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O34925

- DEOD_BACSU

UniProt

O34925 - DEOD_BACSU

Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Cleavage of adenosine and its derivatives.

    Catalytic activityi

    Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
    Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.

    GO - Molecular functioni

    1. purine-nucleoside phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. purine nucleoside metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciBSUB:BSU19630-MONOMER.
    SABIO-RKO34925.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Purine nucleoside phosphorylase DeoD-type (EC:2.4.2.1)
    Short name:
    PNP
    Alternative name(s):
    Purine nucleoside phosphorylase II
    Short name:
    PU-NPase II
    Gene namesi
    Name:deoD
    Synonyms:punB
    Ordered Locus Names:BSU19630
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU19630. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Purine nucleoside phosphorylase DeoD-typePRO_0000063121Add
    BLAST

    Proteomic databases

    PaxDbiO34925.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    IntActiO34925. 1 interaction.
    MINTiMINT-8366691.
    STRINGi224308.BSU19630.

    Structurei

    Secondary structure

    1
    233
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 113
    Beta strandi14 – 185
    Helixi22 – 3211
    Beta strandi34 – 407
    Helixi42 – 443
    Beta strandi47 – 526
    Beta strandi55 – 606
    Helixi66 – 8015
    Beta strandi84 – 9310
    Beta strandi95 – 984
    Beta strandi103 – 11210
    Helixi115 – 1206
    Helixi131 – 14414
    Beta strandi148 – 1558
    Helixi166 – 1716
    Beta strandi176 – 1805
    Helixi181 – 19010
    Beta strandi194 – 20411
    Turni205 – 2073
    Helixi213 – 22715
    Turni228 – 2303

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4D8VX-ray2.35A/B1-233[»]
    4D8XX-ray2.65A1-233[»]
    4D8YX-ray1.61A/B/C/D/E/F1-233[»]
    4D98X-ray1.70A/B1-233[»]
    4D9HX-ray1.91A/B1-233[»]
    4DA0X-ray2.95A1-233[»]
    4DA6X-ray1.70A1-233[»]
    4DA7X-ray2.05A1-233[»]
    4DA8X-ray2.60A1-233[»]
    4DABX-ray1.85A1-233[»]
    4DAEX-ray2.35A1-233[»]
    4DANX-ray2.56A/B1-233[»]
    4DAOX-ray2.22A/B1-233[»]
    4DARX-ray3.15A1-233[»]
    ProteinModelPortaliO34925.
    SMRiO34925. Positions 1-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PNP/UDP phosphorylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0813.
    HOGENOMiHOG000274896.
    KOiK03784.
    OMAiECYNEVR.
    OrthoDBiEOG6BKJC5.
    PhylomeDBiO34925.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01627. Pur_nucleosid_phosp.
    InterProiIPR004402. DeoD-type.
    IPR018017. Nucleoside_phosphorylase.
    IPR018016. Nucleoside_phosphorylase_CS.
    IPR000845. Nucleoside_phosphorylase_d.
    [Graphical view]
    PANTHERiPTHR21234. PTHR21234. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR00107. deoD. 1 hit.
    PROSITEiPS01232. PNP_UDP_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O34925-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVHIGAEKG QIADTVLLPG DPLRAKFIAE TYLENVECYN EVRGMYGFTG    50
    TYKGKKISVQ GTGMGVPSIS IYVNELIQSY DVQNLIRVGS CGAIRKDVKV 100
    RDVILAMTSS TDSQMNRVAF GSVDFAPCAD FELLKNAYDA AKDKGVPVTV 150
    GSVFTADQFY NDDSQIEKLA KYGVLGVEME TTALYTLAAK HGRKALSILT 200
    VSDHVLTGEE TTAEERQTTF HDMIEVALHS VSQ 233
    Length:233
    Mass (Da):25,378
    Last modified:January 1, 1998 - v1
    Checksum:i645FD21146E8F613
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF015775 Genomic DNA. Translation: AAB72065.1.
    AF006665 Genomic DNA. Translation: AAB81164.1.
    AL009126 Genomic DNA. Translation: CAB13854.1.
    PIRiD69614.
    RefSeqiNP_389844.1. NC_000964.3.
    WP_003231176.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB13854; CAB13854; BSU19630.
    GeneIDi940038.
    KEGGibsu:BSU19630.
    PATRICi18975779. VBIBacSub10457_2080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF015775 Genomic DNA. Translation: AAB72065.1 .
    AF006665 Genomic DNA. Translation: AAB81164.1 .
    AL009126 Genomic DNA. Translation: CAB13854.1 .
    PIRi D69614.
    RefSeqi NP_389844.1. NC_000964.3.
    WP_003231176.1. NZ_CM000487.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4D8V X-ray 2.35 A/B 1-233 [» ]
    4D8X X-ray 2.65 A 1-233 [» ]
    4D8Y X-ray 1.61 A/B/C/D/E/F 1-233 [» ]
    4D98 X-ray 1.70 A/B 1-233 [» ]
    4D9H X-ray 1.91 A/B 1-233 [» ]
    4DA0 X-ray 2.95 A 1-233 [» ]
    4DA6 X-ray 1.70 A 1-233 [» ]
    4DA7 X-ray 2.05 A 1-233 [» ]
    4DA8 X-ray 2.60 A 1-233 [» ]
    4DAB X-ray 1.85 A 1-233 [» ]
    4DAE X-ray 2.35 A 1-233 [» ]
    4DAN X-ray 2.56 A/B 1-233 [» ]
    4DAO X-ray 2.22 A/B 1-233 [» ]
    4DAR X-ray 3.15 A 1-233 [» ]
    ProteinModelPortali O34925.
    SMRi O34925. Positions 1-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O34925. 1 interaction.
    MINTi MINT-8366691.
    STRINGi 224308.BSU19630.

    Proteomic databases

    PaxDbi O34925.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB13854 ; CAB13854 ; BSU19630 .
    GeneIDi 940038.
    KEGGi bsu:BSU19630.
    PATRICi 18975779. VBIBacSub10457_2080.

    Organism-specific databases

    GenoListi BSU19630. [Micado ]

    Phylogenomic databases

    eggNOGi COG0813.
    HOGENOMi HOG000274896.
    KOi K03784.
    OMAi ECYNEVR.
    OrthoDBi EOG6BKJC5.
    PhylomeDBi O34925.

    Enzyme and pathway databases

    BioCyci BSUB:BSU19630-MONOMER.
    SABIO-RK O34925.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01627. Pur_nucleosid_phosp.
    InterProi IPR004402. DeoD-type.
    IPR018017. Nucleoside_phosphorylase.
    IPR018016. Nucleoside_phosphorylase_CS.
    IPR000845. Nucleoside_phosphorylase_d.
    [Graphical view ]
    PANTHERi PTHR21234. PTHR21234. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR00107. deoD. 1 hit.
    PROSITEi PS01232. PNP_UDP_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the Bacillus subtilis 168 chromosome region between the sspC and odhA loci (184 degrees-180 degrees)."
      Ghim S.-Y., Choi S.-K., Shin B.-S., Jeong Y.-M., Sorokin A., Ehrlich S.D., Park S.-H.
      DNA Res. 5:195-201(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiDEOD_BACSU
    AccessioniPrimary (citable) accession number: O34925
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3