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Protein

D-amino-acid oxidase

Gene

Dao

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

Catalytic activityi

A D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52SubstrateBy similarity1
Binding sitei163FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei181FADBy similarity1
Binding sitei216SubstrateBy similarity1
Binding sitei227SubstrateBy similarity1
Binding sitei282SubstrateBy similarity1
Binding sitei312Substrate; via carbonyl oxygenBy similarity1
Binding sitei316FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 17FADBy similarityAdd BLAST15
Nucleotide bindingi36 – 37FADBy similarity2
Nucleotide bindingi43 – 44FADBy similarity2
Nucleotide bindingi48 – 50FADBy similarity3
Nucleotide bindingi311 – 315FADBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.3. 5301.
SABIO-RKiO35078.

Names & Taxonomyi

Protein namesi
Recommended name:
D-amino-acid oxidase (EC:1.4.3.3)
Short name:
DAAO
Short name:
DAMOX
Short name:
DAO
Gene namesi
Name:Dao
Synonyms:Dao1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621138. Dao.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001627651 – 346D-amino-acid oxidaseAdd BLAST346

Proteomic databases

PaxDbiO35078.
PRIDEiO35078.

PTM databases

iPTMnetiO35078.
PhosphoSitePlusiO35078.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250263. 173 interactors.
IntActiO35078. 1 interactor.
MINTiMINT-4582363.
STRINGi10116.ENSRNOP00000000881.

Chemistry databases

BindingDBiO35078.

Structurei

3D structure databases

ProteinModelPortaliO35078.
SMRiO35078.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi344 – 346Microbody targeting signal3

Sequence similaritiesi

Belongs to the DAMOX/DASOX family.Curated

Phylogenomic databases

eggNOGiKOG3923. Eukaryota.
COG0665. LUCA.
HOGENOMiHOG000046303.
HOVERGENiHBG003493.
InParanoidiO35078.
KOiK00273.
PhylomeDBiO35078.
TreeFamiTF313887.

Family and domain databases

InterProiView protein in InterPro
IPR006181. D-amino_acid_oxidase_CS.
IPR023209. DAO.
IPR006076. FAD-dep_OxRdtase.
PANTHERiPTHR11530. PTHR11530. 1 hit.
PfamiView protein in Pfam
PF01266. DAO. 1 hit.
PIRSFiPIRSF000189. D-aa_oxidase. 1 hit.
PROSITEiView protein in PROSITE
PS00677. DAO. 1 hit.

Sequencei

Sequence statusi: Complete.

O35078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAVIGAGV IGLSTALCIH ERYHPAQPLH MKIYADRFTP FTTSDVAAGL
60 70 80 90 100
WQPYLSDPSN PQEAEWNQQT FDHLQSCLHS PNAEKMGLAL ISGYNLFRDE
110 120 130 140 150
VPDPFWKSTV LGFRKLTPSE LDMFPDYSYG WFNTSLLLEG KSYLSWLTER
160 170 180 190 200
LTERGVKFIH RKVASFEEVV RGGVDVIINC TGVWAGALQA DASLQPGRGQ
210 220 230 240 250
IIQVEAPWIK HFILTHDPSL GIYNSPYIIP GSKTVTLGGV FQLGNWSELN
260 270 280 290 300
SVHDHNTIWK SCCQLEPTLK NARIMGELTG FRPVRPQVRL ERERLRFGSS
310 320 330 340
SAEVIHNYGH GGYGLTIHWG CAMEAANLFG KILEEKNLSR MPPSHL
Length:346
Mass (Da):38,820
Last modified:January 1, 1998 - v1
Checksum:i2C4697960137A4FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003400 mRNA. Translation: BAA22840.1.
BC088395 mRNA. Translation: AAH88395.1.
RefSeqiNP_446078.1. NM_053626.1.
UniGeneiRn.81058.

Genome annotation databases

GeneIDi114027.
KEGGirno:114027.
UCSCiRGD:621138. rat.

Similar proteinsi

Entry informationi

Entry nameiOXDA_RAT
AccessioniPrimary (citable) accession number: O35078
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families