Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

yvqK

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Cob(I)yrinic acid a,c-diamide adenosyltransferase (yvqK)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22ATPBy similarity1
Binding sitei154ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi5 – 13ATPBy similarity9
Nucleotide bindingi130 – 135ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cobalamin biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU33150-MONOMER.
UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Gene namesi
Name:yvqK
Ordered Locus Names:BSU33150
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003608321 – 193Cob(I)yrinic acid a,c-diamide adenosyltransferaseAdd BLAST193

Proteomic databases

PaxDbiO34899.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017991.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 47Combined sources24
Beta strandi50 – 52Combined sources3
Helixi54 – 75Combined sources22
Helixi87 – 103Combined sources17
Helixi117 – 142Combined sources26
Helixi147 – 170Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RTYX-ray2.40A/B/C1-193[»]
ProteinModelPortaliO34899.
SMRiO34899.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO34899.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108WBT. Bacteria.
COG2096. LUCA.
HOGENOMiHOG000291639.
InParanoidiO34899.
KOiK00798.
OMAiGADLCTP.
PhylomeDBiO34899.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR029499. PduO-typ.
[Graphical view]
PfamiPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89028. SSF89028. 1 hit.
TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.

Sequencei

Sequence statusi: Complete.

O34899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYTKTGDK GQTGLVGGRT DKDSLRVESY GTIDELNSFI GLALAELSGQ
60 70 80 90 100
PGFEDLTAEL LTIQHELFDC GGDLAIVTER KDYKLTEESV SFLETRIDAY
110 120 130 140 150
TAEAPELKKF ILPGGSKCAS LLHIARTITR RAERRVVALM KSEEIHETVL
160 170 180 190
RYLNRLSDYF FAAARVVNAR SGIGDVEYER SAIVFRDRNS SES
Length:193
Mass (Da):21,504
Last modified:July 28, 2009 - v2
Checksum:i3FD1165F90E8526E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163A → G in CAA11738 (PubMed:9639930).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223978 Genomic DNA. Translation: CAA11738.1.
AL009126 Genomic DNA. Translation: CAB15305.2.
PIRiD70046.
RefSeqiNP_391195.2. NC_000964.3.
WP_003228501.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15305; CAB15305; BSU33150.
GeneIDi935972.
KEGGibsu:BSU33150.
PATRICi18978620. VBIBacSub10457_3473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223978 Genomic DNA. Translation: CAA11738.1.
AL009126 Genomic DNA. Translation: CAB15305.2.
PIRiD70046.
RefSeqiNP_391195.2. NC_000964.3.
WP_003228501.1. NZ_JNCM01000033.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RTYX-ray2.40A/B/C1-193[»]
ProteinModelPortaliO34899.
SMRiO34899.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017991.

Proteomic databases

PaxDbiO34899.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15305; CAB15305; BSU33150.
GeneIDi935972.
KEGGibsu:BSU33150.
PATRICi18978620. VBIBacSub10457_3473.

Phylogenomic databases

eggNOGiENOG4108WBT. Bacteria.
COG2096. LUCA.
HOGENOMiHOG000291639.
InParanoidiO34899.
KOiK00798.
OMAiGADLCTP.
PhylomeDBiO34899.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00233.
BioCyciBSUB:BSU33150-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO34899.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR029499. PduO-typ.
[Graphical view]
PfamiPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89028. SSF89028. 1 hit.
TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDUO_BACSU
AccessioniPrimary (citable) accession number: O34899
Secondary accession number(s): Q7B2J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.