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Protein

Kinesin-like protein KIF1C

Gene

Kif1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF1C
Gene namesi
Name:Kif1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1098260. Kif1c.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: MGI
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254111 – 1100Kinesin-like protein KIF1CAdd BLAST1100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295PhosphoserineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei674PhosphoserineCombined sources1
Modified residuei676PhosphoserineCombined sources1
Modified residuei914PhosphoserineBy similarity1
Modified residuei1031PhosphoserineBy similarity1
Modified residuei1039Omega-N-methylarginineCombined sources1
Modified residuei1080PhosphothreonineBy similarity1
Modified residuei1089PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO35071.
MaxQBiO35071.
PaxDbiO35071.
PeptideAtlasiO35071.
PRIDEiO35071.

PTM databases

iPTMnetiO35071.
PhosphoSitePlusiO35071.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020821.
CleanExiMM_KIF1C.
ExpressionAtlasiO35071. baseline and differential.
GenevisibleiO35071. MM.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi200937. 20 interactors.
IntActiO35071. 20 interactors.
STRINGi10090.ENSMUSP00000092075.

Structurei

3D structure databases

ProteinModelPortaliO35071.
SMRiO35071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 348Kinesin motorPROSITE-ProRule annotationAdd BLAST344
Domaini523 – 590FHAAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili359 – 381Sequence analysisAdd BLAST23
Coiled coili438 – 479Sequence analysisAdd BLAST42
Coiled coili634 – 671Sequence analysisAdd BLAST38
Coiled coili827 – 871Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi964 – 1082Pro-richAdd BLAST119

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation
Contains 1 FHA domain.Curated
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOVERGENiHBG057158.
InParanoidiO35071.
KOiK10392.
PhylomeDBiO35071.
TreeFamiTF105221.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF
60 70 80 90 100
TFDYSYWSHT SVEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGR QEPGQQGIVP QLCEDLFSRV NVNQSAQLSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KSRGSLRVRE HPILGPYVQD LSKLAVTSYA DIADLMDCGN
210 220 230 240 250
KARTVAATNM NETSSRSHAV FTIVFTQRSH DQLTGLDSEK VSKISLVDLA
260 270 280 290 300
GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADLQS KKRKSDFIPY
310 320 330 340 350
RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC
360 370 380 390 400
NAVINEDPNA RLIRELQEEV ARLRDLLMAQ GLSASALGGL KVEEGSPGGV
410 420 430 440 450
LPPASSPPAP ASPSSPPPHN GELEPSFSPS AEPQIGPEEA MERLQETEKI
460 470 480 490 500
IAELNETWEE KLRKTEALRM EREALLAEMG VAVREDGGTV GVFSPKKTPH
510 520 530 540 550
LVNLNEDPLM SECLLYHIKD GVTRVGQVDV DIKLTGQFIR EQHCLFRSIP
560 570 580 590 600
QPDGEVMVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP
610 620 630 640 650
EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL
660 670 680 690 700
ENQYRKEKEE ADLLLEQQRL YADSDSGEDS DKRSCEESWR LISSLREQLP
710 720 730 740 750
PTTVQNIVKR CGLPSSGKRR APRRVYQIPQ RRRLQGKDPR WATMADLKMQ
760 770 780 790 800
AVKEICYEVA LADFRHGRAE IEALAALKMR ELCRTYGKPE GPGDAWRAVA
810 820 830 840 850
RDVWDTVGEE EGCGGGGGGS EEGARGAEVE DLRAHIDKLT GILQEVKLQN
860 870 880 890 900
SSKDRELQAL RDRMLRMERV IPLTQDLEDD NDESGLVTWA PPEGPEAVEE
910 920 930 940 950
TVPNDHSPAV RPTSPPLSSW ERVSRLMEED PAFRRGRLRW LKQEQLRLQG
960 970 980 990 1000
LQGAGGRGGG LRRPPARFVP PHDCKLRFPF KSNPQHRESW PGMGSGEAPA
1010 1020 1030 1040 1050
PQPPEEVTVP PAPPNRRPPS PRRPHRSRRN SLDGGSRSRG GGSTQPEPQH
1060 1070 1080 1090 1100
LRPQKHNGYP QQPQPSPAQR PGPRYPPYTT PPRMRRQRSA PDLKESGAAV
Length:1,100
Mass (Da):122,434
Last modified:October 11, 2005 - v2
Checksum:iE92CFFECE6D0F0DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596117 Genomic DNA. Translation: CAI25184.1.
AB001456 mRNA. Translation: BAA22398.1.
CCDSiCCDS24965.1.
RefSeqiNP_694743.2. NM_153103.2.
XP_006532383.1. XM_006532320.3.
XP_006532384.1. XM_006532321.3.
XP_006532385.1. XM_006532322.3.
UniGeneiMm.99996.

Genome annotation databases

EnsembliENSMUST00000094499; ENSMUSP00000092075; ENSMUSG00000020821.
ENSMUST00000102554; ENSMUSP00000099614; ENSMUSG00000020821.
ENSMUST00000137119; ENSMUSP00000123242; ENSMUSG00000020821.
GeneIDi16562.
KEGGimmu:16562.
UCSCiuc007jwl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596117 Genomic DNA. Translation: CAI25184.1.
AB001456 mRNA. Translation: BAA22398.1.
CCDSiCCDS24965.1.
RefSeqiNP_694743.2. NM_153103.2.
XP_006532383.1. XM_006532320.3.
XP_006532384.1. XM_006532321.3.
XP_006532385.1. XM_006532322.3.
UniGeneiMm.99996.

3D structure databases

ProteinModelPortaliO35071.
SMRiO35071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200937. 20 interactors.
IntActiO35071. 20 interactors.
STRINGi10090.ENSMUSP00000092075.

PTM databases

iPTMnetiO35071.
PhosphoSitePlusiO35071.

Proteomic databases

EPDiO35071.
MaxQBiO35071.
PaxDbiO35071.
PeptideAtlasiO35071.
PRIDEiO35071.

Protocols and materials databases

DNASUi16562.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094499; ENSMUSP00000092075; ENSMUSG00000020821.
ENSMUST00000102554; ENSMUSP00000099614; ENSMUSG00000020821.
ENSMUST00000137119; ENSMUSP00000123242; ENSMUSG00000020821.
GeneIDi16562.
KEGGimmu:16562.
UCSCiuc007jwl.1. mouse.

Organism-specific databases

CTDi10749.
MGIiMGI:1098260. Kif1c.

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOVERGENiHBG057158.
InParanoidiO35071.
KOiK10392.
PhylomeDBiO35071.
TreeFamiTF105221.

Miscellaneous databases

ChiTaRSiKif1c. mouse.
PROiO35071.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020821.
CleanExiMM_KIF1C.
ExpressionAtlasiO35071. baseline and differential.
GenevisibleiO35071. MM.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF1C_MOUSE
AccessioniPrimary (citable) accession number: O35071
Secondary accession number(s): Q5SX62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.