Skip Header

Contribute Send feedback
Read comments (?) or add your own

O35090 (ALBU_MERUN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serum albumin
Gene names
Name:ALB
OrganismMeriones unguiculatus (Mongolian jird) (Mongolian gerbil)
Taxonomic identifier10047 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Gerbillinae › Meriones

Protein attributes

Sequence length609 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Subcellular location

Secreted.

Tissue specificity

Plasma.

Post-translational modification

Phosphorylation sites are present in the extracellular medium By similarity.

Sequence similarities

Belongs to the ALB/AFP/VDB family.

Contains 3 albumin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Propeptide19 – 224 By similarity
PRO_0000001071
Chain25 – 609585Serum albumin
PRO_0000001072

Regions

Domain20 – 212193Albumin 1
Domain213 – 404192Albumin 2
Domain405 – 602198Albumin 3

Sites

Metal binding281Copper
Metal binding921Zinc By similarity
Metal binding1241Zinc By similarity
Metal binding2721Zinc By similarity
Metal binding2741Zinc By similarity

Amino acid modifications

Modified residue831Phosphoserine By similarity
Modified residue4441Phosphoserine By similarity
Modified residue4451Phosphothreonine By similarity
Modified residue4471Phosphothreonine By similarity
Disulfide bond78 ↔ 87 By similarity
Disulfide bond100 ↔ 116 By similarity
Disulfide bond115 ↔ 126 By similarity
Disulfide bond149 ↔ 194 By similarity
Disulfide bond193 ↔ 202 By similarity
Disulfide bond225 ↔ 271 By similarity
Disulfide bond270 ↔ 278 By similarity
Disulfide bond290 ↔ 304 By similarity
Disulfide bond303 ↔ 314 By similarity
Disulfide bond341 ↔ 386 By similarity
Disulfide bond385 ↔ 394 By similarity
Disulfide bond417 ↔ 463 By similarity
Disulfide bond462 ↔ 473 By similarity
Disulfide bond486 ↔ 502 By similarity
Disulfide bond501 ↔ 512 By similarity
Disulfide bond539 ↔ 584 By similarity
Disulfide bond583 ↔ 592 By similarity

Sequences

Sequence LengthMass (Da)Tools
O35090 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9CA5F97F67EF1A48

FASTA60968,941
        10         20         30         40         50         60 
MKWVTFLLLL FVSGSAFSRG VFRRDAAHKS EIAHRYKDLG EKYFKGLVLY TFSQYLQKCS 

        70         80         90        100        110        120 
YEEHVKLVRE VTDFASNCAK DESAENCDKS LHTLFGDKLC SLPNFGEKYA EMADCCAKQE 

       130        140        150        160        170        180 
PERNECFLQH KDDNPQLPPF KRAEPDAMCT AFQENAEAFM GHYLHEVARR HPYFYGPELL 

       190        200        210        220        230        240 
YLADKYTAVL TECCAADDKG ACLTPKLDAL KEKALVSAVR QRLKCSSMKK FGERAFKAWA 

       250        260        270        280        290        300 
VARMSQTFPN ADFAEITKLA TDLTKVTQEC CHGDLLECAD DRAELAKYMC ENQASISSKL 

       310        320        330        340        350        360 
QACCDKEMLQ KSQCLAEVEH DDMPADLPAL TADFVEDKDV CKNYAEAKDV FLGTFLYEYS 

       370        380        390        400        410        420 
RRHPEYSVSL LLRLAKKYEA TLEKCCAEAD PHACYGHVFD EFKPLVEEPQ NLVKSNCELY 

       430        440        450        460        470        480 
EKLGEYGFQN AVLVRYTKKA PQVSTPTLVE AARSLGRVGT HCCALPEKKR LPCVEDYLSA 

       490        500        510        520        530        540 
ILNRVCLLHE KTPVSEQVTK CCSGSLVERR PCFSALPVDE TYVPKEFKAE TFTFHANICT 

       550        560        570        580        590        600 
LPEKEKQMEK QTALAELVKH KPQATEEQLK KVMGDFAEFL EKCCKQEDKE ACFSTEGPKL 


VAESQKALA

« Hide

References

[1]"Sequencing of cDNA encoding serum albumin and its extrahepatic synthesis in the Mongolian gerbil, Meriones unguiculatus."
Yoshida K., Seto-Ohshima A., Sinohara H.
DNA Res. 4:351-354(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: MGS IDR.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB006197 mRNA. Translation: BAA21765.1.
PIRJC5838.

3D structure databases

ProteinModelPortalO35090.
SMRO35090. Positions 27-609.
ModBaseSearch...

Proteomic databases

PRIDEO35090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004207.

Family and domain databases

InterProIPR000264. ALB/AFP/VDB.
IPR001703. Alpha-fetoprotein.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMSSF48552. Serum_albumin. 3 hits.
PROSITEPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALBU_MERUN
AccessionPrimary (citable) accession number: O35090
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents