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O35066 (KIF3C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF3C
Gene names
Name:Kif3c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length796 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Microtubule-based anterograde translocator for membranous organelles By similarity.

Subunit structure

Heterodimer of KIF3A and KIF3C By similarity.

Subcellular location

Cytoplasm › cytoskeleton Probable.

Sequence similarities

Belongs to the kinesin-like protein family. Kinesin II subfamily.

Contains 1 kinesin-motor domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   DomainCoiled coil
   LigandATP-binding
Nucleotide-binding
   Molecular functionMotor protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmicrotubule-based movement

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule associated complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 796796Kinesin-like protein KIF3C
PRO_0000125398

Regions

Domain1 – 377377Kinesin-motor
Nucleotide binding97 – 1048ATP By similarity
Region633 – 793161Globular Potential
Coiled coil378 – 632255 Potential
Compositional bias440 – 4434Poly-Asn

Experimental info

Sequence conflict931V → I in BAA22393. Ref.4
Sequence conflict5641L → V in AAC39965. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35066 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 5CC5A5EB12958166

FASTA79689,973
        10         20         30         40         50         60 
MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA PGELPKTFTF 

        70         80         90        100        110        120 
DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG TGKTYTMQGT WVEPELRGVI 

       130        140        150        160        170        180 
PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ EEIRDLLSKE PGKRLELKEN PETGVYIKDL 

       190        200        210        220        230        240 
SSFVTKNVKE IEHVMNLGNQ ARAVGSTHMN EVSSRSHAIF VITVECSERG SDGQDHIRVG 

       250        260        270        280        290        300 
KLNLVDLAGS ERQNKAGPNA AGGPATQPTA GGGSGSGSAS GSASSGERPK EASKINLSLS 

       310        320        330        340        350        360 
ALGNVIAALA GNRSTHIPYR DSKLTRLLQD SLGGNAKTIM VATLGPASHS YDESLSTLRF 

       370        380        390        400        410        420 
ANRAKNIKNK PRVNEDPKDT LLREFQEEIA RLKAQLEKKG MLGKRPRRKS SRRKKAVSAP 

       430        440        450        460        470        480 
AGYPEGSVIE AWVAEEEDDN NNNHHPPQPI LEAALEKNME NYLQDQKERL EEEKAAIQDD 

       490        500        510        520        530        540 
RSLVSEEKQK LLEEKEKMLE DLRREQQATE LLAAKYKAME SKLLIGGRNI MDHTNEQQKM 

       550        560        570        580        590        600 
LELKRQEIAE QKRREREMQQ EMLLRDEETM ELRGTYSSLQ QEVEVKTKKL KKLYAKLQAV 

       610        620        630        640        650        660 
KAEIQDQHEE YIRVRQDLEE AQNEQTRELK LKYLIIENFI PPEEKNKIMN RLFLDCEEEQ 

       670        680        690        700        710        720 
WRFQPLVPAG VNNSQMKKRP TSAVGYKRPI SQYARVAMAM GSHPRYRAEN IMFLELDVSP 

       730        740        750        760        770        780 
PAIFEMEFSH DQEQDPRVLH MERLMRLDSF LERPSTTKVR KSRSWCQSPQ RMPPPSTAHA 

       790 
SMTSVPLHPA TVVDHD

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the KIF3C neural kinesin-like motor from mouse."
Yang Z., Goldstein L.S.B.
Mol. Biol. Cell 9:249-261(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 93-157.
Strain: ICR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF013116 mRNA. Translation: AAC39965.1.
AK147572 mRNA. Translation: BAE28002.1.
CH466623 Genomic DNA. Translation: EDL01397.1.
BC127063 mRNA. Translation: AAI27064.1.
AB001433 mRNA. Translation: BAA22393.1.
IPIIPI00126443.
RefSeqNP_032471.2. NM_008445.2.
UniGeneMm.415417.
Mm.7688.

3D structure databases

ProteinModelPortalO35066.
SMRO35066. Positions 7-374.
ModBaseSearch...

PTM databases

PhosphoSiteO35066.

Proteomic databases

PaxDbO35066.
PRIDEO35066.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020999; ENSMUSP00000020999; ENSMUSG00000020668.
GeneID16570.
KEGGmmu:16570.

Organism-specific databases

CTD3797.
MGIMGI:107979. Kif3c.

Phylogenomic databases

eggNOGCOG5059.
GeneTreeENSGT00690000101932.
HOVERGENHBG052255.
InParanoidQ3UH55.
KOK10394.
OMAMLLRDEE.
OrthoDBEOG4MCWZT.

Enzyme and pathway databases

ReactomeREACT_89750. Hemostasis.

Gene expression databases

ArrayExpressO35066.
BgeeO35066.
CleanExMM_KIF3C.
GenevestigatorO35066.
GermOnlineENSMUSG00000020668. Mus musculus.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
[Graphical view]
PfamPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290081.
SOURCESearch...

Entry information

Entry nameKIF3C_MOUSE
AccessionPrimary (citable) accession number: O35066
Secondary accession number(s): O35229, Q3UH55
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: April 3, 2013
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents