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O35092

- TI17A_RAT

UniProt

O35092 - TI17A_RAT

Protein

Mitochondrial import inner membrane translocase subunit Tim17-A

Gene

Timm17a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

    GO - Molecular functioni

    1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
    2. protein binding Source: RGD

    GO - Biological processi

    1. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_199211. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim17-A
    Alternative name(s):
    Inner membrane preprotein translocase Tim17a
    Gene namesi
    Name:Timm17a
    Synonyms:Mimt17, Tim17, Tim17a, Timm17
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi3862. Timm17a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: RGD
    3. mitochondrial inner membrane presequence translocase complex Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 171171Mitochondrial import inner membrane translocase subunit Tim17-APRO_0000210286Add
    BLAST

    Proteomic databases

    PaxDbiO35092.
    PRIDEiO35092.

    Expressioni

    Gene expression databases

    GenevestigatoriO35092.

    Interactioni

    Subunit structurei

    Component of the TIM23 complex at least composed of TIMM23, some TIM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009398.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tim17/Tim22/Tim23 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5596.
    GeneTreeiENSGT00390000017780.
    HOGENOMiHOG000183190.
    HOVERGENiHBG054233.
    InParanoidiO35092.
    KOiK17795.
    OMAiMRAPVLG.
    OrthoDBiEOG7JX35C.
    PhylomeDBiO35092.
    TreeFamiTF106195.

    Family and domain databases

    InterProiIPR005678. Tim17.
    IPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O35092-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAFKGFRNS PVGVNHRLRG    50
    SLTAIKTRAP QLGGSFAVWG GLFSTIDCGM VQIRGKEDPW NSITSGALTG 100
    AILAARNGPV AMVGSAAMGG ILLALIEGAG ILLTRFASAQ FPNGPQFAED 150
    HSQLPSSQLP SSPFGDYRQY Q 171
    Length:171
    Mass (Da):18,038
    Last modified:January 1, 1998 - v1
    Checksum:i4873D1282A2469CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006450 mRNA. Translation: BAA21818.1.
    PIRiJE0153.
    RefSeqiNP_062224.1. NM_019351.1.
    UniGeneiRn.22514.

    Genome annotation databases

    EnsembliENSRNOT00000009398; ENSRNOP00000009398; ENSRNOG00000007040.
    GeneIDi54311.
    KEGGirno:54311.
    UCSCiRGD:3862. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006450 mRNA. Translation: BAA21818.1 .
    PIRi JE0153.
    RefSeqi NP_062224.1. NM_019351.1.
    UniGenei Rn.22514.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009398.

    Proteomic databases

    PaxDbi O35092.
    PRIDEi O35092.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009398 ; ENSRNOP00000009398 ; ENSRNOG00000007040 .
    GeneIDi 54311.
    KEGGi rno:54311.
    UCSCi RGD:3862. rat.

    Organism-specific databases

    CTDi 10440.
    RGDi 3862. Timm17a.

    Phylogenomic databases

    eggNOGi COG5596.
    GeneTreei ENSGT00390000017780.
    HOGENOMi HOG000183190.
    HOVERGENi HBG054233.
    InParanoidi O35092.
    KOi K17795.
    OMAi MRAPVLG.
    OrthoDBi EOG7JX35C.
    PhylomeDBi O35092.
    TreeFami TF106195.

    Enzyme and pathway databases

    Reactomei REACT_199211. Mitochondrial protein import.

    Miscellaneous databases

    NextBioi 610978.
    PROi O35092.

    Gene expression databases

    Genevestigatori O35092.

    Family and domain databases

    InterProi IPR005678. Tim17.
    IPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00980. 3a0801so1tim17. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44."
      Ishihara N., Mihara K.
      J. Biochem. 123:722-732(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiTI17A_RAT
    AccessioniPrimary (citable) accession number: O35092
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3