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Protein

Osteomodulin

Gene

Omd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.
REACT_268667. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
REACT_269577. Defective CHST6 causes MCDC1.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name:
KSPG osteomodulin
Osteoadherin
Short name:
OSAD
Gene namesi
Name:Omd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1350918. Omd.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 423403OsteomodulinPRO_0000032755Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221SulfotyrosineBy similarity
Modified residuei25 – 251SulfotyrosineBy similarity
Modified residuei31 – 311SulfotyrosineBy similarity
Modified residuei39 – 391SulfotyrosineBy similarity
Modified residuei51 – 511SulfotyrosineBy similarity
Modified residuei77 – 771SulfotyrosineBy similarity
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi321 ↔ 353By similarity
Modified residuei413 – 4131SulfotyrosineBy similarity
Modified residuei414 – 4141SulfotyrosineBy similarity

Post-translational modificationi

Binds keratan sulfate chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

Proteomic databases

PRIDEiO35103.

Expressioni

Tissue specificityi

Bone specific.

Gene expression databases

BgeeiO35103.
CleanExiMM_OMD.
ExpressionAtlasiO35103. baseline and differential.
GenevestigatoriO35103.

Interactioni

Subunit structurei

Binds the alpha(V)beta(3)-integrin.By similarity

Structurei

3D structure databases

ProteinModelPortaliO35103.
SMRiO35103. Positions 61-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 9139LRRNTAdd
BLAST
Repeati92 – 11322LRR 1Add
BLAST
Repeati116 – 12914LRR 2Add
BLAST
Repeati142 – 16423LRR 3Add
BLAST
Repeati165 – 18420LRR 4Add
BLAST
Repeati187 – 20721LRR 5Add
BLAST
Repeati213 – 23321LRR 6Add
BLAST
Repeati234 – 25522LRR 7Add
BLAST
Repeati258 – 27922LRR 8Add
BLAST
Repeati281 – 29414LRR 9Add
BLAST
Repeati301 – 32222LRR 10Add
BLAST
Repeati331 – 35323LRR 11Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 7817Cys-richAdd
BLAST
Compositional biasi385 – 40723Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiO35103.
KOiK08124.
OMAiLMYLSLE.
OrthoDBiEOG741Z2B.
PhylomeDBiO35103.
TreeFamiTF334562.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLSPIYVL FFCFGVRVYC QYEAYRWDDD YDQEPNEDYD PEFQFHQNIE
60 70 80 90 100
YGVPFYNNIL GCAKECFCPT NFPTSMYCDN RKLKTIPIIP MHIQQLNLQF
110 120 130 140 150
NDIEAVTANS FINATHLKEI NLSHNKIKSQ KIDYGVFAKL SNLQQLHLEH
160 170 180 190 200
NNLEEFPFPL PKSLERLLLG YNEISILPTN AMDGLVNVTM LDLCYNHLSD
210 220 230 240 250
SMLKEKTLSK MEKLMQLNLC NNRLESMPLG LPSSLMYLSL ENNSISSIPD
260 270 280 290 300
NYFDKLPKLH ALRISHNKLE DIPYDIFNLS NLIELNVGHN KLKQAFYIPR
310 320 330 340 350
NLEHLYLQNN EIESINVTMI CPSPDPVHHH HLTYLRVDQN KLKEPISSYI
360 370 380 390 400
FFCFPRIHSI YYGEQRSTNG ETIQLKTQVF RSYQEEEEED DHDSQDNTLE
410 420
GQEVSDEHYN SHYYEMQEWQ DTI
Length:423
Mass (Da):49,745
Last modified:January 1, 1998 - v1
Checksum:i41ED7CA6B3A6F3B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007848 mRNA. Translation: BAA22790.1.
CCDSiCCDS26504.1.
RefSeqiNP_036180.1. NM_012050.2.
XP_006516991.1. XM_006516928.1.
UniGeneiMm.390589.

Genome annotation databases

EnsembliENSMUST00000065494; ENSMUSP00000065706; ENSMUSG00000048368.
GeneIDi27047.
KEGGimmu:27047.
UCSCiuc007qjp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007848 mRNA. Translation: BAA22790.1.
CCDSiCCDS26504.1.
RefSeqiNP_036180.1. NM_012050.2.
XP_006516991.1. XM_006516928.1.
UniGeneiMm.390589.

3D structure databases

ProteinModelPortaliO35103.
SMRiO35103. Positions 61-357.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO35103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065494; ENSMUSP00000065706; ENSMUSG00000048368.
GeneIDi27047.
KEGGimmu:27047.
UCSCiuc007qjp.1. mouse.

Organism-specific databases

CTDi4958.
MGIiMGI:1350918. Omd.

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiO35103.
KOiK08124.
OMAiLMYLSLE.
OrthoDBiEOG741Z2B.
PhylomeDBiO35103.
TreeFamiTF334562.

Enzyme and pathway databases

ReactomeiREACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.
REACT_268667. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
REACT_269577. Defective CHST6 causes MCDC1.

Miscellaneous databases

NextBioi304973.
PROiO35103.
SOURCEiSearch...

Gene expression databases

BgeeiO35103.
CleanExiMM_OMD.
ExpressionAtlasiO35103. baseline and differential.
GenevestigatoriO35103.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The cloning and characterization of a cDNA for the novel bone matrix protein; osteomodulin."
    Ohno I., Matsubara K., Okubo K.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiOMD_MOUSE
AccessioniPrimary (citable) accession number: O35103
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.