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Protein

Neurochondrin

Gene

Ncdn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.1 Publication

GO - Biological processi

  • bone resorption Source: Ensembl
  • neuron projection development Source: UniProtKB
  • regulation of neuronal synaptic plasticity Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neurochondrin
Alternative name(s):
Neurite outgrowth-related protein from the rat brain
Norbin
Gene namesi
Name:Ncdn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621734. Ncdn.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • dendrite Source: UniProtKB
  • membrane Source: Ensembl
  • neuronal cell body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 729728NeurochondrinPRO_0000324619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei448 – 4481PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO35095.
PRIDEiO35095.

PTM databases

iPTMnetiO35095.
PhosphoSiteiO35095.
SwissPalmiO35095.

Expressioni

Tissue specificityi

Expressed in brain and in peripheral nervous system (at protein level). Weakly expressed in neurites.3 Publications

Inductioni

Upon tetraethylammonium (TEA) treatment.1 Publication

Gene expression databases

GenevisibleiO35095. RN.

Interactioni

Subunit structurei

Interacts with MCHR1 and SEMA4C (By similarity). Interacts with DIAPH1 (via FH3 domain) (By similarity). Interacts with GRM5.By similarity1 Publication

Protein-protein interaction databases

BioGridi250125. 1 interaction.
IntActiO35095. 1 interaction.
STRINGi10116.ENSRNOP00000016229.

Family & Domainsi

Sequence similaritiesi

Belongs to the neurochondrin family.Curated

Phylogenomic databases

eggNOGiKOG2611. Eukaryota.
ENOG410XRYT. LUCA.
GeneTreeiENSGT00390000013601.
HOGENOMiHOG000113742.
HOVERGENiHBG097452.
InParanoidiO35095.
OMAiATIRFLW.
OrthoDBiEOG72ZCDD.
PhylomeDBiO35095.
TreeFamiTF323752.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR008709. Neurochondrin.
[Graphical view]
PANTHERiPTHR13109. PTHR13109. 1 hit.
PfamiPF05536. Neurochondrin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCCDLAAAG QLGKAGIMAS DCEPALNQAE SRNPTLERYL GALREAKNDS
60 70 80 90 100
EQFAALLLVT KAVKAGDIDA KTRRRIFDAV GFTFPNRLLT TKEAPDGCPD
110 120 130 140 150
HVLRALGVAL LACFCSDPEL ASHPQVLNKI PILCTFLTAR GDPDDAARRS
160 170 180 190 200
MIDDTYQCLT AVAGTPRGPR HLIAGGTVSA LCQAYLGHGY GFDQALALLV
210 220 230 240 250
GLLAAAETQC WKEAEPDLLA VLRGLSEDFQ RAEDASKFEL CQLLPLFLPP
260 270 280 290 300
TTVPPECHRD LQAGLARILG SKLSSWQRNP ALKLAARLAH ACGSDWIPVG
310 320 330 340 350
SSGSKFLALL VNLACVEVRL ALEETGTEVK EDVVTACYAL MELGIQECTR
360 370 380 390 400
CEQSLLKEPQ KVQLVSIMKE AIGAVIHYLL RVGPEKQKEP FVFASVRILG
410 420 430 440 450
AWLAEETSSL RKEVCQLLPF LVRYAKTLYE EAEEASDISQ QVANLAISPT
460 470 480 490 500
TPGPAWPGDA LRLLLPGWCH LTVEDGPREI LIKEGAPSLL CKYFLQQWEL
510 520 530 540 550
TSPGHDTSVL PDSVEIGLQT CCHIFLNLVV TAPGLIKRDA CFTSLMNTLM
560 570 580 590 600
TSLPSLVQQQ GRLLLAANVA TLGLLMARLL STSPALQGTP ASRGFFAAAI
610 620 630 640 650
LFLSQSHVAR ATPGSDQAVL ALSPDYEGIW ADLQELWFLG MQAFTGCVPL
660 670 680 690 700
LPWLAPAALR SRWPQELLQL LGSVSPNSVK PEMVAAYQGV LVELARANRL
710 720
CREAMRLQAG EETASHYRMA ALEQCLSEP
Length:729
Mass (Da):78,923
Last modified:March 18, 2008 - v2
Checksum:iEDED4B921A6B85CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti381 – 3811R → Q in BAA22938 (PubMed:9398642).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006461 mRNA. Translation: BAA22938.1.
BC087000 mRNA. Translation: AAH87000.1.
PIRiJC5812.
RefSeqiNP_445995.2. NM_053543.2.
UniGeneiRn.5653.

Genome annotation databases

EnsembliENSRNOT00000016230; ENSRNOP00000016229; ENSRNOG00000011751.
GeneIDi89791.
KEGGirno:89791.
UCSCiRGD:621734. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006461 mRNA. Translation: BAA22938.1.
BC087000 mRNA. Translation: AAH87000.1.
PIRiJC5812.
RefSeqiNP_445995.2. NM_053543.2.
UniGeneiRn.5653.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250125. 1 interaction.
IntActiO35095. 1 interaction.
STRINGi10116.ENSRNOP00000016229.

PTM databases

iPTMnetiO35095.
PhosphoSiteiO35095.
SwissPalmiO35095.

Proteomic databases

PaxDbiO35095.
PRIDEiO35095.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016230; ENSRNOP00000016229; ENSRNOG00000011751.
GeneIDi89791.
KEGGirno:89791.
UCSCiRGD:621734. rat.

Organism-specific databases

CTDi23154.
RGDi621734. Ncdn.

Phylogenomic databases

eggNOGiKOG2611. Eukaryota.
ENOG410XRYT. LUCA.
GeneTreeiENSGT00390000013601.
HOGENOMiHOG000113742.
HOVERGENiHBG097452.
InParanoidiO35095.
OMAiATIRFLW.
OrthoDBiEOG72ZCDD.
PhylomeDBiO35095.
TreeFamiTF323752.

Miscellaneous databases

NextBioi617634.
PROiO35095.

Gene expression databases

GenevisibleiO35095. RN.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR008709. Neurochondrin.
[Graphical view]
PANTHERiPTHR13109. PTHR13109. 1 hit.
PfamiPF05536. Neurochondrin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel brain gene, norbin, induced by treatment of tetraethylammonium in rat hippocampal slice and accompanied with neurite-outgrowth in neuro 2a cells."
    Shinozaki K., Maruyama K., Kume H., Kuzume H., Obata K.
    Biochem. Biophys. Res. Commun. 240:766-771(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    Strain: Wistar.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Norbin, a neurite-outgrowth-related protein, is a cytosolic protein localized in the somatodendritic region of neurons and distributed prominently in dendritic outgrowth in Purkinje cells."
    Shinozaki K., Kume H., Kuzume H., Obata K., Maruyama K.
    Brain Res. Mol. Brain Res. 71:364-368(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Identification of Neurochondrin as a new interaction partner of the FH3 domain of the Diaphanous-related formin Dia1."
    Schwaibold E.M., Brandt D.T.
    Biochem. Biophys. Res. Commun. 373:366-372(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling."
    Wang H., Westin L., Nong Y., Birnbaum S., Bendor J., Brismar H., Nestler E., Aperia A., Flajolet M., Greengard P.
    Science 326:1554-1557(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRM5.
  6. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNCDN_RAT
AccessioniPrimary (citable) accession number: O35095
Secondary accession number(s): Q5PQW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: February 17, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.