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Protein

Down syndrome critical region protein 3 homolog

Gene

Dscr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Down syndrome critical region protein 3 homolog
Alternative name(s):
Down syndrome critical region protein A homolog
Gene namesi
Name:Dscr3
Synonyms:Dcra, Dscra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1206040. Dscr3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Down syndrome critical region protein 3 homologPRO_0000073017Add
BLAST

Proteomic databases

EPDiO35075.
MaxQBiO35075.
PaxDbiO35075.
PeptideAtlasiO35075.
PRIDEiO35075.

PTM databases

iPTMnetiO35075.
PhosphoSiteiO35075.

Expressioni

Gene expression databases

BgeeiO35075.
CleanExiMM_DSCR3.
GenevisibleiO35075. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023615.

Structurei

3D structure databases

ProteinModelPortaliO35075.
SMRiO35075. Positions 15-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VPS26 family.Curated

Phylogenomic databases

eggNOGiKOG2717. Eukaryota.
ENOG410XS9N. LUCA.
GeneTreeiENSGT00390000009324.
HOGENOMiHOG000294089.
HOVERGENiHBG051411.
InParanoidiO35075.
OMAiEFEVNVV.
OrthoDBiEOG7C8GHX.
PhylomeDBiO35075.
TreeFamiTF323199.

Family and domain databases

InterProiIPR014756. Ig_E-set.
IPR028934. Vps26-related.
[Graphical view]
PfamiPF03643. Vps26. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O35075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTTLDIKIK RANKVYHAGE MLSGVVVISS KDSVQHQGVS LTMEGTVNLQ
60 70 80 90 100
LSAKSVGVFE AFYNSVKPIQ IINSTIDVLK PGKIPSGKTE VPFEFPLLVK
110 120 130 140 150
GSKVLYETYH GVFVNIQYTL RCDMRRSLLA KDLTKTCEFI VHSAPQKGKL
160 170 180 190 200
TPSPVDFTIT PETLQNVKER ASLPKFFIRG HLNSTNCAIT QPLTGELVVE
210 220 230 240 250
HSDAAIRSIE LQLVRVETCG CAEGYARDAT EIQNIQIADG DICRNLSVPL
260 270 280 290
YMVFPRLFTC PTLETTNFKV EFEVNVVVLL HADHLITENF PLKLCRT
Length:297
Mass (Da):32,970
Last modified:January 1, 1998 - v1
Checksum:iD43BD41A613AA3E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001990 mRNA. Translation: BAA23270.1.
AK077485 mRNA. Translation: BAC36824.1.
AK077628 mRNA. Translation: BAC36911.1.
BC003740 mRNA. Translation: AAH03740.1.
CCDSiCCDS28349.1.
PIRiJC5699.
RefSeqiNP_031860.1. NM_007834.3.
UniGeneiMm.7472.

Genome annotation databases

EnsembliENSMUST00000023615; ENSMUSP00000023615; ENSMUSG00000022898.
GeneIDi13185.
KEGGimmu:13185.
UCSCiuc008abe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001990 mRNA. Translation: BAA23270.1.
AK077485 mRNA. Translation: BAC36824.1.
AK077628 mRNA. Translation: BAC36911.1.
BC003740 mRNA. Translation: AAH03740.1.
CCDSiCCDS28349.1.
PIRiJC5699.
RefSeqiNP_031860.1. NM_007834.3.
UniGeneiMm.7472.

3D structure databases

ProteinModelPortaliO35075.
SMRiO35075. Positions 15-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023615.

PTM databases

iPTMnetiO35075.
PhosphoSiteiO35075.

Proteomic databases

EPDiO35075.
MaxQBiO35075.
PaxDbiO35075.
PeptideAtlasiO35075.
PRIDEiO35075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023615; ENSMUSP00000023615; ENSMUSG00000022898.
GeneIDi13185.
KEGGimmu:13185.
UCSCiuc008abe.2. mouse.

Organism-specific databases

CTDi10311.
MGIiMGI:1206040. Dscr3.

Phylogenomic databases

eggNOGiKOG2717. Eukaryota.
ENOG410XS9N. LUCA.
GeneTreeiENSGT00390000009324.
HOGENOMiHOG000294089.
HOVERGENiHBG051411.
InParanoidiO35075.
OMAiEFEVNVV.
OrthoDBiEOG7C8GHX.
PhylomeDBiO35075.
TreeFamiTF323199.

Miscellaneous databases

PROiO35075.
SOURCEiSearch...

Gene expression databases

BgeeiO35075.
CleanExiMM_DSCR3.
GenevisibleiO35075. MM.

Family and domain databases

InterProiIPR014756. Ig_E-set.
IPR028934. Vps26-related.
[Graphical view]
PfamiPF03643. Vps26. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel human gene from the Down syndrome critical region of chromosome 21q22.2."
    Nakamura A., Hattori M., Sakaki Y.
    J. Biochem. 122:872-877(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiDSCR3_MOUSE
AccessioniPrimary (citable) accession number: O35075
Secondary accession number(s): Q542V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.