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O35093

- TIM23_RAT

UniProt

O35093 - TIM23_RAT

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Protein
Mitochondrial import inner membrane translocase subunit Tim23
Gene
Timm23, Tim23
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
  2. protein binding Source: RGD

GO - Biological processi

  1. intracellular protein transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim23
Gene namesi
Name:Timm23
Synonyms:Tim23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3863. Timm23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Transmembranei125 – 14521Helical; Reviewed prediction
Add
BLAST
Transmembranei181 – 19717Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: RGD
  3. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Mitochondrial import inner membrane translocase subunit Tim23
PRO_0000210304Add
BLAST

Proteomic databases

PaxDbiO35093.
PRIDEiO35093.

Expressioni

Gene expression databases

GenevestigatoriO35093.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026932.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000166435.
HOVERGENiHBG057526.
InParanoidiO35093.
KOiK17794.
PhylomeDBiO35093.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

Sequencei

Sequence statusi: Complete.

O35093-1 [UniParc]FASTAAdd to Basket

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MEGGGGSSNK STGGLAGFFG AGGAGYSNAD LAGVPLTGMN PLSPYLNVDP    50
RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GALNGLRLGL 100
KETQSMPWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG 150
AEDDFNTVAA GTMTGMLYKC TGGLRGIARG GLAGLTLTSV YALYNNWEHM 200
KGSLLQQSL 209
Length:209
Mass (Da):21,907
Last modified:January 1, 1998 - v1
Checksum:i54D3A8749F6EF21F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006451 mRNA. Translation: BAA21819.1.
PIRiJE0154.
RefSeqiNP_062225.1. NM_019352.2.
UniGeneiRn.154974.
Rn.2230.

Genome annotation databases

GeneIDi54312.
KEGGirno:54312.
UCSCiRGD:3863. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006451 mRNA. Translation: BAA21819.1 .
PIRi JE0154.
RefSeqi NP_062225.1. NM_019352.2.
UniGenei Rn.154974.
Rn.2230.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026932.

Proteomic databases

PaxDbi O35093.
PRIDEi O35093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 54312.
KEGGi rno:54312.
UCSCi RGD:3863. rat.

Organism-specific databases

CTDi 100287932.
RGDi 3863. Timm23.

Phylogenomic databases

eggNOGi COG5596.
HOGENOMi HOG000166435.
HOVERGENi HBG057526.
InParanoidi O35093.
KOi K17794.
PhylomeDBi O35093.

Miscellaneous databases

NextBioi 610982.

Gene expression databases

Genevestigatori O35093.

Family and domain databases

InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view ]
Pfami PF02466. Tim17. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00983. 3a0801s02tim23. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44."
    Ishihara N., Mihara K.
    J. Biochem. 123:722-732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTIM23_RAT
AccessioniPrimary (citable) accession number: O35093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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