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Protein

Transcription factor FapR

Gene

fapR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism. Binds to the 5'-TTAGTANNNNNTANTAA-3' consensus sequence found in the promoter of fabHAF operon (containing fabHA and fabF genes), yhdO and fapR genes and prevents their expression. Its action is probably modulated by malonyl-CoA.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciBSUB:BSU15880-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor FapR
Alternative name(s):
Fatty acid and phospholipid biosynthesis regulator
Gene namesi
Name:fapR
Synonyms:ylpC
Ordered Locus Names:BSU15880
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001728191 – 188Transcription factor FapRAdd BLAST188

Proteomic databases

PaxDbiO34835
PRIDEiO34835

Expressioni

Inductioni

Autoregulated.1 Publication

Interactioni

Protein-protein interaction databases

IntActiO34835, 6 interactors
STRINGi224308.Bsubs1_010100008761

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 63Combined sources17
Helixi71 – 73Combined sources3
Beta strandi75 – 82Combined sources8
Turni83 – 85Combined sources3
Beta strandi86 – 92Combined sources7
Helixi95 – 97Combined sources3
Turni100 – 102Combined sources3
Helixi107 – 120Combined sources14
Beta strandi129 – 136Combined sources8
Beta strandi145 – 155Combined sources11
Beta strandi157 – 160Combined sources4
Beta strandi162 – 170Combined sources9
Beta strandi173 – 182Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F3XX-ray3.10A/B44-188[»]
2F41X-ray2.50A/B/C/D68-188[»]
ProteinModelPortaliO34835
SMRiO34835
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO34835

Family & Domainsi

Sequence similaritiesi

Belongs to the FapR family.Curated

Phylogenomic databases

eggNOGiENOG4108VVV Bacteria
COG2050 LUCA
HOGENOMiHOG000095867
OMAiGIARGHH
PhylomeDBiO34835

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_01814 Transcrip_fact_FapR, 1 hit
InterProiView protein in InterPro
IPR029069 HotDog_dom_sf
IPR006683 Thioestr_dom
IPR017275 Transcription_factor_FapR
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF03061 4HBT, 1 hit
PIRSFiPIRSF037733 Transcription_factor_FapR, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit

Sequencei

Sequence statusi: Complete.

O34835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRNKRERQE LLQQTIQATP FITDEELAGK FGVSIQTIRL DRLELSIPEL
60 70 80 90 100
RERIKNVAEK TLEDEVKSLS LDEVIGEIID LELDDQAISI LEIKQEHVFS
110 120 130 140 150
RNQIARGHHL FAQANSLAVA VIDDELALTA SADIRFTRQV KQGERVVAKA
160 170 180
KVTAVEKEKG RTVVEVNSYV GEEIVFSGRF DMYRSKHS
Length:188
Mass (Da):21,400
Last modified:January 1, 1998 - v1
Checksum:iCF38F3781C20BD63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13937 Genomic DNA Translation: CAA74247.1
AL009126 Genomic DNA Translation: CAB13461.1
PIRiA69880
RefSeqiNP_389470.1, NC_000964.3
WP_003232044.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13461; CAB13461; BSU15880
GeneIDi936595
KEGGibsu:BSU15880
PATRICifig|224308.179.peg.1728

Similar proteinsi

Entry informationi

Entry nameiFAPR_BACSU
AccessioniPrimary (citable) accession number: O34835
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health