Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O35093 (TIM23_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import inner membrane translocase subunit Tim23
Gene names
Name:Timm23
Synonyms:Tim23
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Subunit structure

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the Tim17/Tim22/Tim23 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Mitochondrial import inner membrane translocase subunit Tim23
PRO_0000210304

Regions

Transmembrane73 – 9321Helical; Potential
Transmembrane125 – 14521Helical; Potential
Transmembrane181 – 19717Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O35093 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 54D3A8749F6EF21F

FASTA20921,907
        10         20         30         40         50         60 
MEGGGGSSNK STGGLAGFFG AGGAGYSNAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF 

        70         80         90        100        110        120 
ILPTGANKTR GRFELAFFTI GGCCMTGAAF GALNGLRLGL KETQSMPWSK PRNVQILNMV 

       130        140        150        160        170        180 
TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDFNTVAA GTMTGMLYKC TGGLRGIARG 

       190        200 
GLAGLTLTSV YALYNNWEHM KGSLLQQSL 

« Hide

References

[1]"Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44."
Ishihara N., Mihara K.
J. Biochem. 123:722-732(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006451 mRNA. Translation: BAA21819.1.
PIRJE0154.
RefSeqNP_062225.1. NM_019352.2.
UniGeneRn.154974.
Rn.2230.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000026932.

Proteomic databases

PaxDbO35093.
PRIDEO35093.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID54312.
KEGGrno:54312.
UCSCRGD:3863. rat.

Organism-specific databases

CTD100287932.
RGD3863. Timm23.

Phylogenomic databases

eggNOGCOG5596.
HOGENOMHOG000166435.
HOVERGENHBG057526.
InParanoidO35093.
KOK17794.
PhylomeDBO35093.

Gene expression databases

GenevestigatorO35093.

Family and domain databases

InterProIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsTIGR00983. 3a0801s02tim23. 1 hit.
ProtoNetSearch...

Other

NextBio610982.

Entry information

Entry nameTIM23_RAT
AccessionPrimary (citable) accession number: O35093
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families