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Protein

Putative UDP-glucose 6-dehydrogenase YtcA

Gene

ytcA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid.By similarity

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase YwqF (ywqF), Putative UDP-glucose 6-dehydrogenase YtcA (ytcA), UDP-glucose 6-dehydrogenase TuaD (tuaD)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei259By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 19NADSequence analysisAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cell wall biogenesis/degradation

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSUB:BSU30860-MONOMER.
UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative UDP-glucose 6-dehydrogenase YtcA (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:ytcA
Ordered Locus Names:BSU30860
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000037998024 – 428Putative UDP-glucose 6-dehydrogenase YtcAAdd BLAST405

Proteomic databases

PaxDbiO34862.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100016786.

Structurei

3D structure databases

ProteinModelPortaliO34862.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1004. LUCA.
HOGENOMiHOG000153773.
InParanoidiO34862.
KOiK00012.
OMAiNRYLHAG.
PhylomeDBiO34862.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O34862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKICVVGAGY VGLTLSAALA SIGHDMICTD KDVKKIGQLK KGVIPFYEPG
60 70 80 90 100
LSDAILRCGN LSFSSEVKSS MEECPVIFIA VGTPPRSDGS ADTKALQSVI
110 120 130 140 150
GDLSEAIRSY KTIITKSTVP PGTNENIAKQ LIASGVSKNL FNIVSNPEFL
160 170 180 190 200
REGNALYDML HPDKTVIGVQ EEDHVSAAIV KSIYKHIDTP FIVTSLAGAE
210 220 230 240 250
LIKYANNFFL AAKISFINEM ARICEAYQSD ISDISRAIGL DPRIGKHFLQ
260 270 280 290 300
AGIGYGGSCF PKDLQALQFA AQEKNTETFL LRAVQHINDT QLGLYIKKIQ
310 320 330 340 350
SFFETLQGKK AAVLGISFKP NTDDIRNSQA VRLMERLAEL GCDVHAYDPE
360 370 380 390 400
AVLPEHLRQH VTQHSQAFDA IEESDFLFLA TEWSEFLAFD WKKAADIMKG
410 420
RLVIDGRNVL KKELIEACGL ICTGVGRP
Length:428
Mass (Da):46,833
Last modified:January 1, 1998 - v1
Checksum:i70A68AAE12178384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00367.1.
AL009126 Genomic DNA. Translation: CAB15064.1.
PIRiG69988.
RefSeqiNP_390964.1. NC_000964.3.
WP_004398478.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB15064; CAB15064; BSU30860.
GeneIDi936155.
KEGGibsu:BSU30860.
PATRICi18978078. VBIBacSub10457_3227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00367.1.
AL009126 Genomic DNA. Translation: CAB15064.1.
PIRiG69988.
RefSeqiNP_390964.1. NC_000964.3.
WP_004398478.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliO34862.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100016786.

Proteomic databases

PaxDbiO34862.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15064; CAB15064; BSU30860.
GeneIDi936155.
KEGGibsu:BSU30860.
PATRICi18978078. VBIBacSub10457_3227.

Phylogenomic databases

eggNOGiCOG1004. LUCA.
HOGENOMiHOG000153773.
InParanoidiO34862.
KOiK00012.
OMAiNRYLHAG.
PhylomeDBiO34862.

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491.
BioCyciBSUB:BSU30860-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYTCA_BACSU
AccessioniPrimary (citable) accession number: O34862
Secondary accession number(s): Q795N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.