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O35066

- KIF3C_MOUSE

UniProt

O35066 - KIF3C_MOUSE

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Protein

Kinesin-like protein KIF3C

Gene
Kif3c
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: InterPro
  3. protein binding Source: MGI

GO - Biological processi

  1. organelle transport along microtubule Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3C
Gene namesi
Name:Kif3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:107979. Kif3c.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. kinesin complex Source: InterPro
  3. microtubule Source: UniProtKB-KW
  4. neuronal cell body Source: MGI
  5. neuronal ribonucleoprotein granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Kinesin-like protein KIF3CPRO_0000125398Add
BLAST

Proteomic databases

PaxDbiO35066.
PRIDEiO35066.

PTM databases

PhosphoSiteiO35066.

Expressioni

Gene expression databases

BgeeiO35066.
CleanExiMM_KIF3C.
GenevestigatoriO35066.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3C By similarity.

Structurei

3D structure databases

ProteinModelPortaliO35066.
SMRiO35066. Positions 7-374.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 367358Kinesin motorAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni633 – 793161Globular Reviewed predictionAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili378 – 632255 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi440 – 4434Poly-Asn

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00750000117465.
HOVERGENiHBG052255.
InParanoidiQ3UH55.
KOiK10394.
OMAiWVAEEED.
OrthoDBiEOG7WX086.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35066-1 [UniParc]FASTAAdd to Basket

« Hide

MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA    50
PGELPKTFTF DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG 100
TGKTYTMQGT WVEPELRGVI PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ 150
EEIRDLLSKE PGKRLELKEN PETGVYIKDL SSFVTKNVKE IEHVMNLGNQ 200
ARAVGSTHMN EVSSRSHAIF VITVECSERG SDGQDHIRVG KLNLVDLAGS 250
ERQNKAGPNA AGGPATQPTA GGGSGSGSAS GSASSGERPK EASKINLSLS 300
ALGNVIAALA GNRSTHIPYR DSKLTRLLQD SLGGNAKTIM VATLGPASHS 350
YDESLSTLRF ANRAKNIKNK PRVNEDPKDT LLREFQEEIA RLKAQLEKKG 400
MLGKRPRRKS SRRKKAVSAP AGYPEGSVIE AWVAEEEDDN NNNHHPPQPI 450
LEAALEKNME NYLQDQKERL EEEKAAIQDD RSLVSEEKQK LLEEKEKMLE 500
DLRREQQATE LLAAKYKAME SKLLIGGRNI MDHTNEQQKM LELKRQEIAE 550
QKRREREMQQ EMLLRDEETM ELRGTYSSLQ QEVEVKTKKL KKLYAKLQAV 600
KAEIQDQHEE YIRVRQDLEE AQNEQTRELK LKYLIIENFI PPEEKNKIMN 650
RLFLDCEEEQ WRFQPLVPAG VNNSQMKKRP TSAVGYKRPI SQYARVAMAM 700
GSHPRYRAEN IMFLELDVSP PAIFEMEFSH DQEQDPRVLH MERLMRLDSF 750
LERPSTTKVR KSRSWCQSPQ RMPPPSTAHA SMTSVPLHPA TVVDHD 796
Length:796
Mass (Da):89,973
Last modified:July 27, 2011 - v3
Checksum:i5CC5A5EB12958166
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931V → I in BAA22393. 1 Publication
Sequence conflicti564 – 5641L → V in AAC39965. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013116 mRNA. Translation: AAC39965.1.
AK147572 mRNA. Translation: BAE28002.1.
CH466623 Genomic DNA. Translation: EDL01397.1.
BC127063 mRNA. Translation: AAI27064.1.
AB001433 mRNA. Translation: BAA22393.1.
CCDSiCCDS25783.1.
RefSeqiNP_032471.2. NM_008445.2.
UniGeneiMm.415417.
Mm.472456.
Mm.7688.

Genome annotation databases

EnsembliENSMUST00000020999; ENSMUSP00000020999; ENSMUSG00000020668.
GeneIDi16570.
KEGGimmu:16570.
UCSCiuc007mwm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013116 mRNA. Translation: AAC39965.1 .
AK147572 mRNA. Translation: BAE28002.1 .
CH466623 Genomic DNA. Translation: EDL01397.1 .
BC127063 mRNA. Translation: AAI27064.1 .
AB001433 mRNA. Translation: BAA22393.1 .
CCDSi CCDS25783.1.
RefSeqi NP_032471.2. NM_008445.2.
UniGenei Mm.415417.
Mm.472456.
Mm.7688.

3D structure databases

ProteinModelPortali O35066.
SMRi O35066. Positions 7-374.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O35066.

Proteomic databases

PaxDbi O35066.
PRIDEi O35066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020999 ; ENSMUSP00000020999 ; ENSMUSG00000020668 .
GeneIDi 16570.
KEGGi mmu:16570.
UCSCi uc007mwm.1. mouse.

Organism-specific databases

CTDi 3797.
MGIi MGI:107979. Kif3c.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00750000117465.
HOVERGENi HBG052255.
InParanoidi Q3UH55.
KOi K10394.
OMAi WVAEEED.
OrthoDBi EOG7WX086.
TreeFami TF105223.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Miscellaneous databases

NextBioi 290081.
PROi O35066.
SOURCEi Search...

Gene expression databases

Bgeei O35066.
CleanExi MM_KIF3C.
Genevestigatori O35066.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 2 hits.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the KIF3C neural kinesin-like motor from mouse."
    Yang Z., Goldstein L.S.B.
    Mol. Biol. Cell 9:249-261(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
    Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
    Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 93-157.
    Strain: ICR.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiKIF3C_MOUSE
AccessioniPrimary (citable) accession number: O35066
Secondary accession number(s): O35229, Q3UH55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi