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O35085

- ARX_MOUSE

UniProt

O35085 - ARX_MOUSE

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Protein

Homeobox protein ARX

Gene

Arx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi330 – 38960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. axon guidance Source: MGI
  2. cell proliferation in forebrain Source: MGI
  3. cerebral cortex GABAergic interneuron migration Source: MGI
  4. cerebral cortex tangential migration Source: MGI
  5. embryonic olfactory bulb interneuron precursor migration Source: MGI
  6. epithelial cell fate commitment Source: MGI
  7. forebrain development Source: MGI
  8. globus pallidus development Source: MGI
  9. lipid digestion Source: MGI
  10. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  11. neuron migration Source: MGI
  12. olfactory bulb development Source: MGI
  13. positive regulation of organ growth Source: MGI
  14. regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ARX
Alternative name(s):
Aristaless-related homeobox
Gene namesi
Name:Arx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1097716. Arx.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Homeobox protein ARXPRO_0000048820Add
BLAST

Proteomic databases

PRIDEiO35085.

PTM databases

PhosphoSiteiO35085.

Expressioni

Gene expression databases

BgeeiO35085.
CleanExiMM_ARX.
GenevestigatoriO35085.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049039.

Structurei

3D structure databases

ProteinModelPortaliO35085.
SMRiO35085. Positions 331-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi532 – 54514OARAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 15455Ala-richAdd
BLAST
Compositional biasi223 – 25230Glu-richAdd
BLAST
Compositional biasi397 – 46165Pro-richAdd
BLAST
Compositional biasi427 – 546120Ala-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG313402.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000012381.
HOVERGENiHBG004285.
InParanoidiO35085.
KOiK09452.
OMAiCKVRLIG.
OrthoDBiEOG7XPZ60.
PhylomeDBiO35085.
TreeFamiTF350743.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35085-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL
60 70 80 90 100
PAPLASRADQ EKAMQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA
110 120 130 140 150
AAAAAAAAAA AAAATATGTA GPRGEVPPPP PPAARPGERQ DSAGAVAAAA
160 170 180 190 200
AAAAWDTLKI SQAPQVSISR SKSYRENGAP FVPPPPALDE LSGPGGVAHP
210 220 230 240 250
EERLSAASGP GSAPAAGGGT GAEDDEEELL EDEEDEEEEE ELLEDDDEEL
260 270 280 290 300
LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAVATEGGE LSPKEELLLH
310 320 330 340 350
PEDAEGKDGE DSVCLSAGSD SEEGLLKRKQ RRYRTTFTSY QLEELERAFQ
360 370 380 390 400
KTHYPDVFTR EELAMRLDLT EARVQVWFQN RRAKWRKREK AGAQTHPPGL
410 420 430 440 450
PFPGPLSATH PLSPYLDASP FPPHHPALDS AWTAAAAAAA AAFPSLPPPP
460 470 480 490 500
GSASLPPSGA PLGLSTFLGA AVFRHPAFIS PAFGRLFSTM APLTSASTAA
510 520 530 540 550
ALLRQPTPAV EGAVASGALA DPATAAADRR ASSIAALRLK AKEHAAQLTQ
560
LNILPGTSTG KEVC
Length:564
Mass (Da):58,490
Last modified:January 27, 2003 - v3
Checksum:i74FEBBD3BA92B39C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591D → E in BAA85852. 1 PublicationCurated
Sequence conflicti127 – 1271P → H in BAA85852. 1 PublicationCurated
Sequence conflicti316 – 3161S → A in BAA85852. 1 PublicationCurated
Sequence conflicti360 – 3601Missing in BAA85852. 1 PublicationCurated
Sequence conflicti485 – 4851Missing in BAA85852. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006103 mRNA. Translation: BAA28284.2.
AB026674 Genomic DNA. Translation: BAA85852.1.
AL590876 Genomic DNA. Translation: CAM25902.1.
BC052033 mRNA. Translation: AAH52033.1.
CCDSiCCDS30271.1.
RefSeqiNP_031518.2. NM_007492.3.
XP_006527814.1. XM_006527751.1.
UniGeneiMm.275547.

Genome annotation databases

EnsembliENSMUST00000046565; ENSMUSP00000049039; ENSMUSG00000035277.
ENSMUST00000113947; ENSMUSP00000109580; ENSMUSG00000035277.
GeneIDi11878.
KEGGimmu:11878.
UCSCiuc009tsq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006103 mRNA. Translation: BAA28284.2 .
AB026674 Genomic DNA. Translation: BAA85852.1 .
AL590876 Genomic DNA. Translation: CAM25902.1 .
BC052033 mRNA. Translation: AAH52033.1 .
CCDSi CCDS30271.1.
RefSeqi NP_031518.2. NM_007492.3.
XP_006527814.1. XM_006527751.1.
UniGenei Mm.275547.

3D structure databases

ProteinModelPortali O35085.
SMRi O35085. Positions 331-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000049039.

PTM databases

PhosphoSitei O35085.

Proteomic databases

PRIDEi O35085.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046565 ; ENSMUSP00000049039 ; ENSMUSG00000035277 .
ENSMUST00000113947 ; ENSMUSP00000109580 ; ENSMUSG00000035277 .
GeneIDi 11878.
KEGGi mmu:11878.
UCSCi uc009tsq.1. mouse.

Organism-specific databases

CTDi 170302.
MGIi MGI:1097716. Arx.

Phylogenomic databases

eggNOGi NOG313402.
GeneTreei ENSGT00760000118958.
HOGENOMi HOG000012381.
HOVERGENi HBG004285.
InParanoidi O35085.
KOi K09452.
OMAi CKVRLIG.
OrthoDBi EOG7XPZ60.
PhylomeDBi O35085.
TreeFami TF350743.

Miscellaneous databases

NextBioi 279907.
PROi O35085.
SOURCEi Search...

Gene expression databases

Bgeei O35085.
CleanExi MM_ARX.
Genevestigatori O35085.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate."
    Miura H., Yanazawa M., Kato K., Kitamura K.
    Mech. Dev. 65:99-109(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Kitamura K.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 391 AND 442.
  3. "Homeobox genes and nervous development."
    Ohsaki K.
    Thesis (1999), Nara Institute of Science and Technology, Japan
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiARX_MOUSE
AccessioniPrimary (citable) accession number: O35085
Secondary accession number(s): A2A4G9, Q9QYT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 27, 2003
Last modified: October 29, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3