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O35103

- OMD_MOUSE

UniProt

O35103 - OMD_MOUSE

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Protein

Osteomodulin

Gene

Omd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.
REACT_268667. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
REACT_269577. Defective CHST6 causes MCDC1.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name:
KSPG osteomodulin
Osteoadherin
Short name:
OSAD
Gene namesi
Name:Omd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1350918. Omd.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 423403OsteomodulinPRO_0000032755Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221SulfotyrosineBy similarity
Modified residuei25 – 251SulfotyrosineBy similarity
Modified residuei31 – 311SulfotyrosineBy similarity
Modified residuei39 – 391SulfotyrosineBy similarity
Modified residuei51 – 511SulfotyrosineBy similarity
Modified residuei77 – 771SulfotyrosineBy similarity
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi321 ↔ 353By similarity
Modified residuei413 – 4131SulfotyrosineBy similarity
Modified residuei414 – 4141SulfotyrosineBy similarity

Post-translational modificationi

Binds keratan sulfate chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

Proteomic databases

PRIDEiO35103.

Expressioni

Tissue specificityi

Bone specific.

Gene expression databases

BgeeiO35103.
CleanExiMM_OMD.
ExpressionAtlasiO35103. baseline and differential.
GenevestigatoriO35103.

Interactioni

Subunit structurei

Binds the alpha(V)beta(3)-integrin.By similarity

Structurei

3D structure databases

ProteinModelPortaliO35103.
SMRiO35103. Positions 61-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 9139LRRNTAdd
BLAST
Repeati92 – 11322LRR 1Add
BLAST
Repeati116 – 12914LRR 2Add
BLAST
Repeati142 – 16423LRR 3Add
BLAST
Repeati165 – 18420LRR 4Add
BLAST
Repeati187 – 20721LRR 5Add
BLAST
Repeati213 – 23321LRR 6Add
BLAST
Repeati234 – 25522LRR 7Add
BLAST
Repeati258 – 27922LRR 8Add
BLAST
Repeati281 – 29414LRR 9Add
BLAST
Repeati301 – 32222LRR 10Add
BLAST
Repeati331 – 35323LRR 11Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 7817Cys-richAdd
BLAST
Compositional biasi385 – 40723Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiO35103.
KOiK08124.
OMAiFYIPRNL.
OrthoDBiEOG741Z2B.
PhylomeDBiO35103.
TreeFamiTF334562.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35103-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFLSPIYVL FFCFGVRVYC QYEAYRWDDD YDQEPNEDYD PEFQFHQNIE
60 70 80 90 100
YGVPFYNNIL GCAKECFCPT NFPTSMYCDN RKLKTIPIIP MHIQQLNLQF
110 120 130 140 150
NDIEAVTANS FINATHLKEI NLSHNKIKSQ KIDYGVFAKL SNLQQLHLEH
160 170 180 190 200
NNLEEFPFPL PKSLERLLLG YNEISILPTN AMDGLVNVTM LDLCYNHLSD
210 220 230 240 250
SMLKEKTLSK MEKLMQLNLC NNRLESMPLG LPSSLMYLSL ENNSISSIPD
260 270 280 290 300
NYFDKLPKLH ALRISHNKLE DIPYDIFNLS NLIELNVGHN KLKQAFYIPR
310 320 330 340 350
NLEHLYLQNN EIESINVTMI CPSPDPVHHH HLTYLRVDQN KLKEPISSYI
360 370 380 390 400
FFCFPRIHSI YYGEQRSTNG ETIQLKTQVF RSYQEEEEED DHDSQDNTLE
410 420
GQEVSDEHYN SHYYEMQEWQ DTI
Length:423
Mass (Da):49,745
Last modified:January 1, 1998 - v1
Checksum:i41ED7CA6B3A6F3B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007848 mRNA. Translation: BAA22790.1.
CCDSiCCDS26504.1.
RefSeqiNP_036180.1. NM_012050.2.
XP_006516991.1. XM_006516928.1.
UniGeneiMm.390589.

Genome annotation databases

EnsembliENSMUST00000065494; ENSMUSP00000065706; ENSMUSG00000048368.
GeneIDi27047.
KEGGimmu:27047.
UCSCiuc007qjp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007848 mRNA. Translation: BAA22790.1 .
CCDSi CCDS26504.1.
RefSeqi NP_036180.1. NM_012050.2.
XP_006516991.1. XM_006516928.1.
UniGenei Mm.390589.

3D structure databases

ProteinModelPortali O35103.
SMRi O35103. Positions 61-352.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O35103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065494 ; ENSMUSP00000065706 ; ENSMUSG00000048368 .
GeneIDi 27047.
KEGGi mmu:27047.
UCSCi uc007qjp.1. mouse.

Organism-specific databases

CTDi 4958.
MGIi MGI:1350918. Omd.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118969.
HOGENOMi HOG000234447.
HOVERGENi HBG108061.
InParanoidi O35103.
KOi K08124.
OMAi FYIPRNL.
OrthoDBi EOG741Z2B.
PhylomeDBi O35103.
TreeFami TF334562.

Enzyme and pathway databases

Reactomei REACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.
REACT_268667. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
REACT_269577. Defective CHST6 causes MCDC1.

Miscellaneous databases

NextBioi 304973.
PROi O35103.
SOURCEi Search...

Gene expression databases

Bgeei O35103.
CleanExi MM_OMD.
ExpressionAtlasi O35103. baseline and differential.
Genevestigatori O35103.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cloning and characterization of a cDNA for the novel bone matrix protein; osteomodulin."
    Ohno I., Matsubara K., Okubo K.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiOMD_MOUSE
AccessioniPrimary (citable) accession number: O35103
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3