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O34899

- PDUO_BACSU

UniProt

O34899 - PDUO_BACSU

Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

yvqK

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
    ATP + cobinamide = triphosphate + adenosylcobinamide.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei22 – 221ATPBy similarity
    Binding sitei154 – 1541ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi5 – 139ATPBy similarity
    Nucleotide bindingi130 – 1356ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
    2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBSUB:BSU33150-MONOMER.
    UniPathwayiUPA00148; UER00233.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
    Alternative name(s):
    Cob(I)alamin adenosyltransferase
    Gene namesi
    Name:yvqK
    Ordered Locus Names:BSU33150
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU33150.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000360832Add
    BLAST

    Proteomic databases

    PaxDbiO34899.

    Interactioni

    Subunit structurei

    Homotrimer.1 Publication

    Protein-protein interaction databases

    STRINGi224308.BSU33150.

    Structurei

    Secondary structure

    1
    193
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi24 – 4724
    Beta strandi50 – 523
    Helixi54 – 7522
    Helixi87 – 10317
    Helixi117 – 14226
    Helixi147 – 17024

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RTYX-ray2.40A/B/C1-193[»]
    ProteinModelPortaliO34899.
    SMRiO34899. Positions 23-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO34899.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2096.
    HOGENOMiHOG000291639.
    OrthoDBiEOG6SZ1P1.
    PhylomeDBiO34899.

    Family and domain databases

    Gene3Di1.20.1200.10. 1 hit.
    InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
    IPR029499. PduO-typ.
    [Graphical view]
    PfamiPF01923. Cob_adeno_trans. 1 hit.
    [Graphical view]
    ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF89028. SSF89028. 1 hit.
    TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O34899-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLYTKTGDK GQTGLVGGRT DKDSLRVESY GTIDELNSFI GLALAELSGQ    50
    PGFEDLTAEL LTIQHELFDC GGDLAIVTER KDYKLTEESV SFLETRIDAY 100
    TAEAPELKKF ILPGGSKCAS LLHIARTITR RAERRVVALM KSEEIHETVL 150
    RYLNRLSDYF FAAARVVNAR SGIGDVEYER SAIVFRDRNS SES 193
    Length:193
    Mass (Da):21,504
    Last modified:July 28, 2009 - v2
    Checksum:i3FD1165F90E8526E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631A → G in CAA11738. (PubMed:9639930)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223978 Genomic DNA. Translation: CAA11738.1.
    AL009126 Genomic DNA. Translation: CAB15305.2.
    PIRiD70046.
    RefSeqiNP_391195.2. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15305; CAB15305; BSU33150.
    GeneIDi935972.
    KEGGibsu:BSU33150.
    PATRICi18978620. VBIBacSub10457_3473.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223978 Genomic DNA. Translation: CAA11738.1 .
    AL009126 Genomic DNA. Translation: CAB15305.2 .
    PIRi D70046.
    RefSeqi NP_391195.2. NC_000964.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RTY X-ray 2.40 A/B/C 1-193 [» ]
    ProteinModelPortali O34899.
    SMRi O34899. Positions 23-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU33150.

    Proteomic databases

    PaxDbi O34899.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15305 ; CAB15305 ; BSU33150 .
    GeneIDi 935972.
    KEGGi bsu:BSU33150.
    PATRICi 18978620. VBIBacSub10457_3473.

    Organism-specific databases

    GenoListi BSU33150.

    Phylogenomic databases

    eggNOGi COG2096.
    HOGENOMi HOG000291639.
    OrthoDBi EOG6SZ1P1.
    PhylomeDBi O34899.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00233 .
    BioCyci BSUB:BSU33150-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O34899.

    Family and domain databases

    Gene3Di 1.20.1200.10. 1 hit.
    InterProi IPR016030. AdoCbl_synth_CblAdoTrfase-like.
    IPR029499. PduO-typ.
    [Graphical view ]
    Pfami PF01923. Cob_adeno_trans. 1 hit.
    [Graphical view ]
    ProDomi PD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF89028. SSF89028. 1 hit.
    TIGRFAMsi TIGR00636. PduO_Nterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The yvsA-yvqA (293 degrees - 289 degrees) region of the Bacillus subtilis chromosome containing genes involved in metal ion uptake and a putative sigma factor."
      Wipat A., Brignell C.S., Guy J.B., Rose M., Emmerson P.T., Harwood C.R.
      Microbiology 144:1593-1600(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
      Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
      Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 163.
    4. Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH PHOSPHATE, SUBUNIT.

    Entry informationi

    Entry nameiPDUO_BACSU
    AccessioniPrimary (citable) accession number: O34899
    Secondary accession number(s): Q7B2J8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3