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Protein

Mitochondrial import inner membrane translocase subunit Tim17-A

Gene

Timm17a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_199211. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim17-A
Alternative name(s):
Inner membrane preprotein translocase Tim17a
Gene namesi
Name:Timm17a
Synonyms:Mimt17, Tim17, Tim17a, Timm17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi3862. Timm17a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: RGD
  3. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Mitochondrial import inner membrane translocase subunit Tim17-APRO_0000210286Add
BLAST

Proteomic databases

PaxDbiO35092.
PRIDEiO35092.

Expressioni

Gene expression databases

GenevestigatoriO35092.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, some TIM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009398.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
HOVERGENiHBG054233.
InParanoidiO35092.
KOiK17795.
OMAiFSAFDCA.
OrthoDBiEOG7JX35C.
PhylomeDBiO35092.
TreeFamiTF106195.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.

Sequencei

Sequence statusi: Complete.

O35092-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAFKGFRNS PVGVNHRLRG
60 70 80 90 100
SLTAIKTRAP QLGGSFAVWG GLFSTIDCGM VQIRGKEDPW NSITSGALTG
110 120 130 140 150
AILAARNGPV AMVGSAAMGG ILLALIEGAG ILLTRFASAQ FPNGPQFAED
160 170
HSQLPSSQLP SSPFGDYRQY Q
Length:171
Mass (Da):18,038
Last modified:January 1, 1998 - v1
Checksum:i4873D1282A2469CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006450 mRNA. Translation: BAA21818.1.
PIRiJE0153.
RefSeqiNP_062224.1. NM_019351.1.
UniGeneiRn.22514.

Genome annotation databases

EnsembliENSRNOT00000009398; ENSRNOP00000009398; ENSRNOG00000007040.
GeneIDi54311.
KEGGirno:54311.
UCSCiRGD:3862. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006450 mRNA. Translation: BAA21818.1.
PIRiJE0153.
RefSeqiNP_062224.1. NM_019351.1.
UniGeneiRn.22514.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009398.

Proteomic databases

PaxDbiO35092.
PRIDEiO35092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009398; ENSRNOP00000009398; ENSRNOG00000007040.
GeneIDi54311.
KEGGirno:54311.
UCSCiRGD:3862. rat.

Organism-specific databases

CTDi10440.
RGDi3862. Timm17a.

Phylogenomic databases

eggNOGiCOG5596.
GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
HOVERGENiHBG054233.
InParanoidiO35092.
KOiK17795.
OMAiFSAFDCA.
OrthoDBiEOG7JX35C.
PhylomeDBiO35092.
TreeFamiTF106195.

Enzyme and pathway databases

ReactomeiREACT_199211. Mitochondrial protein import.

Miscellaneous databases

NextBioi610978.
PROiO35092.

Gene expression databases

GenevestigatoriO35092.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44."
    Ishihara N., Mihara K.
    J. Biochem. 123:722-732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTI17A_RAT
AccessioniPrimary (citable) accession number: O35092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.