Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative UDP-glucose 6-dehydrogenase YtcA

Gene

ytcA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid.By similarity

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase YwqF (ywqF), Putative UDP-glucose 6-dehydrogenase YtcA (ytcA), UDP-glucose 6-dehydrogenase TuaD (tuaD)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei259By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 19NADSequence analysisAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell wall biogenesis/degradation
LigandNAD

Enzyme and pathway databases

BioCyciBSUB:BSU30860-MONOMER
UniPathwayiUPA00038; UER00491

Names & Taxonomyi

Protein namesi
Recommended name:
Putative UDP-glucose 6-dehydrogenase YtcA (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:ytcA
Ordered Locus Names:BSU30860
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000037998024 – 428Putative UDP-glucose 6-dehydrogenase YtcAAdd BLAST405

Proteomic databases

PaxDbiO34862
PRIDEiO34862

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100016786

Structurei

3D structure databases

ProteinModelPortaliO34862
SMRiO34862
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1004 LUCA
HOGENOMiHOG000153773
InParanoidiO34862
KOiK00012
OMAiKYADNAF
PhylomeDBiO34862

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028357 UDPglc_DH_bac
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500134 UDPglc_DH_bac, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O34862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKICVVGAGY VGLTLSAALA SIGHDMICTD KDVKKIGQLK KGVIPFYEPG
60 70 80 90 100
LSDAILRCGN LSFSSEVKSS MEECPVIFIA VGTPPRSDGS ADTKALQSVI
110 120 130 140 150
GDLSEAIRSY KTIITKSTVP PGTNENIAKQ LIASGVSKNL FNIVSNPEFL
160 170 180 190 200
REGNALYDML HPDKTVIGVQ EEDHVSAAIV KSIYKHIDTP FIVTSLAGAE
210 220 230 240 250
LIKYANNFFL AAKISFINEM ARICEAYQSD ISDISRAIGL DPRIGKHFLQ
260 270 280 290 300
AGIGYGGSCF PKDLQALQFA AQEKNTETFL LRAVQHINDT QLGLYIKKIQ
310 320 330 340 350
SFFETLQGKK AAVLGISFKP NTDDIRNSQA VRLMERLAEL GCDVHAYDPE
360 370 380 390 400
AVLPEHLRQH VTQHSQAFDA IEESDFLFLA TEWSEFLAFD WKKAADIMKG
410 420
RLVIDGRNVL KKELIEACGL ICTGVGRP
Length:428
Mass (Da):46,833
Last modified:January 1, 1998 - v1
Checksum:i70A68AAE12178384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA Translation: AAC00367.1
AL009126 Genomic DNA Translation: CAB15064.1
PIRiG69988
RefSeqiNP_390964.1, NC_000964.3
WP_004398478.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB15064; CAB15064; BSU30860
GeneIDi936155
KEGGibsu:BSU30860
PATRICifig|224308.179.peg.3345

Similar proteinsi

Entry informationi

Entry nameiYTCA_BACSU
AccessioniPrimary (citable) accession number: O34862
Secondary accession number(s): Q795N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health