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Protein

Catenin delta-2

Gene

Ctnnd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (By similarity).By similarity2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin delta-2
Gene namesi
Name:Ctnnd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620734. Ctnnd2.

Subcellular locationi

GO - Cellular componenti

  • adherens junction Source: UniProtKB-SubCell
  • dendrite Source: UniProtKB-SubCell
  • neuron projection Source: RGD
  • nucleus Source: RGD
  • perikaryon Source: UniProtKB
  • postsynaptic density Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000064301‹1 – ›264Catenin delta-2Add BLAST›264

Post-translational modificationi

O-glycosylated.By similarity
Phosphorylated by CDK5 (PubMed:17009320). Phosphorylated by GSK3B (By similarity).By similarity1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO35116.
PRIDEiO35116.

PTM databases

SwissPalmiO35116.

Expressioni

Tissue specificityi

Predominantly expressed in brain; accumulates in cortical neurons (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000010649.

Interactioni

Subunit structurei

Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain (By similarity). Binds to PSEN1 (By similarity). Interacts with ZBTB33 (By similarity). Interacts with ARHGEF28 (By similarity). Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) (By similarity). Interacts with PDZD2 (PubMed:10896674). Interacts with CDK5 (PubMed:17009320). Interacts with CTNBB1 (By similarity). Interacts with GSK3A and GSK3B (By similarity). Interacts with DNM2 (By similarity).By similarity2 Publications

Protein-protein interaction databases

IntActiO35116. 1 interactor.
MINTiMINT-87323.
STRINGi10116.ENSRNOP00000045121.

Structurei

3D structure databases

ProteinModelPortaliO35116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 59ARM 1Add BLAST40
Repeati64 – 104ARM 2Add BLAST41
Repeati120 – 162ARM 3Add BLAST43
Repeati166 – 211ARM 4Add BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi249 – 255Poly-Lys7

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains at least 4 ARM repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
HOGENOMiHOG000231863.
InParanoidiO35116.
PhylomeDBiO35116.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PfamiPF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O35116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FPSVQSNAAA YLQHLCFGDN KIKAEIRRQG GIQLLVDLLD HRMTEVHRSA
60 70 80 90 100
CGALRNLVYG KANDDNKIAL KNCGGIPALV RLLRKTTDLE IRELVTGVLW
110 120 130 140 150
NLSSCDALKM PIIQDALAVL TNAVIIPHSG WENSPLQDDR KIQLHSSQVL
160 170 180 190 200
RNATGCLRNV SSAGEEARRR MRECDGLTDA LLYVIQSALG SSEIDSKTVE
210 220 230 240 250
NCVCILRNLS YRLAAETSQG QHMGTDELDG LLCGEANGKD AESSGCWGKK
260
KKKKKSQDQW DGVG
Length:264
Mass (Da):28,928
Last modified:January 1, 1998 - v1
Checksum:i065A886B8D2F58E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2641

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008752 mRNA. Translation: BAA23384.1.
UniGeneiRn.15163.

Genome annotation databases

UCSCiRGD:620734. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008752 mRNA. Translation: BAA23384.1.
UniGeneiRn.15163.

3D structure databases

ProteinModelPortaliO35116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35116. 1 interactor.
MINTiMINT-87323.
STRINGi10116.ENSRNOP00000045121.

PTM databases

SwissPalmiO35116.

Proteomic databases

PaxDbiO35116.
PRIDEiO35116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620734. rat.

Organism-specific databases

RGDi620734. Ctnnd2.

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
HOGENOMiHOG000231863.
InParanoidiO35116.
PhylomeDBiO35116.

Gene expression databases

BgeeiENSRNOG00000010649.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PfamiPF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTND2_RAT
AccessioniPrimary (citable) accession number: O35116
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.