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Protein

Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA

Gene

opuCA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a high affinity multicomponent binding-protein-dependent transport system for glycine betaine, carnitine and choline; probably responsible for energy coupling to the transport system.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 42ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU33830-MONOMER.

Protein family/group databases

TCDBi3.A.1.12.4. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA
Gene namesi
Name:opuCA
Synonyms:yvbE
Ordered Locus Names:BSU33830
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000926771 – 380Glycine betaine/carnitine/choline transport ATP-binding protein OpuCAAdd BLAST380

Proteomic databases

PaxDbiO34992.
PRIDEiO34992.

Expressioni

Inductioni

Repressed by OpcR.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (OpuCA), two transmembrane proteins (OpuCB and OpuCD) and a solute-binding protein (OpuCC).1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018351.

Structurei

3D structure databases

ProteinModelPortaliO34992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 236ABC transporterPROSITE-ProRule annotationAdd BLAST235
Domaini255 – 314CBS 1PROSITE-ProRule annotationAdd BLAST60
Domaini315 – 373CBS 2PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG4108IJ8. Bacteria.
COG1125. LUCA.
InParanoidiO34992.
KOiK05847.
OMAiWGEEDQL.
PhylomeDBiO34992.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005892. Gly-betaine_transp_ATP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF00571. CBS. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01186. proV. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLEQVSKV YKGGKKAVNS IDLDIAKGEF ICFIGPSGCG KTTTMKMINR
60 70 80 90 100
LIEPSSGRIF IDGENIMEQD PVELRRKIGY VIQQIGLFPH MTIQQNISLV
110 120 130 140 150
PKLLKWPEEK RKERARELLK LVDMGPEYLD RYPHELSGGQ QQRIGVLRAL
160 170 180 190 200
AAEPPLILMD EPFGALDPIT RDSLQEEFKK LQRTLNKTIV FVTHDMDEAI
210 220 230 240 250
KLADRIVILK AGEIVQVGTP DEILRNPANE FVEEFIGKER LIQSRPDIER
260 270 280 290 300
VEQMMNRTPV TVSADKTLSQ AIQLMREKRV DSLLVVDRQN VLKGYVDVEM
310 320 330 340 350
IDQNRKKASI VGDVYRSDIY TVQKGALLRD TVRKILKQGI KYVPVVDEQN
360 370 380
HLAGIVTRAS LVDIVYDSIW GDEENQLMTI
Length:380
Mass (Da):43,247
Last modified:January 1, 1998 - v1
Checksum:iA10E14DCBF1866A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009352 Genomic DNA. Translation: AAB63768.1.
AL009126 Genomic DNA. Translation: CAB15388.1.
PIRiC69670.
RefSeqiNP_391263.1. NC_000964.3.
WP_003243370.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15388; CAB15388; BSU33830.
GeneIDi937136.
KEGGibsu:BSU33830.
PATRICi18978766. VBIBacSub10457_3546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009352 Genomic DNA. Translation: AAB63768.1.
AL009126 Genomic DNA. Translation: CAB15388.1.
PIRiC69670.
RefSeqiNP_391263.1. NC_000964.3.
WP_003243370.1. NZ_JNCM01000033.1.

3D structure databases

ProteinModelPortaliO34992.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018351.

Protein family/group databases

TCDBi3.A.1.12.4. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiO34992.
PRIDEiO34992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15388; CAB15388; BSU33830.
GeneIDi937136.
KEGGibsu:BSU33830.
PATRICi18978766. VBIBacSub10457_3546.

Phylogenomic databases

eggNOGiENOG4108IJ8. Bacteria.
COG1125. LUCA.
InParanoidiO34992.
KOiK05847.
OMAiWGEEDQL.
PhylomeDBiO34992.

Enzyme and pathway databases

BioCyciBSUB:BSU33830-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005892. Gly-betaine_transp_ATP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF00571. CBS. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01186. proV. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPUCA_BACSU
AccessioniPrimary (citable) accession number: O34992
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.