Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35085

- ARX_MOUSE

UniProt

O35085 - ARX_MOUSE

Protein

Homeobox protein ARX

Gene

Arx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (27 Jan 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi330 – 38960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. axon guidance Source: MGI
    2. cell proliferation in forebrain Source: MGI
    3. cerebral cortex GABAergic interneuron migration Source: MGI
    4. cerebral cortex tangential migration Source: MGI
    5. embryonic olfactory bulb interneuron precursor migration Source: MGI
    6. epithelial cell fate commitment Source: MGI
    7. forebrain development Source: MGI
    8. globus pallidus development Source: MGI
    9. lipid digestion Source: MGI
    10. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    11. neuron migration Source: MGI
    12. olfactory bulb development Source: MGI
    13. positive regulation of organ growth Source: MGI
    14. regulation of cell proliferation Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein ARX
    Alternative name(s):
    Aristaless-related homeobox
    Gene namesi
    Name:Arx
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1097716. Arx.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Homeobox protein ARXPRO_0000048820Add
    BLAST

    Proteomic databases

    PRIDEiO35085.

    PTM databases

    PhosphoSiteiO35085.

    Expressioni

    Gene expression databases

    BgeeiO35085.
    CleanExiMM_ARX.
    GenevestigatoriO35085.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000049039.

    Structurei

    3D structure databases

    ProteinModelPortaliO35085.
    SMRiO35085. Positions 331-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi532 – 54514OARAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi100 – 15455Ala-richAdd
    BLAST
    Compositional biasi223 – 25230Glu-richAdd
    BLAST
    Compositional biasi397 – 46165Pro-richAdd
    BLAST
    Compositional biasi427 – 546120Ala-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG313402.
    GeneTreeiENSGT00750000117318.
    HOGENOMiHOG000012381.
    HOVERGENiHBG004285.
    InParanoidiO35085.
    KOiK09452.
    OMAiCKVRLIG.
    OrthoDBiEOG7XPZ60.
    PhylomeDBiO35085.
    TreeFamiTF350743.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003654. OAR_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35085-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL    50
    PAPLASRADQ EKAMQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA 100
    AAAAAAAAAA AAAATATGTA GPRGEVPPPP PPAARPGERQ DSAGAVAAAA 150
    AAAAWDTLKI SQAPQVSISR SKSYRENGAP FVPPPPALDE LSGPGGVAHP 200
    EERLSAASGP GSAPAAGGGT GAEDDEEELL EDEEDEEEEE ELLEDDDEEL 250
    LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAVATEGGE LSPKEELLLH 300
    PEDAEGKDGE DSVCLSAGSD SEEGLLKRKQ RRYRTTFTSY QLEELERAFQ 350
    KTHYPDVFTR EELAMRLDLT EARVQVWFQN RRAKWRKREK AGAQTHPPGL 400
    PFPGPLSATH PLSPYLDASP FPPHHPALDS AWTAAAAAAA AAFPSLPPPP 450
    GSASLPPSGA PLGLSTFLGA AVFRHPAFIS PAFGRLFSTM APLTSASTAA 500
    ALLRQPTPAV EGAVASGALA DPATAAADRR ASSIAALRLK AKEHAAQLTQ 550
    LNILPGTSTG KEVC 564
    Length:564
    Mass (Da):58,490
    Last modified:January 27, 2003 - v3
    Checksum:i74FEBBD3BA92B39C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591D → E in BAA85852. 1 PublicationCurated
    Sequence conflicti127 – 1271P → H in BAA85852. 1 PublicationCurated
    Sequence conflicti316 – 3161S → A in BAA85852. 1 PublicationCurated
    Sequence conflicti360 – 3601Missing in BAA85852. 1 PublicationCurated
    Sequence conflicti485 – 4851Missing in BAA85852. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006103 mRNA. Translation: BAA28284.2.
    AB026674 Genomic DNA. Translation: BAA85852.1.
    AL590876 Genomic DNA. Translation: CAM25902.1.
    BC052033 mRNA. Translation: AAH52033.1.
    CCDSiCCDS30271.1.
    RefSeqiNP_031518.2. NM_007492.3.
    XP_006527814.1. XM_006527751.1.
    UniGeneiMm.275547.

    Genome annotation databases

    EnsembliENSMUST00000046565; ENSMUSP00000049039; ENSMUSG00000035277.
    ENSMUST00000113947; ENSMUSP00000109580; ENSMUSG00000035277.
    GeneIDi11878.
    KEGGimmu:11878.
    UCSCiuc009tsq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006103 mRNA. Translation: BAA28284.2 .
    AB026674 Genomic DNA. Translation: BAA85852.1 .
    AL590876 Genomic DNA. Translation: CAM25902.1 .
    BC052033 mRNA. Translation: AAH52033.1 .
    CCDSi CCDS30271.1.
    RefSeqi NP_031518.2. NM_007492.3.
    XP_006527814.1. XM_006527751.1.
    UniGenei Mm.275547.

    3D structure databases

    ProteinModelPortali O35085.
    SMRi O35085. Positions 331-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000049039.

    PTM databases

    PhosphoSitei O35085.

    Proteomic databases

    PRIDEi O35085.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046565 ; ENSMUSP00000049039 ; ENSMUSG00000035277 .
    ENSMUST00000113947 ; ENSMUSP00000109580 ; ENSMUSG00000035277 .
    GeneIDi 11878.
    KEGGi mmu:11878.
    UCSCi uc009tsq.1. mouse.

    Organism-specific databases

    CTDi 170302.
    MGIi MGI:1097716. Arx.

    Phylogenomic databases

    eggNOGi NOG313402.
    GeneTreei ENSGT00750000117318.
    HOGENOMi HOG000012381.
    HOVERGENi HBG004285.
    InParanoidi O35085.
    KOi K09452.
    OMAi CKVRLIG.
    OrthoDBi EOG7XPZ60.
    PhylomeDBi O35085.
    TreeFami TF350743.

    Miscellaneous databases

    NextBioi 279907.
    PROi O35085.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35085.
    CleanExi MM_ARX.
    Genevestigatori O35085.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003654. OAR_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate."
      Miura H., Yanazawa M., Kato K., Kitamura K.
      Mech. Dev. 65:99-109(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Kitamura K.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 391 AND 442.
    3. "Homeobox genes and nervous development."
      Ohsaki K.
      Thesis (1999), Nara Institute of Science and Technology, Japan
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiARX_MOUSE
    AccessioniPrimary (citable) accession number: O35085
    Secondary accession number(s): A2A4G9, Q9QYT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 27, 2003
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3