Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O35085 (ARX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein ARX
Alternative name(s):
Aristaless-related homeobox
Gene names
Name:Arx
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from mutant phenotype PubMed 15677725PubMed 17460091. Source: MGI

cell proliferation in forebrain

Inferred from mutant phenotype PubMed 15677725. Source: MGI

cerebral cortex GABAergic interneuron migration

Inferred from mutant phenotype PubMed 17460091. Source: MGI

cerebral cortex tangential migration

Inferred from mutant phenotype PubMed 17460091. Source: MGI

embryonic olfactory bulb interneuron precursor migration

Inferred from mutant phenotype PubMed 15677725. Source: MGI

epithelial cell fate commitment

Inferred from mutant phenotype PubMed 22387004. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 12379852. Source: MGI

globus pallidus development

Inferred from mutant phenotype PubMed 17460091. Source: MGI

lipid digestion

Inferred from mutant phenotype PubMed 22387004. Source: MGI

neuron migration

Inferred from mutant phenotype PubMed 12379852. Source: MGI

olfactory bulb development

Inferred from mutant phenotype PubMed 15677725. Source: MGI

positive regulation of organ growth

Inferred from mutant phenotype PubMed 15677725. Source: MGI

regulation of cell proliferation

Inferred from mutant phenotype PubMed 12379852. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred by curator PubMed 21966449. Source: MGI

   Molecular_functionchromatin binding

Inferred from direct assay PubMed 21966449. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Homeobox protein ARX
PRO_0000048820

Regions

DNA binding330 – 38960Homeobox
Motif532 – 54514OAR
Compositional bias100 – 15455Ala-rich
Compositional bias223 – 25230Glu-rich
Compositional bias397 – 46165Pro-rich
Compositional bias427 – 546120Ala-rich

Experimental info

Sequence conflict591D → E in BAA85852. Ref.3
Sequence conflict1271P → H in BAA85852. Ref.3
Sequence conflict3161S → A in BAA85852. Ref.3
Sequence conflict3601Missing in BAA85852. Ref.3
Sequence conflict4851Missing in BAA85852. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O35085 [UniParc].

Last modified January 27, 2003. Version 3.
Checksum: 74FEBBD3BA92B39C

FASTA56458,490
        10         20         30         40         50         60 
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL PAPLASRADQ 

        70         80         90        100        110        120 
EKAMQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA AAAAAAAAAA AAAATATGTA 

       130        140        150        160        170        180 
GPRGEVPPPP PPAARPGERQ DSAGAVAAAA AAAAWDTLKI SQAPQVSISR SKSYRENGAP 

       190        200        210        220        230        240 
FVPPPPALDE LSGPGGVAHP EERLSAASGP GSAPAAGGGT GAEDDEEELL EDEEDEEEEE 

       250        260        270        280        290        300 
ELLEDDDEEL LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAVATEGGE LSPKEELLLH 

       310        320        330        340        350        360 
PEDAEGKDGE DSVCLSAGSD SEEGLLKRKQ RRYRTTFTSY QLEELERAFQ KTHYPDVFTR 

       370        380        390        400        410        420 
EELAMRLDLT EARVQVWFQN RRAKWRKREK AGAQTHPPGL PFPGPLSATH PLSPYLDASP 

       430        440        450        460        470        480 
FPPHHPALDS AWTAAAAAAA AAFPSLPPPP GSASLPPSGA PLGLSTFLGA AVFRHPAFIS 

       490        500        510        520        530        540 
PAFGRLFSTM APLTSASTAA ALLRQPTPAV EGAVASGALA DPATAAADRR ASSIAALRLK 

       550        560 
AKEHAAQLTQ LNILPGTSTG KEVC 

« Hide

References

« Hide 'large scale' references
[1]"Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate."
Miura H., Yanazawa M., Kato K., Kitamura K.
Mech. Dev. 65:99-109(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Kitamura K.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 391 AND 442.
[3]"Homeobox genes and nervous development."
Ohsaki K.
Thesis (1999), Nara Institute of Science and Technology, Japan
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006103 mRNA. Translation: BAA28284.2.
AB026674 Genomic DNA. Translation: BAA85852.1.
AL590876 Genomic DNA. Translation: CAM25902.1.
BC052033 mRNA. Translation: AAH52033.1.
CCDSCCDS30271.1.
RefSeqNP_031518.2. NM_007492.3.
XP_006527814.1. XM_006527751.1.
UniGeneMm.275547.

3D structure databases

ProteinModelPortalO35085.
SMRO35085. Positions 331-387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000049039.

PTM databases

PhosphoSiteO35085.

Proteomic databases

PRIDEO35085.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046565; ENSMUSP00000049039; ENSMUSG00000035277.
ENSMUST00000113947; ENSMUSP00000109580; ENSMUSG00000035277.
GeneID11878.
KEGGmmu:11878.
UCSCuc009tsq.1. mouse.

Organism-specific databases

CTD170302.
MGIMGI:1097716. Arx.

Phylogenomic databases

eggNOGNOG313402.
GeneTreeENSGT00750000117318.
HOGENOMHOG000012381.
HOVERGENHBG004285.
InParanoidO35085.
KOK09452.
OMACKVRLIG.
OrthoDBEOG7XPZ60.
PhylomeDBO35085.
TreeFamTF350743.

Gene expression databases

BgeeO35085.
CleanExMM_ARX.
GenevestigatorO35085.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279907.
PROO35085.
SOURCESearch...

Entry information

Entry nameARX_MOUSE
AccessionPrimary (citable) accession number: O35085
Secondary accession number(s): A2A4G9, Q9QYT4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 27, 2003
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot