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Protein

Kinesin-like protein KIF3C

Gene

Kif3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: GO_Central
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: GO_Central

GO - Biological processi

  1. metabolic process Source: GOC
  2. organelle transport along microtubule Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_316383. MHC class II antigen presentation.
REACT_341960. Intraflagellar transport.
REACT_342780. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3C
Gene namesi
Name:Kif3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:107979. Kif3c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. kinesin complex Source: GO_Central
  3. microtubule Source: UniProtKB-KW
  4. neuronal cell body Source: MGI
  5. neuronal ribonucleoprotein granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Kinesin-like protein KIF3CPRO_0000125398Add
BLAST

Proteomic databases

MaxQBiO35066.
PaxDbiO35066.
PRIDEiO35066.

PTM databases

PhosphoSiteiO35066.

Expressioni

Gene expression databases

BgeeiO35066.
CleanExiMM_KIF3C.
ExpressionAtlasiO35066. baseline and differential.
GenevestigatoriO35066.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3C.By similarity

Structurei

3D structure databases

ProteinModelPortaliO35066.
SMRiO35066. Positions 7-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 367358Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni633 – 793161GlobularSequence AnalysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili378 – 632255Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi440 – 4434Poly-Asn

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOVERGENiHBG052255.
InParanoidiO35066.
KOiK10394.
OMAiNMENYLQ.
OrthoDBiEOG7WX086.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA
60 70 80 90 100
PGELPKTFTF DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG
110 120 130 140 150
TGKTYTMQGT WVEPELRGVI PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ
160 170 180 190 200
EEIRDLLSKE PGKRLELKEN PETGVYIKDL SSFVTKNVKE IEHVMNLGNQ
210 220 230 240 250
ARAVGSTHMN EVSSRSHAIF VITVECSERG SDGQDHIRVG KLNLVDLAGS
260 270 280 290 300
ERQNKAGPNA AGGPATQPTA GGGSGSGSAS GSASSGERPK EASKINLSLS
310 320 330 340 350
ALGNVIAALA GNRSTHIPYR DSKLTRLLQD SLGGNAKTIM VATLGPASHS
360 370 380 390 400
YDESLSTLRF ANRAKNIKNK PRVNEDPKDT LLREFQEEIA RLKAQLEKKG
410 420 430 440 450
MLGKRPRRKS SRRKKAVSAP AGYPEGSVIE AWVAEEEDDN NNNHHPPQPI
460 470 480 490 500
LEAALEKNME NYLQDQKERL EEEKAAIQDD RSLVSEEKQK LLEEKEKMLE
510 520 530 540 550
DLRREQQATE LLAAKYKAME SKLLIGGRNI MDHTNEQQKM LELKRQEIAE
560 570 580 590 600
QKRREREMQQ EMLLRDEETM ELRGTYSSLQ QEVEVKTKKL KKLYAKLQAV
610 620 630 640 650
KAEIQDQHEE YIRVRQDLEE AQNEQTRELK LKYLIIENFI PPEEKNKIMN
660 670 680 690 700
RLFLDCEEEQ WRFQPLVPAG VNNSQMKKRP TSAVGYKRPI SQYARVAMAM
710 720 730 740 750
GSHPRYRAEN IMFLELDVSP PAIFEMEFSH DQEQDPRVLH MERLMRLDSF
760 770 780 790
LERPSTTKVR KSRSWCQSPQ RMPPPSTAHA SMTSVPLHPA TVVDHD
Length:796
Mass (Da):89,973
Last modified:July 27, 2011 - v3
Checksum:i5CC5A5EB12958166
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931V → I in BAA22393 (PubMed:15489334).Curated
Sequence conflicti564 – 5641L → V in AAC39965 (PubMed:9450952).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013116 mRNA. Translation: AAC39965.1.
AK147572 mRNA. Translation: BAE28002.1.
CH466623 Genomic DNA. Translation: EDL01397.1.
BC127063 mRNA. Translation: AAI27064.1.
AB001433 mRNA. Translation: BAA22393.1.
CCDSiCCDS25783.1.
RefSeqiNP_032471.2. NM_008445.2.
UniGeneiMm.415417.
Mm.472456.
Mm.7688.

Genome annotation databases

EnsembliENSMUST00000020999; ENSMUSP00000020999; ENSMUSG00000020668.
GeneIDi16570.
KEGGimmu:16570.
UCSCiuc007mwm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013116 mRNA. Translation: AAC39965.1.
AK147572 mRNA. Translation: BAE28002.1.
CH466623 Genomic DNA. Translation: EDL01397.1.
BC127063 mRNA. Translation: AAI27064.1.
AB001433 mRNA. Translation: BAA22393.1.
CCDSiCCDS25783.1.
RefSeqiNP_032471.2. NM_008445.2.
UniGeneiMm.415417.
Mm.472456.
Mm.7688.

3D structure databases

ProteinModelPortaliO35066.
SMRiO35066. Positions 7-374.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO35066.

Proteomic databases

MaxQBiO35066.
PaxDbiO35066.
PRIDEiO35066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020999; ENSMUSP00000020999; ENSMUSG00000020668.
GeneIDi16570.
KEGGimmu:16570.
UCSCiuc007mwm.1. mouse.

Organism-specific databases

CTDi3797.
MGIiMGI:107979. Kif3c.

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOVERGENiHBG052255.
InParanoidiO35066.
KOiK10394.
OMAiNMENYLQ.
OrthoDBiEOG7WX086.
TreeFamiTF105223.

Enzyme and pathway databases

ReactomeiREACT_316383. MHC class II antigen presentation.
REACT_341960. Intraflagellar transport.
REACT_342780. Kinesins.

Miscellaneous databases

NextBioi290081.
PROiO35066.
SOURCEiSearch...

Gene expression databases

BgeeiO35066.
CleanExiMM_KIF3C.
ExpressionAtlasiO35066. baseline and differential.
GenevestigatoriO35066.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the KIF3C neural kinesin-like motor from mouse."
    Yang Z., Goldstein L.S.B.
    Mol. Biol. Cell 9:249-261(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
    Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
    Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 93-157.
    Strain: ICR.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiKIF3C_MOUSE
AccessioniPrimary (citable) accession number: O35066
Secondary accession number(s): O35229, Q3UH55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.