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O35093

- TIM23_RAT

UniProt

O35093 - TIM23_RAT

Protein

Mitochondrial import inner membrane translocase subunit Tim23

Gene

Timm23

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

    GO - Molecular functioni

    1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
    2. protein binding Source: RGD

    GO - Biological processi

    1. intracellular protein transport Source: RGD

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim23
    Gene namesi
    Name:Timm23
    Synonyms:Tim23
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3863. Timm23.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: RGD
    3. mitochondrial inner membrane presequence translocase complex Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Mitochondrial import inner membrane translocase subunit Tim23PRO_0000210304Add
    BLAST

    Proteomic databases

    PaxDbiO35093.
    PRIDEiO35093.

    Expressioni

    Gene expression databases

    GenevestigatoriO35093.

    Interactioni

    Subunit structurei

    Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026932.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 19717HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tim17/Tim22/Tim23 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5596.
    HOGENOMiHOG000166435.
    HOVERGENiHBG057526.
    InParanoidiO35093.
    KOiK17794.
    PhylomeDBiO35093.

    Family and domain databases

    InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
    IPR005681. Tim23.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O35093-1 [UniParc]FASTAAdd to Basket

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    MEGGGGSSNK STGGLAGFFG AGGAGYSNAD LAGVPLTGMN PLSPYLNVDP    50
    RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GALNGLRLGL 100
    KETQSMPWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG 150
    AEDDFNTVAA GTMTGMLYKC TGGLRGIARG GLAGLTLTSV YALYNNWEHM 200
    KGSLLQQSL 209
    Length:209
    Mass (Da):21,907
    Last modified:January 1, 1998 - v1
    Checksum:i54D3A8749F6EF21F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006451 mRNA. Translation: BAA21819.1.
    PIRiJE0154.
    RefSeqiNP_062225.1. NM_019352.2.
    UniGeneiRn.154974.
    Rn.2230.

    Genome annotation databases

    GeneIDi54312.
    KEGGirno:54312.
    UCSCiRGD:3863. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006451 mRNA. Translation: BAA21819.1 .
    PIRi JE0154.
    RefSeqi NP_062225.1. NM_019352.2.
    UniGenei Rn.154974.
    Rn.2230.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026932.

    Proteomic databases

    PaxDbi O35093.
    PRIDEi O35093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54312.
    KEGGi rno:54312.
    UCSCi RGD:3863. rat.

    Organism-specific databases

    CTDi 100287932.
    RGDi 3863. Timm23.

    Phylogenomic databases

    eggNOGi COG5596.
    HOGENOMi HOG000166435.
    HOVERGENi HBG057526.
    InParanoidi O35093.
    KOi K17794.
    PhylomeDBi O35093.

    Miscellaneous databases

    NextBioi 610982.

    Gene expression databases

    Genevestigatori O35093.

    Family and domain databases

    InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
    IPR005681. Tim23.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00983. 3a0801s02tim23. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44."
      Ishihara N., Mihara K.
      J. Biochem. 123:722-732(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiTIM23_RAT
    AccessioniPrimary (citable) accession number: O35093
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3