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Protein

Argininosuccinate lyase

Gene

argH

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU29440-MONOMER.
UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:BSU29440
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001377401 – 461Argininosuccinate lyaseAdd BLAST461

Proteomic databases

PaxDbiO34858.

Interactioni

Protein-protein interaction databases

IntActiO34858. 4 interactors.
STRINGi224308.Bsubs1_010100016066.

Structurei

3D structure databases

ProteinModelPortaliO34858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
InParanoidiO34858.
KOiK01755.
OMAiAHHLMAY.
PhylomeDBiO34858.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLWGGRFQ KTPEKWVDEF GASISFDQNL VAEDITGSLA HAAMLKKCGI
60 70 80 90 100
LTAEEELKIR EGLNTLLQKA EEGALEFSVD YEDIHLNIEK MLIDEIGPLG
110 120 130 140 150
GKLHTGRSRN DQVATDMHLY LKNHVGHIIE LIEAFQSALI EKAEANVETI
160 170 180 190 200
LPGYTHLQRA QPISFAHHLL AYFWMLERDK ERFQDSMKRI NKSPLGCGAL
210 220 230 240 250
AGTTFPIDRD YSAELLGFDA IYENSLDGVS DRDFILEFLS NSSMLMMHLS
260 270 280 290 300
RFSEEIILWC SQEFKFIELD DTYATGSSMM PQKKNPDMAE LIRGKTGRVY
310 320 330 340 350
GDMMGLFTIM KGLPLAYNKD LQEDKEGMFD TVKTVEGSLQ IFTGMIQTMT
360 370 380 390 400
VNKDVMKQAT KQDFSNATEL ADYLAKKGMP FREAHEVVGK LVYTCIERGI
410 420 430 440 450
YLSDMPFGEF QQASTLFEED IYTVLDPYYA VEKRMSAGGT GFKQVEQALE
460
KAKACVAAGV C
Length:461
Mass (Da):51,929
Last modified:January 1, 1998 - v1
Checksum:i785287FE262AF7D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00321.1.
AL009126 Genomic DNA. Translation: CAB14904.1.
PIRiC69589.
RefSeqiNP_390822.1. NC_000964.3.
WP_003246018.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14904; CAB14904; BSU29440.
GeneIDi937966.
KEGGibsu:BSU29440.
PATRICi18977788. VBIBacSub10457_3082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00321.1.
AL009126 Genomic DNA. Translation: CAB14904.1.
PIRiC69589.
RefSeqiNP_390822.1. NC_000964.3.
WP_003246018.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliO34858.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO34858. 4 interactors.
STRINGi224308.Bsubs1_010100016066.

Proteomic databases

PaxDbiO34858.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14904; CAB14904; BSU29440.
GeneIDi937966.
KEGGibsu:BSU29440.
PATRICi18977788. VBIBacSub10457_3082.

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
InParanoidiO34858.
KOiK01755.
OMAiAHHLMAY.
PhylomeDBiO34858.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.
BioCyciBSUB:BSU29440-MONOMER.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARLY_BACSU
AccessioniPrimary (citable) accession number: O34858
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.