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Protein

Mitochondrial import inner membrane translocase subunit Tim17-A

Gene

Timm17a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of protein processing Source: RGD
  • protein import into mitochondrial matrix Source: GO_Central

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim17-A
Alternative name(s):
Inner membrane preprotein translocase Tim17a
Gene namesi
Name:Timm17a
Synonyms:Mimt17, Tim17, Tim17a, Timm17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi3862 Timm17a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei63 – 77HelicalSequence analysisAdd BLAST15
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102861 – 171Mitochondrial import inner membrane translocase subunit Tim17-AAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 78By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO35092
PRIDEiO35092

Expressioni

Gene expression databases

BgeeiENSRNOG00000007040
GenevisibleiO35092 RN

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, some TIM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 (By similarity).By similarity

Protein-protein interaction databases

CORUMiO35092
STRINGi10116.ENSRNOP00000009398

Structurei

3D structure databases

SMRiO35092
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1652 Eukaryota
COG5596 LUCA
GeneTreeiENSGT00390000017780
HOGENOMiHOG000183190
HOVERGENiHBG054233
InParanoidiO35092
KOiK17795
OMAiFASTQFP
OrthoDBiEOG091G0PGZ
PhylomeDBiO35092
TreeFamiTF106195

Family and domain databases

InterProiView protein in InterPro
IPR005678 Tim17
TIGRFAMsiTIGR00980 3a0801so1tim17, 1 hit

Sequencei

Sequence statusi: Complete.

O35092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAFKGFRNS PVGVNHRLRG
60 70 80 90 100
SLTAIKTRAP QLGGSFAVWG GLFSTIDCGM VQIRGKEDPW NSITSGALTG
110 120 130 140 150
AILAARNGPV AMVGSAAMGG ILLALIEGAG ILLTRFASAQ FPNGPQFAED
160 170
HSQLPSSQLP SSPFGDYRQY Q
Length:171
Mass (Da):18,038
Last modified:January 1, 1998 - v1
Checksum:i4873D1282A2469CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006450 mRNA Translation: BAA21818.1
PIRiJE0153
RefSeqiNP_062224.1, NM_019351.1
UniGeneiRn.22514

Genome annotation databases

EnsembliENSRNOT00000009398; ENSRNOP00000009398; ENSRNOG00000007040
GeneIDi54311
KEGGirno:54311
UCSCiRGD:3862 rat

Similar proteinsi

Entry informationi

Entry nameiTI17A_RAT
AccessioniPrimary (citable) accession number: O35092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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