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Protein

Kinesin-like protein KIF3C

Gene

Kif3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • microtubule-based movement Source: Reactome
  • organelle transport along microtubule Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-5620924. Intraflagellar transport.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-MMU-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3C
Gene namesi
Name:Kif3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:107979. Kif3c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253981 – 796Kinesin-like protein KIF3CAdd BLAST796

Proteomic databases

EPDiO35066.
MaxQBiO35066.
PaxDbiO35066.
PeptideAtlasiO35066.
PRIDEiO35066.

PTM databases

iPTMnetiO35066.
PhosphoSitePlusiO35066.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020668.
CleanExiMM_KIF3C.
GenevisibleiO35066. MM.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3C.By similarity

Protein-protein interaction databases

BioGridi200943. 12 interactors.
IntActiO35066. 13 interactors.
STRINGi10090.ENSMUSP00000020999.

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi377 – 402Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JVMX-ray1.57A/B374-402[»]
ProteinModelPortaliO35066.
SMRiO35066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 367Kinesin motorPROSITE-ProRule annotationAdd BLAST358

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni633 – 793GlobularSequence analysisAdd BLAST161

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili378 – 632Sequence analysisAdd BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi440 – 443Poly-Asn4

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOVERGENiHBG052255.
InParanoidiO35066.
KOiK20197.
OMAiWVAEEED.
OrthoDBiEOG091G03RO.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA
60 70 80 90 100
PGELPKTFTF DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG
110 120 130 140 150
TGKTYTMQGT WVEPELRGVI PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ
160 170 180 190 200
EEIRDLLSKE PGKRLELKEN PETGVYIKDL SSFVTKNVKE IEHVMNLGNQ
210 220 230 240 250
ARAVGSTHMN EVSSRSHAIF VITVECSERG SDGQDHIRVG KLNLVDLAGS
260 270 280 290 300
ERQNKAGPNA AGGPATQPTA GGGSGSGSAS GSASSGERPK EASKINLSLS
310 320 330 340 350
ALGNVIAALA GNRSTHIPYR DSKLTRLLQD SLGGNAKTIM VATLGPASHS
360 370 380 390 400
YDESLSTLRF ANRAKNIKNK PRVNEDPKDT LLREFQEEIA RLKAQLEKKG
410 420 430 440 450
MLGKRPRRKS SRRKKAVSAP AGYPEGSVIE AWVAEEEDDN NNNHHPPQPI
460 470 480 490 500
LEAALEKNME NYLQDQKERL EEEKAAIQDD RSLVSEEKQK LLEEKEKMLE
510 520 530 540 550
DLRREQQATE LLAAKYKAME SKLLIGGRNI MDHTNEQQKM LELKRQEIAE
560 570 580 590 600
QKRREREMQQ EMLLRDEETM ELRGTYSSLQ QEVEVKTKKL KKLYAKLQAV
610 620 630 640 650
KAEIQDQHEE YIRVRQDLEE AQNEQTRELK LKYLIIENFI PPEEKNKIMN
660 670 680 690 700
RLFLDCEEEQ WRFQPLVPAG VNNSQMKKRP TSAVGYKRPI SQYARVAMAM
710 720 730 740 750
GSHPRYRAEN IMFLELDVSP PAIFEMEFSH DQEQDPRVLH MERLMRLDSF
760 770 780 790
LERPSTTKVR KSRSWCQSPQ RMPPPSTAHA SMTSVPLHPA TVVDHD
Length:796
Mass (Da):89,973
Last modified:July 27, 2011 - v3
Checksum:i5CC5A5EB12958166
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93V → I in BAA22393 (PubMed:15489334).Curated1
Sequence conflicti564L → V in AAC39965 (PubMed:9450952).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013116 mRNA. Translation: AAC39965.1.
AK147572 mRNA. Translation: BAE28002.1.
CH466623 Genomic DNA. Translation: EDL01397.1.
BC127063 mRNA. Translation: AAI27064.1.
AB001433 mRNA. Translation: BAA22393.1.
CCDSiCCDS25783.1.
RefSeqiNP_032471.2. NM_008445.2.
UniGeneiMm.415417.
Mm.472456.
Mm.7688.

Genome annotation databases

EnsembliENSMUST00000020999; ENSMUSP00000020999; ENSMUSG00000020668.
GeneIDi16570.
KEGGimmu:16570.
UCSCiuc007mwm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013116 mRNA. Translation: AAC39965.1.
AK147572 mRNA. Translation: BAE28002.1.
CH466623 Genomic DNA. Translation: EDL01397.1.
BC127063 mRNA. Translation: AAI27064.1.
AB001433 mRNA. Translation: BAA22393.1.
CCDSiCCDS25783.1.
RefSeqiNP_032471.2. NM_008445.2.
UniGeneiMm.415417.
Mm.472456.
Mm.7688.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JVMX-ray1.57A/B374-402[»]
ProteinModelPortaliO35066.
SMRiO35066.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200943. 12 interactors.
IntActiO35066. 13 interactors.
STRINGi10090.ENSMUSP00000020999.

PTM databases

iPTMnetiO35066.
PhosphoSitePlusiO35066.

Proteomic databases

EPDiO35066.
MaxQBiO35066.
PaxDbiO35066.
PeptideAtlasiO35066.
PRIDEiO35066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020999; ENSMUSP00000020999; ENSMUSG00000020668.
GeneIDi16570.
KEGGimmu:16570.
UCSCiuc007mwm.1. mouse.

Organism-specific databases

CTDi3797.
MGIiMGI:107979. Kif3c.

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOVERGENiHBG052255.
InParanoidiO35066.
KOiK20197.
OMAiWVAEEED.
OrthoDBiEOG091G03RO.
TreeFamiTF105223.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-5620924. Intraflagellar transport.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-MMU-983189. Kinesins.

Miscellaneous databases

PROiO35066.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020668.
CleanExiMM_KIF3C.
GenevisibleiO35066. MM.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF3C_MOUSE
AccessioniPrimary (citable) accession number: O35066
Secondary accession number(s): O35229, Q3UH55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.