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Protein

Potassium channel subfamily K member 3

Gene

Kcnk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1299316. TWIK-releated acid-sensitive K+ channel (TASK).
R-MMU-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 3
Alternative name(s):
Acid-sensitive potassium channel protein TASK-1
Cardiac two pore background K(+) channel
TWIK-related acid-sensitive K(+) channel 1
Two pore potassium channel KT3.1
Short name:
Two pore K(+) channel KT3.1
cTBAK-1
Gene namesi
Name:Kcnk3
Synonyms:Ctbak, Task, Task1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1100509. Kcnk3.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Intramembranei78 – 10124Pore-forming; Name=Pore-forming 1Sequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Topological domaini129 – 15830CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Intramembranei184 – 20724Pore-forming; Name=Pore-forming 2Sequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Topological domaini244 – 409166CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Potassium channel subfamily K member 3PRO_0000101745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO35111.
PeptideAtlasiO35111.
PRIDEiO35111.

PTM databases

iPTMnetiO35111.
PhosphoSiteiO35111.

Expressioni

Tissue specificityi

Very strong expression in heart, also detected in kidney, brain, skin, testis, lung, skeletal muscle, small intestine and stomach. Not detected in liver, thymus or spleen.

Gene expression databases

BgeeiENSMUSG00000049265.
CleanExiMM_KCNK3.
GenevisibleiO35111. MM.

Interactioni

Subunit structurei

Homodimer. Heterodimer with KCNK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098987.

Structurei

3D structure databases

ProteinModelPortaliO35111.
SMRiO35111. Positions 18-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiO35111.
KOiK04914.
OMAiFRSLMKR.
OrthoDBiEOG091G08DH.
PhylomeDBiO35111.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR005406. KCNK3.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01584. TASK1CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

O35111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPEMIERQR LELRQLELRA
60 70 80 90 100
RYNLSEGGYE ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PSTDGGKVFC MFYALLGIPL TLVMFQSLGE RINTFVRYLL HRAKRGLGMR
160 170 180 190 200
HAEVSMANMV LIGFVSCIST LCIGAAAFSY YERWTFFQAY YYCFITLTTI
210 220 230 240 250
GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN LVVLRFMTMN
260 270 280 290 300
AEDEKRDAEH RALLTHNGQA VGLGGLSCLS GSLGDGVRPR DPVTCAAAAG
310 320 330 340 350
GVGVGVGGSG FRNVYAEVLH FQSMCSCLWY KSREKLQYSI PMIIPRDLST
360 370 380 390 400
SDTCVEHSHS SPGGGGRYSD TPSHPCLCSG TQRSAISSVS TGLHSLAAFR

GLMKRRSSV
Length:409
Mass (Da):45,068
Last modified:August 1, 1998 - v2
Checksum:i35236E011AAC5687
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41Q → E in AAC53367 (PubMed:9312005).Curated
Sequence conflicti123 – 1231V → I in AAC53367 (PubMed:9312005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008537 mRNA. Translation: BAA25436.1.
AF241798, AF242508 Genomic DNA. Translation: AAF81418.1.
AF065162 mRNA. Translation: AAG29339.1.
AF006824 mRNA. Translation: AAC53367.1.
AB013345 mRNA. Translation: BAA28349.1.
CCDSiCCDS19160.1.
RefSeqiNP_034738.1. NM_010608.2.
UniGeneiMm.439936.

Genome annotation databases

EnsembliENSMUST00000066295; ENSMUSP00000098987; ENSMUSG00000049265.
GeneIDi16527.
KEGGimmu:16527.
UCSCiuc008wvr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008537 mRNA. Translation: BAA25436.1.
AF241798, AF242508 Genomic DNA. Translation: AAF81418.1.
AF065162 mRNA. Translation: AAG29339.1.
AF006824 mRNA. Translation: AAC53367.1.
AB013345 mRNA. Translation: BAA28349.1.
CCDSiCCDS19160.1.
RefSeqiNP_034738.1. NM_010608.2.
UniGeneiMm.439936.

3D structure databases

ProteinModelPortaliO35111.
SMRiO35111. Positions 18-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098987.

PTM databases

iPTMnetiO35111.
PhosphoSiteiO35111.

Proteomic databases

PaxDbiO35111.
PeptideAtlasiO35111.
PRIDEiO35111.

Protocols and materials databases

DNASUi16527.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066295; ENSMUSP00000098987; ENSMUSG00000049265.
GeneIDi16527.
KEGGimmu:16527.
UCSCiuc008wvr.1. mouse.

Organism-specific databases

CTDi3777.
MGIiMGI:1100509. Kcnk3.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiO35111.
KOiK04914.
OMAiFRSLMKR.
OrthoDBiEOG091G08DH.
PhylomeDBiO35111.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiR-MMU-1299316. TWIK-releated acid-sensitive K+ channel (TASK).
R-MMU-5576886. Phase 4 - resting membrane potential.

Miscellaneous databases

PROiO35111.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049265.
CleanExiMM_KCNK3.
GenevisibleiO35111. MM.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR005406. KCNK3.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01584. TASK1CHANNEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNK3_MOUSE
AccessioniPrimary (citable) accession number: O35111
Secondary accession number(s): O35163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Inactivated by barium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.