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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

yvqK

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Cob(I)yrinic acid a,c-diamide adenosyltransferase (yvqK)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22ATPBy similarity1
Binding sitei154ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi5 – 13ATPBy similarity9
Nucleotide bindingi130 – 135ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCobalamin biosynthesis, Porphyrin biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU33150-MONOMER
UniPathwayiUPA00148; UER00233

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Gene namesi
Name:yvqK
Ordered Locus Names:BSU33150
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003608321 – 193Cob(I)yrinic acid a,c-diamide adenosyltransferaseAdd BLAST193

Proteomic databases

PaxDbiO34899
PRIDEiO34899

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017991

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 47Combined sources24
Beta strandi50 – 52Combined sources3
Helixi54 – 75Combined sources22
Helixi87 – 103Combined sources17
Helixi117 – 142Combined sources26
Helixi147 – 170Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RTYX-ray2.40A/B/C1-193[»]
ProteinModelPortaliO34899
SMRiO34899
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO34899

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108WBT Bacteria
COG2096 LUCA
HOGENOMiHOG000291639
InParanoidiO34899
KOiK00798
OMAiPRQYLNR
PhylomeDBiO34899

Family and domain databases

Gene3Di1.20.1200.10, 1 hit
InterProiView protein in InterPro
IPR016030 CblAdoTrfase-like
IPR036451 CblAdoTrfase-like_sf
IPR029499 PduO-typ
PANTHERiPTHR12213 PTHR12213, 1 hit
PfamiView protein in Pfam
PF01923 Cob_adeno_trans, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007457 AdoCbl_syn_CblAdoTrfase_PduO_N, 1 hit
SUPFAMiSSF89028 SSF89028, 1 hit
TIGRFAMsiTIGR00636 PduO_Nterm, 1 hit

Sequencei

Sequence statusi: Complete.

O34899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYTKTGDK GQTGLVGGRT DKDSLRVESY GTIDELNSFI GLALAELSGQ
60 70 80 90 100
PGFEDLTAEL LTIQHELFDC GGDLAIVTER KDYKLTEESV SFLETRIDAY
110 120 130 140 150
TAEAPELKKF ILPGGSKCAS LLHIARTITR RAERRVVALM KSEEIHETVL
160 170 180 190
RYLNRLSDYF FAAARVVNAR SGIGDVEYER SAIVFRDRNS SES
Length:193
Mass (Da):21,504
Last modified:July 28, 2009 - v2
Checksum:i3FD1165F90E8526E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163A → G in CAA11738 (PubMed:9639930).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223978 Genomic DNA Translation: CAA11738.1
AL009126 Genomic DNA Translation: CAB15305.2
PIRiD70046
RefSeqiNP_391195.2, NC_000964.3
WP_003228501.1, NZ_JNCM01000033.1

Genome annotation databases

EnsemblBacteriaiCAB15305; CAB15305; BSU33150
GeneIDi935972
KEGGibsu:BSU33150
PATRICifig|224308.179.peg.3594

Entry informationi

Entry nameiPDUO_BACSU
AccessioniPrimary (citable) accession number: O34899
Secondary accession number(s): Q7B2J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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