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O35103 (OMD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name=KSPG osteomodulin
Osteoadherin
Short name=OSAD
Gene names
Name:Omd
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin By similarity.

Subunit structure

Binds the alpha(V)beta(3)-integrin By similarity.

Subcellular location

Secreted › extracellular space › extracellular matrix By similarity.

Tissue specificity

Bone specific.

Post-translational modification

Binds keratan sulfate chains By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Contains 11 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentExtracellular matrix
Secreted
   DomainLeucine-rich repeat
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
Proteoglycan
Sulfation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 423403Osteomodulin
PRO_0000032755

Regions

Domain53 – 9139LRRNT
Repeat92 – 11322LRR 1
Repeat116 – 12914LRR 2
Repeat142 – 16423LRR 3
Repeat165 – 18420LRR 4
Repeat187 – 20721LRR 5
Repeat213 – 23321LRR 6
Repeat234 – 25522LRR 7
Repeat258 – 27922LRR 8
Repeat281 – 29414LRR 9
Repeat301 – 32222LRR 10
Repeat331 – 35323LRR 11
Compositional bias62 – 7817Cys-rich
Compositional bias385 – 40723Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue221Sulfotyrosine By similarity
Modified residue251Sulfotyrosine By similarity
Modified residue311Sulfotyrosine By similarity
Modified residue391Sulfotyrosine By similarity
Modified residue511Sulfotyrosine By similarity
Modified residue771Sulfotyrosine By similarity
Modified residue4131Sulfotyrosine By similarity
Modified residue4141Sulfotyrosine By similarity
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential
Disulfide bond321 ↔ 353 By similarity

Sequences

Sequence LengthMass (Da)Tools
O35103 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 41ED7CA6B3A6F3B7

FASTA42349,745
        10         20         30         40         50         60 
MGFLSPIYVL FFCFGVRVYC QYEAYRWDDD YDQEPNEDYD PEFQFHQNIE YGVPFYNNIL 

        70         80         90        100        110        120 
GCAKECFCPT NFPTSMYCDN RKLKTIPIIP MHIQQLNLQF NDIEAVTANS FINATHLKEI 

       130        140        150        160        170        180 
NLSHNKIKSQ KIDYGVFAKL SNLQQLHLEH NNLEEFPFPL PKSLERLLLG YNEISILPTN 

       190        200        210        220        230        240 
AMDGLVNVTM LDLCYNHLSD SMLKEKTLSK MEKLMQLNLC NNRLESMPLG LPSSLMYLSL 

       250        260        270        280        290        300 
ENNSISSIPD NYFDKLPKLH ALRISHNKLE DIPYDIFNLS NLIELNVGHN KLKQAFYIPR 

       310        320        330        340        350        360 
NLEHLYLQNN EIESINVTMI CPSPDPVHHH HLTYLRVDQN KLKEPISSYI FFCFPRIHSI 

       370        380        390        400        410        420 
YYGEQRSTNG ETIQLKTQVF RSYQEEEEED DHDSQDNTLE GQEVSDEHYN SHYYEMQEWQ 


DTI

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References

[1]"The cloning and characterization of a cDNA for the novel bone matrix protein; osteomodulin."
Ohno I., Matsubara K., Okubo K.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB007848 mRNA. Translation: BAA22790.1.
IPIIPI00127402.
RefSeqNP_036180.1. NM_012050.2.
UniGeneMm.390589.

3D structure databases

ProteinModelPortalO35103.
SMRO35103. Positions 61-348.
ModBaseSearch...

Proteomic databases

PRIDEO35103.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000065494; ENSMUSP00000065706; ENSMUSG00000048368.
GeneID27047.
KEGGmmu:27047.
UCSCuc007qjp.1. mouse.

Organism-specific databases

CTD4958.
MGIMGI:1350918. Omd.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00600000084286.
HOGENOMHOG000234447.
HOVERGENHBG108061.
InParanoidO35103.
KOK08124.
OMAFYIPRNL.
OrthoDBEOG415GDJ.

Gene expression databases

ArrayExpressO35103.
BgeeO35103.
CleanExMM_OMD.
GenevestigatorO35103.
GermOnlineENSMUSG00000048368. Mus musculus.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF00560. LRR_1. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio304973.
SOURCESearch...

Entry information

Entry nameOMD_MOUSE
AccessionPrimary (citable) accession number: O35103
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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