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Protein

Septation ring formation regulator EzrA

Gene

ezrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of cell division Source: CACAO
  • septin ring assembly Source: CACAO
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciBSUB:BSU29610-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Septation ring formation regulator EzrA
Gene namesi
Name:ezrA
Synonyms:ytwP
Ordered Locus Names:BSU29610
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22ExtracellularSequence analysis
Transmembranei3 – 2119HelicalSequence analysisAdd
BLAST
Topological domaini22 – 562541CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Septation ring formation regulator EzrAPRO_0000172870Add
BLAST

Proteomic databases

PaxDbiO34894.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ftsAP282645EBI-1567579,EBI-2122615
ftsZP178654EBI-1567579,EBI-1569853

Protein-protein interaction databases

IntActiO34894. 10 interactions.
STRINGi224308.Bsubs1_010100016151.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UXVX-ray3.96A22-562[»]
ProteinModelPortaliO34894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili109 – 15850Sequence analysisAdd
BLAST
Coiled coili239 – 27537Sequence analysisAdd
BLAST
Coiled coili311 – 34030Sequence analysisAdd
BLAST
Coiled coili376 – 529154Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the EzrA family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4477. LUCA.
HOGENOMiHOG000015629.
InParanoidiO34894.
KOiK06286.
OMAiFRSQNHI.
PhylomeDBiO34894.

Family and domain databases

HAMAPiMF_00728. EzrA. 1 hit.
InterProiIPR010379. EzrA.
[Graphical view]
PfamiPF06160. EzrA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVIGLLIV LLALFAAGYF FRKKIYAEID RLESWKIEIL NRSIVEEMSK
60 70 80 90 100
IKHLKMTGQT EEFFEKWREE WDEIVTAHMP KVEELLYDAE ENADKYRFKK
110 120 130 140 150
ANQVLVHIDD LLTAAESSIE KILREISDLV TSEEKSREEI EQVRERYSKS
160 170 180 190 200
RKNLLAYSHL YGELYDSLEK DLDEIWSGIK QFEEETEGGN YITARKVLLE
210 220 230 240 250
QDRNLERLQS YIDDVPKLLA DCKQTVPGQI AKLKDGYGEM KEKGYKLEHI
260 270 280 290 300
QLDKELENLS NQLKRAEHVL MTELDIDEAS AILQLIDENI QSVYQQLEGE
310 320 330 340 350
VEAGQSVLSK MPELIIAYDK LKEEKEHTKA ETELVKESYR LTAGELGKQQ
360 370 380 390 400
AFEKRLDEIG KLLSSVKDKL DAEHVAYSLL VEEVASIEKQ IEEVKKEHAE
410 420 430 440 450
YRENLQALRK EELQARETLS NLKKTISETA RLLKTSNIPG IPSHIQEMLE
460 470 480 490 500
NAHHHIQETV NQLNELPLNM EEAGAHLKQA EDIVNRASRE SEELVEQVIL
510 520 530 540 550
IEKIIQFGNR FRSQNHILSE QLKEAERRFY AFDYDDSYEI AAAAVEKAAP
560
GAVEKIKADI SA
Length:562
Mass (Da):64,996
Last modified:January 1, 1998 - v1
Checksum:i9AD2D58A76A08FDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00306.1.
AL009126 Genomic DNA. Translation: CAB14939.1.
PIRiG70002.
RefSeqiNP_390839.1. NC_000964.3.
WP_003229320.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14939; CAB14939; BSU29610.
GeneIDi937337.
KEGGibsu:BSU29610.
PATRICi18977826. VBIBacSub10457_3101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00306.1.
AL009126 Genomic DNA. Translation: CAB14939.1.
PIRiG70002.
RefSeqiNP_390839.1. NC_000964.3.
WP_003229320.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UXVX-ray3.96A22-562[»]
ProteinModelPortaliO34894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO34894. 10 interactions.
STRINGi224308.Bsubs1_010100016151.

Proteomic databases

PaxDbiO34894.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14939; CAB14939; BSU29610.
GeneIDi937337.
KEGGibsu:BSU29610.
PATRICi18977826. VBIBacSub10457_3101.

Phylogenomic databases

eggNOGiCOG4477. LUCA.
HOGENOMiHOG000015629.
InParanoidiO34894.
KOiK06286.
OMAiFRSQNHI.
PhylomeDBiO34894.

Enzyme and pathway databases

BioCyciBSUB:BSU29610-MONOMER.

Family and domain databases

HAMAPiMF_00728. EzrA. 1 hit.
InterProiIPR010379. EzrA.
[Graphical view]
PfamiPF06160. EzrA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEZRA_BACSU
AccessioniPrimary (citable) accession number: O34894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.