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Protein

Homeobox protein ARX

Gene

Arx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi330 – 389HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: MGI
  • cell proliferation in forebrain Source: MGI
  • cerebral cortex GABAergic interneuron migration Source: MGI
  • cerebral cortex tangential migration Source: MGI
  • embryonic olfactory bulb interneuron precursor migration Source: MGI
  • epithelial cell fate commitment Source: MGI
  • forebrain development Source: MGI
  • globus pallidus development Source: MGI
  • lipid digestion Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • neuron migration Source: MGI
  • olfactory bulb development Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of organ growth Source: MGI
  • regulation of cell proliferation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ARX
Alternative name(s):
Aristaless-related homeobox
Gene namesi
Name:Arx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1097716. Arx.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488201 – 564Homeobox protein ARXAdd BLAST564

Proteomic databases

PaxDbiO35085.
PRIDEiO35085.

PTM databases

PhosphoSitePlusiO35085.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035277.
CleanExiMM_ARX.
GenevisibleiO35085. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049039.

Structurei

3D structure databases

ProteinModelPortaliO35085.
SMRiO35085.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi532 – 545OARPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 154Ala-richAdd BLAST55
Compositional biasi223 – 252Glu-richAdd BLAST30
Compositional biasi397 – 461Pro-richAdd BLAST65
Compositional biasi427 – 546Ala-richAdd BLAST120

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00900000140809.
HOGENOMiHOG000012381.
HOVERGENiHBG004285.
InParanoidiO35085.
KOiK09452.
OMAiIGPTFGR.
OrthoDBiEOG091G0S4E.
PhylomeDBiO35085.
TreeFamiTF350743.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR003654. OAR_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.

Sequencei

Sequence statusi: Complete.

O35085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL
60 70 80 90 100
PAPLASRADQ EKAMQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA
110 120 130 140 150
AAAAAAAAAA AAAATATGTA GPRGEVPPPP PPAARPGERQ DSAGAVAAAA
160 170 180 190 200
AAAAWDTLKI SQAPQVSISR SKSYRENGAP FVPPPPALDE LSGPGGVAHP
210 220 230 240 250
EERLSAASGP GSAPAAGGGT GAEDDEEELL EDEEDEEEEE ELLEDDDEEL
260 270 280 290 300
LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAVATEGGE LSPKEELLLH
310 320 330 340 350
PEDAEGKDGE DSVCLSAGSD SEEGLLKRKQ RRYRTTFTSY QLEELERAFQ
360 370 380 390 400
KTHYPDVFTR EELAMRLDLT EARVQVWFQN RRAKWRKREK AGAQTHPPGL
410 420 430 440 450
PFPGPLSATH PLSPYLDASP FPPHHPALDS AWTAAAAAAA AAFPSLPPPP
460 470 480 490 500
GSASLPPSGA PLGLSTFLGA AVFRHPAFIS PAFGRLFSTM APLTSASTAA
510 520 530 540 550
ALLRQPTPAV EGAVASGALA DPATAAADRR ASSIAALRLK AKEHAAQLTQ
560
LNILPGTSTG KEVC
Length:564
Mass (Da):58,490
Last modified:January 27, 2003 - v3
Checksum:i74FEBBD3BA92B39C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59D → E in BAA85852 (Ref. 3) Curated1
Sequence conflicti127P → H in BAA85852 (Ref. 3) Curated1
Sequence conflicti316S → A in BAA85852 (Ref. 3) Curated1
Sequence conflicti360Missing in BAA85852 (Ref. 3) Curated1
Sequence conflicti485Missing in BAA85852 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006103 mRNA. Translation: BAA28284.2.
AB026674 Genomic DNA. Translation: BAA85852.1.
AL590876 Genomic DNA. Translation: CAM25902.1.
BC052033 mRNA. Translation: AAH52033.1.
CCDSiCCDS30271.1.
RefSeqiNP_001292869.1. NM_001305940.1.
NP_031518.2. NM_007492.4.
UniGeneiMm.275547.

Genome annotation databases

EnsembliENSMUST00000046565; ENSMUSP00000049039; ENSMUSG00000035277.
ENSMUST00000113947; ENSMUSP00000109580; ENSMUSG00000035277.
GeneIDi11878.
KEGGimmu:11878.
UCSCiuc009tsq.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiARX_MOUSE
AccessioniPrimary (citable) accession number: O35085
Secondary accession number(s): A2A4G9, Q9QYT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 27, 2003
Last modified: November 22, 2017
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families