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Protein

Down syndrome critical region protein 3 homolog

Gene

Dscr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Down syndrome critical region protein 3 homolog
Alternative name(s):
Down syndrome critical region protein A homolog
Gene namesi
Name:Dscr3
Synonyms:Dcra, Dscra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1206040 Dscr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000730171 – 297Down syndrome critical region protein 3 homologAdd BLAST297

Proteomic databases

EPDiO35075
MaxQBiO35075
PaxDbiO35075
PeptideAtlasiO35075
PRIDEiO35075

PTM databases

iPTMnetiO35075
PhosphoSitePlusiO35075

Expressioni

Gene expression databases

BgeeiENSMUSG00000022898
CleanExiMM_DSCR3
GenevisibleiO35075 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023615

Structurei

3D structure databases

ProteinModelPortaliO35075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VPS26 family.Curated

Phylogenomic databases

eggNOGiKOG2717 Eukaryota
ENOG410XS9N LUCA
GeneTreeiENSGT00390000009324
HOGENOMiHOG000294089
HOVERGENiHBG051411
InParanoidiO35075
OMAiVQHQGVS
OrthoDBiEOG091G0FCI
PhylomeDBiO35075
TreeFamiTF323199

Family and domain databases

Gene3Di2.60.40.640, 2 hits
InterProiView protein in InterPro
IPR014752 Arrestin_C
IPR014756 Ig_E-set
IPR028934 Vps26-related
PANTHERiPTHR12233 PTHR12233, 1 hit
PfamiView protein in Pfam
PF03643 Vps26, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

O35075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTTLDIKIK RANKVYHAGE MLSGVVVISS KDSVQHQGVS LTMEGTVNLQ
60 70 80 90 100
LSAKSVGVFE AFYNSVKPIQ IINSTIDVLK PGKIPSGKTE VPFEFPLLVK
110 120 130 140 150
GSKVLYETYH GVFVNIQYTL RCDMRRSLLA KDLTKTCEFI VHSAPQKGKL
160 170 180 190 200
TPSPVDFTIT PETLQNVKER ASLPKFFIRG HLNSTNCAIT QPLTGELVVE
210 220 230 240 250
HSDAAIRSIE LQLVRVETCG CAEGYARDAT EIQNIQIADG DICRNLSVPL
260 270 280 290
YMVFPRLFTC PTLETTNFKV EFEVNVVVLL HADHLITENF PLKLCRT
Length:297
Mass (Da):32,970
Last modified:January 1, 1998 - v1
Checksum:iD43BD41A613AA3E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001990 mRNA Translation: BAA23270.1
AK077485 mRNA Translation: BAC36824.1
AK077628 mRNA Translation: BAC36911.1
BC003740 mRNA Translation: AAH03740.1
CCDSiCCDS28349.1
PIRiJC5699
RefSeqiNP_031860.1, NM_007834.3
UniGeneiMm.7472

Genome annotation databases

EnsembliENSMUST00000023615; ENSMUSP00000023615; ENSMUSG00000022898
GeneIDi13185
KEGGimmu:13185
UCSCiuc008abe.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDSCR3_MOUSE
AccessioniPrimary (citable) accession number: O35075
Secondary accession number(s): Q542V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health