Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35082

- KLOT_MOUSE

UniProt

O35082 - KLOT_MOUSE

Protein

Klotho

Gene

Kl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.
    The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

    Catalytic activityi

    A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.1 Publication

    Enzyme regulationi

    Inhibited by D-saccharic acid 1,4-lactone and taurocholic acid.1 Publication

    Kineticsi

    1. KM=0.249 mM for 4-methylumbelliferylglucuronide1 Publication
    2. KM=0.251 mM for estrone 3-beta-D-glucuronide1 Publication
    3. KM=0.174 mM for beta-estradiol 3-beta-D-glucuronide1 Publication
    4. KM=0.251 mM for estriol 3-beta-D-glucuronide1 Publication

    Vmax=0.62 µM/h/µg enzyme1 Publication

    pH dependencei

    Optimum pH is 5.5.1 Publication

    GO - Molecular functioni

    1. beta-glucuronidase activity Source: UniProtKB-EC
    2. fibroblast growth factor binding Source: UniProtKB
    3. fibroblast growth factor receptor binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. signal transducer activity Source: InterPro

    GO - Biological processi

    1. acute inflammatory response Source: Ensembl
    2. aging Source: MGI
    3. calcium ion homeostasis Source: MGI
    4. carbohydrate metabolic process Source: InterPro
    5. energy reserve metabolic process Source: MGI
    6. insulin receptor signaling pathway Source: InterPro
    7. positive regulation of bone mineralization Source: Ensembl
    8. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_202336. FGFR1c and Klotho ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Klotho (EC:3.2.1.31)
    Cleaved into the following chain:
    Gene namesi
    Name:Kl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1101771. Kl.

    Subcellular locationi

    Isoform 1 : Cell membrane; Single-pass type I membrane protein
    Note: Isoform 1 shedding leads to a soluble peptide.

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: InterPro
    3. integral component of membrane Source: MGI
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice display a syndrome resembling to human aging, with short lifespan, infertility, atherosclerosis, skin atrophy, osteoporosis and emphysema. They have various metabolic abnormalities, including increased insulin sensitivity and decreased insulin production. Mice overexpressing Kl have increased resistance to insulin and IGF1, a lifespan extended of more than 20%, and generate fewer offspring.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 1014980KlothoPRO_0000042247Add
    BLAST
    Chaini35 – ?Klotho peptidePRO_0000042248

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi614 – 6141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO35082.
    PRIDEiO35082.

    PTM databases

    PhosphoSiteiO35082.

    Expressioni

    Tissue specificityi

    Membrane-bound protein is present in distal renal tubules, inner ear, ependymal cells of brain choroid plexus, elongating spermatids and mature oocytes (at protein level). Soluble peptide is present in serum (100 pM) and cerebrospinal fluid. Expressed strongly in kidney, moderately in brain choroid plexus, and at low levels in pituitary, placenta, skeletal muscle, urinary bladder, aorta, pancreas, testis, ovary, colon, thyroid gland and adipocytes.8 Publications

    Developmental stagei

    Not expressed in the embryo. Expressed in the kidney of newborns.1 Publication

    Inductioni

    Induced by 1,25-dihydroxyvitamin D3 in kidney. Down-regulated by angiotensin II and up-regulated by statins through modulation of the RhoA pathway in epithelial cells (in vitro). Isoform 1 (but not isoform 2) is up-regulated by thyroid hormone in adipocytes.3 Publications

    Gene expression databases

    BgeeiO35082.
    CleanExiMM_KL.
    GenevestigatoriO35082.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with FGF23 and FGFR1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Wnt1P044262EBI-1570828,EBI-1570911
    Wnt3P175534EBI-1570828,EBI-1570853
    Wnt4P227242EBI-1570828,EBI-1570945
    Wnt5aP227252EBI-1570828,EBI-1570983

    Protein-protein interaction databases

    BioGridi200958. 5 interactions.
    DIPiDIP-39894N.
    IntActiO35082. 5 interactions.
    MINTiMINT-8175062.
    STRINGi10090.ENSMUSP00000077899.

    Structurei

    3D structure databases

    ProteinModelPortaliO35082.
    SMRiO35082. Positions 63-508, 520-955.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 982948ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1004 – 101411CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei983 – 100321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 508450Glycosyl hydrolase-1 1Add
    BLAST
    Regioni517 – 955439Glycosyl hydrolase-1 2Add
    BLAST

    Domaini

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2723.
    GeneTreeiENSGT00550000074452.
    HOGENOMiHOG000060126.
    HOVERGENiHBG081856.
    InParanoidiB2RR78.
    KOiK14756.
    OMAiALSSHWI.
    OrthoDBiEOG7MH0XV.
    TreeFamiTF314803.

