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Protein

Down syndrome critical region protein 3 homolog

Gene

Dscr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Down syndrome critical region protein 3 homolog
Alternative name(s):
Down syndrome critical region protein A homolog
Gene namesi
Name:Dscr3
Synonyms:Dcra, Dscra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1206040. Dscr3.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000730171 – 297Down syndrome critical region protein 3 homologAdd BLAST297

Proteomic databases

EPDiO35075.
MaxQBiO35075.
PaxDbiO35075.
PeptideAtlasiO35075.
PRIDEiO35075.

PTM databases

iPTMnetiO35075.
PhosphoSitePlusiO35075.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022898.
CleanExiMM_DSCR3.
GenevisibleiO35075. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023615.

Structurei

3D structure databases

ProteinModelPortaliO35075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VPS26 family.Curated

Phylogenomic databases

eggNOGiKOG2717. Eukaryota.
ENOG410XS9N. LUCA.
GeneTreeiENSGT00390000009324.
HOGENOMiHOG000294089.
HOVERGENiHBG051411.
InParanoidiO35075.
OMAiVQHQGVS.
OrthoDBiEOG091G0FCI.
PhylomeDBiO35075.
TreeFamiTF323199.

Family and domain databases

InterProiView protein in InterPro
IPR014756. Ig_E-set.
IPR028934. Vps26-related.
PANTHERiPTHR12233. PTHR12233. 1 hit.
PfamiView protein in Pfam
PF03643. Vps26. 1 hit.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O35075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTTLDIKIK RANKVYHAGE MLSGVVVISS KDSVQHQGVS LTMEGTVNLQ
60 70 80 90 100
LSAKSVGVFE AFYNSVKPIQ IINSTIDVLK PGKIPSGKTE VPFEFPLLVK
110 120 130 140 150
GSKVLYETYH GVFVNIQYTL RCDMRRSLLA KDLTKTCEFI VHSAPQKGKL
160 170 180 190 200
TPSPVDFTIT PETLQNVKER ASLPKFFIRG HLNSTNCAIT QPLTGELVVE
210 220 230 240 250
HSDAAIRSIE LQLVRVETCG CAEGYARDAT EIQNIQIADG DICRNLSVPL
260 270 280 290
YMVFPRLFTC PTLETTNFKV EFEVNVVVLL HADHLITENF PLKLCRT
Length:297
Mass (Da):32,970
Last modified:January 1, 1998 - v1
Checksum:iD43BD41A613AA3E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001990 mRNA. Translation: BAA23270.1.
AK077485 mRNA. Translation: BAC36824.1.
AK077628 mRNA. Translation: BAC36911.1.
BC003740 mRNA. Translation: AAH03740.1.
CCDSiCCDS28349.1.
PIRiJC5699.
RefSeqiNP_031860.1. NM_007834.3.
UniGeneiMm.7472.

Genome annotation databases

EnsembliENSMUST00000023615; ENSMUSP00000023615; ENSMUSG00000022898.
GeneIDi13185.
KEGGimmu:13185.
UCSCiuc008abe.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDSCR3_MOUSE
AccessioniPrimary (citable) accession number: O35075
Secondary accession number(s): Q542V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families