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Protein

Transcriptional repressor CcpN

Gene

ccpN

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription repressor that binds to the promoter of gapB and pckA genes, preventing their expression. Acts as a regulator for catabolite repression of gluconeogenic genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi23 – 42H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • carbon catabolite repression of transcription Source: CACAO
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciBSUB:BSU25250-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor CcpN
Alternative name(s):
Catabolite control protein N
Control catabolite protein of gluconeogenesis
Gene namesi
Name:ccpN
Synonyms:yqzB
Ordered Locus Names:BSU25250
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Relieves catabolite repression of gapB and pckA transcription. Disruption is epistatic over a yqfL deletion.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003600441 – 212Transcriptional repressor CcpNAdd BLAST212

Proteomic databases

PaxDbiO34994
PRIDEiO34994

Expressioni

Inductioni

Constitutively expressed.1 Publication

Interactioni

Protein-protein interaction databases

IntActiO34994, 2 interactors
STRINGi224308.Bsubs1_010100013806

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 75Combined sources7
Helixi80 – 82Combined sources3
Beta strandi89 – 91Combined sources3
Helixi96 – 106Combined sources11
Beta strandi109 – 114Combined sources6
Beta strandi120 – 125Combined sources6
Helixi126 – 133Combined sources8
Turni139 – 141Combined sources3
Helixi144 – 146Combined sources3
Beta strandi148 – 150Combined sources3
Helixi163 – 173Combined sources11
Beta strandi176 – 183Combined sources8
Beta strandi185 – 195Combined sources11
Helixi196 – 207Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FV6X-ray1.95A/B63-212[»]
3FWRX-ray2.45A/B63-212[»]
3FWSX-ray2.03A/B63-212[»]
ProteinModelPortaliO34994
SMRiO34994
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO34994

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 70HTH deoR-typeAdd BLAST65
Domaini83 – 139CBS 1PROSITE-ProRule annotationAdd BLAST57
Domaini148 – 211CBS 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0517 LUCA
HOGENOMiHOG000039552
InParanoidiO34994
OMAiSVIMTRM
PhylomeDBiO34994

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000644 CBS_dom
IPR013196 HTH_11
IPR016842 UCP026546_HTH-CBS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00571 CBS, 2 hits
PF08279 HTH_11, 1 hit
PIRSFiPIRSF026546 UCP026546_CBS_YqzB, 1 hit
SMARTiView protein in SMART
SM00116 CBS, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits

Sequencei

Sequence statusi: Complete.

O34994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIELNKRQ EHILQIVKEN GPITGEHIAE KLNLTRATLR PDLAILTMSG
60 70 80 90 100
FLEARPRVGY FYTGKTGTQL LADKLKKLQV KDFQSIPVVI HENVSVYDAI
110 120 130 140 150
CTMFLEDVGT LFVVDRDAVL VGVLSRKDLL RASIGQQELT SVPVHIIMTR
160 170 180 190 200
MPNITVCRRE DYVMDIAKHL IEKQIDALPV IKDTDKGFEV IGRVTKTNMT
210
KILVSLSENE IL
Length:212
Mass (Da):23,870
Last modified:January 1, 1998 - v1
Checksum:iE001269F2BB93F9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB14454.1
PIRiA69969
RefSeqiNP_390403.1, NC_000964.3
WP_003237058.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14454; CAB14454; BSU25250
GeneIDi937886
KEGGibsu:BSU25250
PATRICifig|224308.179.peg.2744

Similar proteinsi

Entry informationi

Entry nameiCCPN_BACSU
AccessioniPrimary (citable) accession number: O34994
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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