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O35112

- CD166_RAT

UniProt

O35112 - CD166_RAT

Protein

CD166 antigen

Gene

Alcam

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. May be involved in osteogenesis. May play an important role in the development of a variety of mesenchymal tissues By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. motor neuron axon guidance Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD166 antigen
    Alternative name(s):
    Activated leukocyte cell adhesion molecule
    HB2
    KG-CAM
    Protein MEMD
    SB-10 antigen
    CD_antigen: CD166
    Gene namesi
    Name:Alcam
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 11

    Organism-specific databases

    RGDi619972. Alcam.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. external side of plasma membrane Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 583556CD166 antigenPRO_0000014661Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 113PROSITE-ProRule annotation
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi157 ↔ 220PROSITE-ProRule annotation
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi270 ↔ 313PROSITE-ProRule annotation
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi354 ↔ 392PROSITE-ProRule annotation
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi435 ↔ 485PROSITE-ProRule annotation
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The N-terminus is blocked.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO35112.
    PRIDEiO35112.

    Expressioni

    Tissue specificityi

    Strongest expression in the lung, then brain, liver, and kidney. Present in the somatosensory system, basal ganglia, cortex, olfactory system, and circumventricular organs.

    Gene expression databases

    GenevestigatoriO35112.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000002738.

    Structurei

    3D structure databases

    ProteinModelPortaliO35112.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 527500ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini550 – 58334CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei528 – 54922HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 12093Ig-like V-type 1Add
    BLAST
    Domaini125 – 234110Ig-like V-type 2Add
    BLAST
    Domaini245 – 32884Ig-like C2-type 1Add
    BLAST
    Domaini333 – 40977Ig-like C2-type 2Add
    BLAST
    Domaini416 – 50186Ig-like C2-type 3Add
    BLAST

    Domaini

    The CD6 binding site is located in the N-terminal Ig-like domain.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148902.
    GeneTreeiENSGT00530000063457.
    HOGENOMiHOG000070101.
    HOVERGENiHBG050847.
    InParanoidiO35112.
    KOiK06547.
    OMAiDIYYPTE.
    OrthoDBiEOG74J97B.
    PhylomeDBiO35112.
    TreeFamiTF321859.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35112-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKGSPSCR LVFCLLISAA VLRPGLGWYT VNSAYGDTIV MPCRLDVPQN    50
    LMFGKWKYEK PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL SLSENYTLSI 100
    NNAKISDEKR FVCMLVTEDN VFEAPTLVKV FKQPSKPEIV NRAAFLETEQ 150
    LKKLGDCISR DSYPDGNITW YRNGKVLQPV DGEVSILFKK EIDPGTQLYT 200
    MTSSLEYKTT KSDIQMPFTC SVTYYGPSGQ KTIYSEQAIF DIYYPTEQVT 250
    IQVLPPKNAI KEGDNITLQC LGNGNPPPEE FMFYLPGQAE GIRSSNTYTL 300
    TDVRRNATGD YKCSLIDQRN MAASTTITVH YLDLSLNPSG EVTKQIGDTL 350
    PVSCTISASR NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE 400
    GLKKRESLTL IVEGKPQIKM TKKTDPSGLS KTIICHVEGF PKPAIQWTIT 450
    GSGSVINQTE ESPYINGRYY SKIIISPEEN VTLTCTAENQ LERTVNSLNV 500
    SAISIPEHDE ADDISDENRE KVNDQAKLIV GIVVGLLLAA LVAGVVYWLY 550
    MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA 583
    Length:583
    Mass (Da):65,022
    Last modified:January 1, 1998 - v1
    Checksum:iD36B73854F5DF61E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti339 – 3391S → G in CAA73693. (PubMed:9556065)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008538 mRNA. Translation: BAA23279.1.
    BC061970 mRNA. Translation: AAH61970.1.
    Y13240 mRNA. Translation: CAA73692.1.
    Y13241 mRNA. Translation: CAA73693.1.
    RefSeqiNP_113941.1. NM_031753.1.
    UniGeneiRn.5789.

    Genome annotation databases

    EnsembliENSRNOT00000002738; ENSRNOP00000002738; ENSRNOG00000001989.
    GeneIDi79559.
    KEGGirno:79559.
    UCSCiRGD:619972. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008538 mRNA. Translation: BAA23279.1 .
    BC061970 mRNA. Translation: AAH61970.1 .
    Y13240 mRNA. Translation: CAA73692.1 .
    Y13241 mRNA. Translation: CAA73693.1 .
    RefSeqi NP_113941.1. NM_031753.1.
    UniGenei Rn.5789.

    3D structure databases

    ProteinModelPortali O35112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000002738.

    Proteomic databases

    PaxDbi O35112.
    PRIDEi O35112.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002738 ; ENSRNOP00000002738 ; ENSRNOG00000001989 .
    GeneIDi 79559.
    KEGGi rno:79559.
    UCSCi RGD:619972. rat.

    Organism-specific databases

    CTDi 214.
    RGDi 619972. Alcam.

    Phylogenomic databases

    eggNOGi NOG148902.
    GeneTreei ENSGT00530000063457.
    HOGENOMi HOG000070101.
    HOVERGENi HBG050847.
    InParanoidi O35112.
    KOi K06547.
    OMAi DIYYPTE.
    OrthoDBi EOG74J97B.
    PhylomeDBi O35112.
    TreeFami TF321859.

    Miscellaneous databases

    NextBioi 614842.
    PROi O35112.

    Gene expression databases

    Genevestigatori O35112.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of HB2, a candidate high density lipoprotein receptor. Sequence homology with members of the immunoglobulin superfamily of membrane proteins."
      Matsumoto A., Mitchell A., Kurata H., Pyle L., Kondo K., Itakura H., Fidge N.
      J. Biol. Chem. 272:16778-16782(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    3. "Distribution and characteristics of a 90 kDa protein, KG-CAM, in the rat CNS."
      Peduzzi J.D., Irwin M.H., Geisert E.E. Jr.
      Brain Res. 640:296-307(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-38.
    4. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 45-55; 58-71; 77-87; 111-129; 143-152; 154-160; 176-189; 306-312 AND 406-423, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    5. "Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation."
      Bruder S.P., Ricalton N.S., Boynton R.E., Connolly T.J., Jaiswal N., Zaia J., Barry F.P.
      J. Bone Miner. Res. 13:655-663(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 94-156 AND 270-361.
      Tissue: Mesenchymal cell.

    Entry informationi

    Entry nameiCD166_RAT
    AccessioniPrimary (citable) accession number: O35112
    Secondary accession number(s): O55172
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3