    Family and domain databases

    Gene3Di3.20.20.80. 2 hits.
    InterProiIPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR028546. Klotho.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PTHR10353:SF10. PTHR10353:SF10. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 3 hits.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 2 hits.
    PROSITEiPS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O35082-1) [UniParc]FASTAAdd to Basket

    Also known as: Membrane-bound

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLARAPPRRP PRLVLLRLLL LHLLLLALRA RCLSAEPGQG AQTWARFARA     50
    PAPEAAGLLH DTFPDGFLWA VGSAAYQTEG GWRQHGKGAS IWDTFTHHSG 100
    AAPSDSPIVV APSGAPSPPL SSTGDVASDS YNNVYRDTEG LRELGVTHYR 150
    FSISWARVLP NGTAGTPNRE GLRYYRRLLE RLRELGVQPV VTLYHWDLPQ 200
    RLQDTYGGWA NRALADHFRD YAELCFRHFG GQVKYWITID NPYVVAWHGY 250
    ATGRLAPGVR GSSRLGYLVA HNLLLAHAKV WHLYNTSFRP TQGGRVSIAL 300
    SSHWINPRRM TDYNIRECQK SLDFVLGWFA KPIFIDGDYP ESMKNNLSSL 350
    LPDFTESEKR LIRGTADFFA LSFGPTLSFQ LLDPNMKFRQ LESPNLRQLL 400
    SWIDLEYNHP PIFIVENGWF VSGTTKRDDA KYMYYLKKFI METLKAIRLD 450
    GVDVIGYTAW SLMDGFEWHR GYSIRRGLFY VDFLSQDKEL LPKSSALFYQ 500
    KLIEDNGFPP LPENQPLEGT FPCDFAWGVV DNYVQVDTTL SQFTDPNVYL 550
    WDVHHSKRLI KVDGVVAKKR KPYCVDFSAI RPQITLLREM RVTHFRFSLD 600
    WALILPLGNQ TQVNHTVLHF YRCMISELVH ANITPVVALW QPAAPHQGLP 650
    HALAKHGAWE NPHTALAFAD YANLCFKELG HWVNLWITMN EPNTRNMTYR 700
    AGHHLLRAHA LAWHLYDDKF RAAQKGKISI ALQADWIEPA CPFSQNDKEV 750
    AERVLEFDIG WLAEPIFGSG DYPRVMRDWL NQKNNFLLPY FTEDEKKLVR 800
    GSFDFLAVSH YTTILVDWEK EDPMKYNDYL EVQEMTDITW LNSPSQVAVV 850
    PWGLRKVLNW LRFKYGDLPM YVTANGIDDD PHAEQDSLRI YYIKNYVNEA 900
    LKAYVLDDIN LCGYFAYSLS DRSAPKSGFY RYAANQFEPK PSMKHYRKII 950
    DSNGFLGSGT LGRFCPEEYT VCTECGFFQT RKSLLVFISF LVFTFIISLA 1000
    LIFHYSKKGQ RSYK 1014

    Note: Predominates over the secreted form by more than 10 times in all tissues examined.

    Length:1,014
    Mass (Da):116,398
    Last modified:July 27, 2011 - v2
    Checksum:i24BD772A1F81B8EC
    GO
    Isoform 2 (identifier: O35082-2) [UniParc]FASTAAdd to Basket

    Also known as: Secreted

    The sequence of this isoform differs from the canonical sequence as follows:
         537-550: DTTLSQFTDPNVYL → SPLTKPSVGLLLPH
         551-1014: Missing.

    Show »
    Length:550
    Mass (Da):62,348
    Checksum:iE59AF8F24871BDC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti854 – 8541L → V in BAA25308. (PubMed:9537505)Curated
    Sequence conflicti948 – 9481K → R in BAA23381. (PubMed:9363890)Curated
    Sequence conflicti948 – 9481K → R in BAA25308. (PubMed:9537505)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei537 – 55014DTTLS…PNVYL → SPLTKPSVGLLLPH in isoform 2. 1 PublicationVSP_015828Add
    BLAST
    Alternative sequencei551 – 1014464Missing in isoform 2. 1 PublicationVSP_015829Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005141 mRNA. Translation: BAA23381.1.
    AB010088 mRNA. Translation: BAA25307.1.
    AB010091 Genomic DNA. Translation: BAA25308.1.
    AB010091 Genomic DNA. Translation: BAA25309.1.
    BC138258 mRNA. Translation: AAI38259.1.
    BC138259 mRNA. Translation: AAI38260.1.
    CCDSiCCDS19889.1. [O35082-1]
    RefSeqiNP_038851.2. NM_013823.2. [O35082-1]
    UniGeneiMm.6500.

