Homeobox protein ARX - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot O35085 (ARX_MOUSE)

Last modified January 19, 2010. Version 84. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Homeobox protein ARX
Alternative name(s):
Aristaless-related homeobox

Gene names

Name:

Arx

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function

Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Contains 1 homeobox DNA-binding domain.

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Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	axon guidance Inferred from mutant phenotype. Source: MGI cell proliferation in forebrain Inferred from mutant phenotype. Source: MGI cerebral cortex GABAergic interneuron migration Inferred from mutant phenotype. Source: MGI cerebral cortex tangential migration Inferred from mutant phenotype. Source: MGI embryonic olfactory bulb interneuron precursor migration Inferred from mutant phenotype. Source: MGI globus pallidus development Inferred from mutant phenotype. Source: MGI neuron migration Inferred from mutant phenotype. Source: MGI positive regulation of organ growth Inferred from mutant phenotype. Source: MGI regulation of cell proliferation Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 564

564

Homeobox protein ARX

PRO_0000048820

Regions

DNA binding

330 – 389

Homeobox

Motif

531 – 544

OAR

Compositional bias

100 – 154

Ala-rich

Compositional bias

223 – 252

Glu-rich

Compositional bias

397 – 461

Pro-rich

Compositional bias

427 – 546

120

Ala-rich

Experimental info

Sequence conflict

D → E in BAA85852. Ref.3

Sequence conflict

127

P → H in BAA85852. Ref.3

Sequence conflict

316

S → A in BAA85852. Ref.3

Sequence conflict

360

Missing in BAA85852. Ref.3

Sequence conflict

485

Missing in BAA85852. Ref.3

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Sequences

Sequence

Length

Mass (Da)

Tools

O35085-1 [UniParc].

Last modified January 27, 2003. Version 3.
Checksum: 74FEBBD3BA92B39C
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FASTA

564

58,490

        10         20         30         40         50         60 
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL PAPLASRADQ 

        70         80         90        100        110        120 
EKAMQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA AAAAAAAAAA AAAATATGTA 

       130        140        150        160        170        180 
GPRGEVPPPP PPAARPGERQ DSAGAVAAAA AAAAWDTLKI SQAPQVSISR SKSYRENGAP 

       190        200        210        220        230        240 
FVPPPPALDE LSGPGGVAHP EERLSAASGP GSAPAAGGGT GAEDDEEELL EDEEDEEEEE 

       250        260        270        280        290        300 
ELLEDDDEEL LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAVATEGGE LSPKEELLLH 

       310        320        330        340        350        360 
PEDAEGKDGE DSVCLSAGSD SEEGLLKRKQ RRYRTTFTSY QLEELERAFQ KTHYPDVFTR 

       370        380        390        400        410        420 
EELAMRLDLT EARVQVWFQN RRAKWRKREK AGAQTHPPGL PFPGPLSATH PLSPYLDASP 

       430        440        450        460        470        480 
FPPHHPALDS AWTAAAAAAA AAFPSLPPPP GSASLPPSGA PLGLSTFLGA AVFRHPAFIS 

       490        500        510        520        530        540 
PAFGRLFSTM APLTSASTAA ALLRQPTPAV EGAVASGALA DPATAAADRR ASSIAALRLK 

       550        560 
AKEHAAQLTQ LNILPGTSTG KEVC

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate." Miura H., Yanazawa M., Kato K., Kitamura K. Mech. Dev. 65:99-109(1997) [PubMed: 9256348] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Kitamura K. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 391 AND 442.
[3]	"Homeobox genes and nervous development." Ohsaki K. Thesis (1999), Nara Institute of Science and Technology, Japan Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AB006103 mRNA. Translation: BAA28284.2. AB026674 Genomic DNA. Translation: BAA85852.1. AL590876 Genomic DNA. Translation: CAM25902.1. BC052033 mRNA. Translation: AAH52033.1.
IPI	IPI00126550.
RefSeq	NP_031518.2.
UniGene	Mm.275547
3D structure databases
SMR	O35085. Positions 329-391.
ModBase	Search...
Proteomic databases
PRIDE	O35085.
Genome annotation databases
Ensembl	ENSMUST00000046565; ENSMUSP00000049039; ENSMUSG00000035277; Mus musculus. [Genome view] ENSMUST00000113947; ENSMUSP00000109580; ENSMUSG00000035277; Mus musculus. [Genome view]
GeneID	11878.
KEGG	mmu:11878.
UCSC	uc009tsq.1. mouse.
Organism-specific databases
CTD	11878.
MGI	MGI:1097716. Arx.
Phylogenomic databases
eggNOG	roNOG15769.
HOGENOM	HBG715732.
HOVERGEN	O35085.
InParanoid	O35085.
OMA	RRSPCKV.
OrthoDB	EOG99W51F.
PhylomeDB	O35085.
Gene expression databases
ArrayExpress	O35085.
Bgee	O35085.
CleanEx	MM_ARX.
Genevestigator	O35085.
GermOnline	ENSMUSG00000035277. Mus musculus.
Family and domain databases
InterPro	IPR003654. Homeo_OAR. IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF03826. OAR. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS50803. OAR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	279907.
SOURCE	Search...

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Entry information

Entry name

ARX_MOUSE

Accession

Primary (citable) accession number: O35085
Secondary accession number(s): A2A4G9, Q9QYT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 27, 2003
Last modified:	January 19, 2010
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents