFRECEPTOR.
ProtoNet	Search...
Other Resources
NextBio	286334.
SOURCE	Search...

Entry information

Entry name

GFRA3_MOUSE

Accession

Primary (citable) accession number: O35118
Secondary accession number(s): O35325 , O55243, Q6NZC2, Q8C8L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)