    Genome annotation databases

    EnsembliENSMUST00000078856; ENSMUSP00000077899; ENSMUSG00000058488. [O35082-1]
    GeneIDi16591.
    KEGGimmu:16591.
    UCSCiuc009auk.2. mouse. [O35082-2]
    uc009aul.2. mouse. [O35082-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The thread of life - Issue 65 of December 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005141 mRNA. Translation: BAA23381.1 .
    AB010088 mRNA. Translation: BAA25307.1 .
    AB010091 Genomic DNA. Translation: BAA25308.1 .
    AB010091 Genomic DNA. Translation: BAA25309.1 .
    BC138258 mRNA. Translation: AAI38259.1 .
    BC138259 mRNA. Translation: AAI38260.1 .
    CCDSi CCDS19889.1. [O35082-1 ]
    RefSeqi NP_038851.2. NM_013823.2. [O35082-1 ]
    UniGenei Mm.6500.

    3D structure databases

    ProteinModelPortali O35082.
    SMRi O35082. Positions 63-508, 520-955.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200958. 5 interactions.
    DIPi DIP-39894N.
    IntActi O35082. 5 interactions.
    MINTi MINT-8175062.
    STRINGi 10090.ENSMUSP00000077899.

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    PTM databases

    PhosphoSitei O35082.

    Proteomic databases

    PaxDbi O35082.
    PRIDEi O35082.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078856 ; ENSMUSP00000077899 ; ENSMUSG00000058488 . [O35082-1 ]
    GeneIDi 16591.
    KEGGi mmu:16591.
    UCSCi uc009auk.2. mouse. [O35082-2 ]
    uc009aul.2. mouse. [O35082-1 ]

    Organism-specific databases

    CTDi 9365.
    MGIi MGI:1101771. Kl.

    Phylogenomic databases

    eggNOGi COG2723.
    GeneTreei ENSGT00550000074452.
    HOGENOMi HOG000060126.
    HOVERGENi HBG081856.
    InParanoidi B2RR78.
    KOi K14756.
    OMAi ALSSHWI.
    OrthoDBi EOG7MH0XV.
    TreeFami TF314803.

    Enzyme and pathway databases

    Reactomei REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_202336. FGFR1c and Klotho ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 290141.
    PROi O35082.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35082.
    CleanExi MM_KL.
    Genevestigatori O35082.

    Family and domain databases

    Gene3Di 3.20.20.80. 2 hits.
    InterProi IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR028546. Klotho.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    PTHR10353:SF10. PTHR10353:SF10. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 3 hits.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 2 hits.
    PROSITEi PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
      Tissue: Kidney.
    2. "Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein."
      Shiraki-Iida T., Aizawa H., Matsumura Y., Sekine S., Iida A., Anazawa H., Nagai R., Kuro-o M., Nabeshima Y.
      FEBS Lett. 424:6-10(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    5. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging."
      Utsugi T., Ohno T., Ohyama Y., Uchiyama T., Saito Y., Matsumura Y., Aizawa H., Itoh H., Kurabayashi M., Kawazu S., Tomono S., Oka Y., Suga T., Kuro-o M., Nabeshima Y., Nagai R.
      Metabolism 49:1118-1123(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Upregulation of the klotho gene expression by thyroid hormone and during adipose differentiation in 3T3-L1 adipocytes."
      Mizuno I., Takahashi Y., Okimura Y., Kaji H., Chihara K.
      Life Sci. 68:2917-2923(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, TISSUE SPECIFICITY.
    8. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system."
      Tsujikawa H., Kurotaki Y., Fujimori T., Fukuda K., Nabeshima Y.
      Mol. Endocrinol. 17:2393-2403(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    10. "HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells."
      Narumiya H., Sasaki S., Kuwahara N., Irie H., Kusaba T., Kameyama H., Tamagaki K., Hatta T., Takeda K., Matsubara H.
      Cardiovasc. Res. 64:331-336(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    11. "Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice."
      Li S.-A., Watanabe M., Yamada H., Nagai A., Kinuta M., Takei K.
      Cell Struct. Funct. 29:91-99(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    12. "Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane."
      Imura A., Iwano A., Tohyama O., Tsuji Y., Nozaki K., Hashimoto N., Fujimori T., Nabeshima Y.
      FEBS Lett. 565:143-147(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE, TISSUE SPECIFICITY, SUBUNIT, GLYCOSYLATION, SUBCELLULAR LOCATION.
    13. "Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides."
      Tohyama O., Imura A., Iwano A., Freund J.-N., Henrissat B., Fujimori T., Nabeshima Y.
      J. Biol. Chem. 279:9777-9784(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME ACTIVITY, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
    14. Cited for: FUNCTION, LACK OF ENZYMATIC ACTIVITY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    15. "Klotho converts canonical FGF receptor into a specific receptor for FGF23."
      Urakawa I., Yamazaki Y., Shimada T., Iijima K., Hasegawa H., Okawa K., Fujita T., Fukumoto S., Yamashita T.
      Nature 444:770-774(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FGF23 AND FGFR1.

    Entry informationi

    Entry nameiKLOT_MOUSE
    AccessioniPrimary (citable) accession number: O35082
    Secondary accession number(s): B2RR78, O70175, O70621
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3