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O35103

- OMD_MOUSE

UniProt

O35103 - OMD_MOUSE

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Protein
Osteomodulin
Gene
Omd
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name:
KSPG osteomodulin
Osteoadherin
Short name:
OSAD
Gene namesi
Name:Omd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1350918. Omd.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 423403Osteomodulin
PRO_0000032755Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Sulfotyrosine By similarity
Modified residuei25 – 251Sulfotyrosine By similarity
Modified residuei31 – 311Sulfotyrosine By similarity
Modified residuei39 – 391Sulfotyrosine By similarity
Modified residuei51 – 511Sulfotyrosine By similarity
Modified residuei77 – 771Sulfotyrosine By similarity
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi321 ↔ 353 By similarity
Modified residuei413 – 4131Sulfotyrosine By similarity
Modified residuei414 – 4141Sulfotyrosine By similarity

Post-translational modificationi

Binds keratan sulfate chains By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

Proteomic databases

PRIDEiO35103.

Expressioni

Tissue specificityi

Bone specific.

Gene expression databases

BgeeiO35103.
CleanExiMM_OMD.
GenevestigatoriO35103.

Interactioni

Subunit structurei

Binds the alpha(V)beta(3)-integrin By similarity.

Structurei

3D structure databases

ProteinModelPortaliO35103.
SMRiO35103. Positions 61-352.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 9139LRRNT
Add
BLAST
Repeati92 – 11322LRR 1
Add
BLAST
Repeati116 – 12914LRR 2
Add
BLAST
Repeati142 – 16423LRR 3
Add
BLAST
Repeati165 – 18420LRR 4
Add
BLAST
Repeati187 – 20721LRR 5
Add
BLAST
Repeati213 – 23321LRR 6
Add
BLAST
Repeati234 – 25522LRR 7
Add
BLAST
Repeati258 – 27922LRR 8
Add
BLAST
Repeati281 – 29414LRR 9
Add
BLAST
Repeati301 – 32222LRR 10
Add
BLAST
Repeati331 – 35323LRR 11
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 7817Cys-rich
Add
BLAST
Compositional biasi385 – 40723Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00600000084286.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiO35103.
KOiK08124.
OMAiFYIPRNL.
OrthoDBiEOG741Z2B.
PhylomeDBiO35103.
TreeFamiTF334562.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35103-1 [UniParc]FASTAAdd to Basket

« Hide

MGFLSPIYVL FFCFGVRVYC QYEAYRWDDD YDQEPNEDYD PEFQFHQNIE    50
YGVPFYNNIL GCAKECFCPT NFPTSMYCDN RKLKTIPIIP MHIQQLNLQF 100
NDIEAVTANS FINATHLKEI NLSHNKIKSQ KIDYGVFAKL SNLQQLHLEH 150
NNLEEFPFPL PKSLERLLLG YNEISILPTN AMDGLVNVTM LDLCYNHLSD 200
SMLKEKTLSK MEKLMQLNLC NNRLESMPLG LPSSLMYLSL ENNSISSIPD 250
NYFDKLPKLH ALRISHNKLE DIPYDIFNLS NLIELNVGHN KLKQAFYIPR 300
NLEHLYLQNN EIESINVTMI CPSPDPVHHH HLTYLRVDQN KLKEPISSYI 350
FFCFPRIHSI YYGEQRSTNG ETIQLKTQVF RSYQEEEEED DHDSQDNTLE 400
GQEVSDEHYN SHYYEMQEWQ DTI 423
Length:423
Mass (Da):49,745
Last modified:January 1, 1998 - v1
Checksum:i41ED7CA6B3A6F3B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007848 mRNA. Translation: BAA22790.1.
CCDSiCCDS26504.1.
RefSeqiNP_036180.1. NM_012050.2.
XP_006516991.1. XM_006516928.1.
UniGeneiMm.390589.

Genome annotation databases

EnsembliENSMUST00000065494; ENSMUSP00000065706; ENSMUSG00000048368.
GeneIDi27047.
KEGGimmu:27047.
UCSCiuc007qjp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007848 mRNA. Translation: BAA22790.1 .
CCDSi CCDS26504.1.
RefSeqi NP_036180.1. NM_012050.2.
XP_006516991.1. XM_006516928.1.
UniGenei Mm.390589.

3D structure databases

ProteinModelPortali O35103.
SMRi O35103. Positions 61-352.
ModBasei Search...

Proteomic databases

PRIDEi O35103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065494 ; ENSMUSP00000065706 ; ENSMUSG00000048368 .
GeneIDi 27047.
KEGGi mmu:27047.
UCSCi uc007qjp.1. mouse.

Organism-specific databases

CTDi 4958.
MGIi MGI:1350918. Omd.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00600000084286.
HOGENOMi HOG000234447.
HOVERGENi HBG108061.
InParanoidi O35103.
KOi K08124.
OMAi FYIPRNL.
OrthoDBi EOG741Z2B.
PhylomeDBi O35103.
TreeFami TF334562.

Enzyme and pathway databases

Reactomei REACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.

Miscellaneous databases

NextBioi 304973.
PROi O35103.
SOURCEi Search...

Gene expression databases

Bgeei O35103.
CleanExi MM_OMD.
Genevestigatori O35103.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cloning and characterization of a cDNA for the novel bone matrix protein; osteomodulin."
    Ohno I., Matsubara K., Okubo K.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiOMD_MOUSE
AccessioniPrimary (citable) accession number: O35103
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi