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O35092 (TI17A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mitochondrial import inner membrane translocase subunit Tim17-A
Alternative name(s):
Inner membrane preprotein translocase Tim17a
Gene names
Name:Timm17a
Synonyms:Mimt17, Tim17, Tim17a, Timm17
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Subunit structure

Component of the TIM23 complex at least composed of TIMM23, some TIM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the Tim17/Tim22/Tim23 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 171171Mitochondrial import inner membrane translocase subunit Tim17-A
PRO_0000210286

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane63 – 8321Helical; Potential
Transmembrane113 – 13321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O35092 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 4873D1282A2469CC

FASTA17118,038
        10         20         30         40         50         60 
MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAFKGFRNS PVGVNHRLRG SLTAIKTRAP 

        70         80         90        100        110        120 
QLGGSFAVWG GLFSTIDCGM VQIRGKEDPW NSITSGALTG AILAARNGPV AMVGSAAMGG 

       130        140        150        160        170 
ILLALIEGAG ILLTRFASAQ FPNGPQFAED HSQLPSSQLP SSPFGDYRQY Q 

« Hide

References

[1]"Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44."
Ishihara N., Mihara K.
J. Biochem. 123:722-732(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006450 mRNA. Translation: BAA21818.1.
PIRJE0153.
RefSeqNP_062224.1. NM_019351.1.
UniGeneRn.22514.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009398.

Proteomic databases

PaxDbO35092.
PRIDEO35092.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009398; ENSRNOP00000009398; ENSRNOG00000007040.
GeneID54311.
KEGGrno:54311.
UCSCRGD:3862. rat.

Organism-specific databases

CTD10440.
RGD3862. Timm17a.

Phylogenomic databases

eggNOGCOG5596.
GeneTreeENSGT00390000017780.
HOGENOMHOG000183190.
HOVERGENHBG054233.
InParanoidO35092.
KOK17795.
OMAMRAPVLG.
OrthoDBEOG7JX35C.
PhylomeDBO35092.
TreeFamTF106195.

Gene expression databases

GenevestigatorO35092.

Family and domain databases

InterProIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsTIGR00980. 3a0801so1tim17. 1 hit.
ProtoNetSearch...

Other

NextBio610978.
PROO35092.

Entry information

Entry nameTI17A_RAT
AccessionPrimary (citable) accession number: O35092
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families