Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional repressor CcpN

Gene

ccpN

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor that binds to the promoter of gapB and pckA genes, preventing their expression. Acts as a regulator for catabolite repression of gluconeogenic genes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi23 – 4220H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • carbon catabolite repression of transcription Source: CACAO
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU25250-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor CcpN
Alternative name(s):
Catabolite control protein N
Control catabolite protein of gluconeogenesis
Gene namesi
Name:ccpN
Synonyms:yqzB
Ordered Locus Names:BSU25250
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Relieves catabolite repression of gapB and pckA transcription. Disruption is epistatic over a yqfL deletion.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Transcriptional repressor CcpNPRO_0000360044Add
BLAST

Proteomic databases

PaxDbiO34994.

Expressioni

Inductioni

Constitutively expressed.1 Publication

Interactioni

Protein-protein interaction databases

IntActiO34994. 2 interactions.
STRINGi224308.Bsubs1_010100013806.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi69 – 757Combined sources
Helixi80 – 823Combined sources
Beta strandi89 – 913Combined sources
Helixi96 – 10611Combined sources
Beta strandi109 – 1146Combined sources
Beta strandi120 – 1256Combined sources
Helixi126 – 1338Combined sources
Turni139 – 1413Combined sources
Helixi144 – 1463Combined sources
Beta strandi148 – 1503Combined sources
Helixi163 – 17311Combined sources
Beta strandi176 – 1838Combined sources
Beta strandi185 – 19511Combined sources
Helixi196 – 20712Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FV6X-ray1.95A/B63-212[»]
3FWRX-ray2.45A/B63-212[»]
3FWSX-ray2.03A/B63-212[»]
ProteinModelPortaliO34994.
SMRiO34994. Positions 5-57, 64-209.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO34994.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7065HTH deoR-typeAdd
BLAST
Domaini83 – 13957CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini148 – 21164CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0517. LUCA.
HOGENOMiHOG000039552.
InParanoidiO34994.
OMAiSVIMTRM.
PhylomeDBiO34994.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR013196. HTH_11.
IPR016842. UCP026546_HTH-CBS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF08279. HTH_11. 1 hit.
[Graphical view]
PIRSFiPIRSF026546. UCP026546_CBS_YqzB. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIELNKRQ EHILQIVKEN GPITGEHIAE KLNLTRATLR PDLAILTMSG
60 70 80 90 100
FLEARPRVGY FYTGKTGTQL LADKLKKLQV KDFQSIPVVI HENVSVYDAI
110 120 130 140 150
CTMFLEDVGT LFVVDRDAVL VGVLSRKDLL RASIGQQELT SVPVHIIMTR
160 170 180 190 200
MPNITVCRRE DYVMDIAKHL IEKQIDALPV IKDTDKGFEV IGRVTKTNMT
210
KILVSLSENE IL
Length:212
Mass (Da):23,870
Last modified:January 1, 1998 - v1
Checksum:iE001269F2BB93F9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB14454.1.
PIRiA69969.
RefSeqiNP_390403.1. NC_000964.3.
WP_003237058.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14454; CAB14454; BSU25250.
GeneIDi11240192.
937886.
KEGGibsu:BSU25250.
PATRICi18976886. VBIBacSub10457_2632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB14454.1.
PIRiA69969.
RefSeqiNP_390403.1. NC_000964.3.
WP_003237058.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FV6X-ray1.95A/B63-212[»]
3FWRX-ray2.45A/B63-212[»]
3FWSX-ray2.03A/B63-212[»]
ProteinModelPortaliO34994.
SMRiO34994. Positions 5-57, 64-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO34994. 2 interactions.
STRINGi224308.Bsubs1_010100013806.

Proteomic databases

PaxDbiO34994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14454; CAB14454; BSU25250.
GeneIDi11240192.
937886.
KEGGibsu:BSU25250.
PATRICi18976886. VBIBacSub10457_2632.

Phylogenomic databases

eggNOGiCOG0517. LUCA.
HOGENOMiHOG000039552.
InParanoidiO34994.
OMAiSVIMTRM.
PhylomeDBiO34994.

Enzyme and pathway databases

BioCyciBSUB:BSU25250-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO34994.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR013196. HTH_11.
IPR016842. UCP026546_HTH-CBS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF08279. HTH_11. 1 hit.
[Graphical view]
PIRSFiPIRSF026546. UCP026546_CBS_YqzB. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCPN_BACSU
AccessioniPrimary (citable) accession number: O34994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.