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Protein

Mitochondrial import inner membrane translocase subunit Tim23

Gene

Timm23

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim23
Gene namesi
Name:Timm23
Synonyms:Tim23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3863. Timm23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 19717HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: RGD
  3. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Mitochondrial import inner membrane translocase subunit Tim23PRO_0000210304Add
BLAST

Proteomic databases

PaxDbiO35093.
PRIDEiO35093.

Expressioni

Gene expression databases

GenevestigatoriO35093.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026932.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000166435.
HOVERGENiHBG057526.
InParanoidiO35093.
KOiK17794.
PhylomeDBiO35093.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

Sequencei

Sequence statusi: Complete.

O35093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGGGSSNK STGGLAGFFG AGGAGYSNAD LAGVPLTGMN PLSPYLNVDP
60 70 80 90 100
RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GALNGLRLGL
110 120 130 140 150
KETQSMPWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG
160 170 180 190 200
AEDDFNTVAA GTMTGMLYKC TGGLRGIARG GLAGLTLTSV YALYNNWEHM

KGSLLQQSL
Length:209
Mass (Da):21,907
Last modified:January 1, 1998 - v1
Checksum:i54D3A8749F6EF21F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006451 mRNA. Translation: BAA21819.1.
PIRiJE0154.
RefSeqiNP_062225.1. NM_019352.2.
UniGeneiRn.154974.
Rn.2230.

Genome annotation databases

GeneIDi54312.
KEGGirno:54312.
UCSCiRGD:3863. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006451 mRNA. Translation: BAA21819.1.
PIRiJE0154.
RefSeqiNP_062225.1. NM_019352.2.
UniGeneiRn.154974.
Rn.2230.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026932.

Proteomic databases

PaxDbiO35093.
PRIDEiO35093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54312.
KEGGirno:54312.
UCSCiRGD:3863. rat.

Organism-specific databases

CTDi100287932.
RGDi3863. Timm23.

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000166435.
HOVERGENiHBG057526.
InParanoidiO35093.
KOiK17794.
PhylomeDBiO35093.

Miscellaneous databases

NextBioi610982.
PROiO35093.

Gene expression databases

GenevestigatoriO35093.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44."
    Ishihara N., Mihara K.
    J. Biochem. 123:722-732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTIM23_RAT
AccessioniPrimary (citable) accession number: O35093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.