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Protein

Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase PksC

Gene

pksC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK).2 Publications

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].1 Publication

Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87By similarity1
Active sitei193By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU17100-MONOMER.
UniPathwayiUPA01003.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase PksC (EC:2.3.1.39)
Short name:
AT
Gene namesi
Name:pksC
Ordered Locus Names:BSU17100
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003880041 – 288Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase PksCAdd BLAST288

Proteomic databases

PaxDbiO34825.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009411.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DZ6X-ray1.44A1-288[»]
ProteinModelPortaliO34825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiENOG4105CJF. Bacteria.
COG0331. LUCA.
HOGENOMiHOG000036504.
InParanoidiO34825.
KOiK15327.
OMAiQKQGMGS.
PhylomeDBiO34825.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR020801. PKS_acyl_transferase.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.

Sequencei

Sequence statusi: Complete.

O34825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITYVFPGQG SQKQGMGSGL FDEFKELTDQ ADEILGYSIK RLCLENPYSN
60 70 80 90 100
LNKTQFTQPA LYVVNALSYL KKIRDEEVKP DFVAGHSLGE YNALFAAEAF
110 120 130 140 150
DFETGLQLVR KRGELMSLIS NGGMAAVMGL NEEQVAKALK EYHLHDVDIA
160 170 180 190 200
NVNAPYQIVI SGKKDEIEKA ASLFETMTEV TMVLPLNVSG AFHSRYMNKA
210 220 230 240 250
KEEFEEFLHA FYFSPPSIPV ISNVYAKPYT YEFMKQTLAD QINHSVKWTD
260 270 280
SISYLMKKGH MEFEEVGPGN VLTGLIHRIK KDAEAMPR
Length:288
Mass (Da):32,464
Last modified:January 1, 1998 - v1
Checksum:iAFAE397EAB2FD3C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13582.1.
PIRiA69678.
RefSeqiNP_389591.1. NC_000964.3.
WP_003231821.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB13582; CAB13582; BSU17100.
GeneIDi939504.
KEGGibsu:BSU17100.
PATRICi18975227. VBIBacSub10457_1805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13582.1.
PIRiA69678.
RefSeqiNP_389591.1. NC_000964.3.
WP_003231821.1. NZ_JNCM01000035.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DZ6X-ray1.44A1-288[»]
ProteinModelPortaliO34825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009411.

Proteomic databases

PaxDbiO34825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13582; CAB13582; BSU17100.
GeneIDi939504.
KEGGibsu:BSU17100.
PATRICi18975227. VBIBacSub10457_1805.

Phylogenomic databases

eggNOGiENOG4105CJF. Bacteria.
COG0331. LUCA.
HOGENOMiHOG000036504.
InParanoidiO34825.
KOiK15327.
OMAiQKQGMGS.
PhylomeDBiO34825.

Enzyme and pathway databases

UniPathwayiUPA01003.
BioCyciBSUB:BSU17100-MONOMER.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR020801. PKS_acyl_transferase.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPKSC_BACSU
AccessioniPrimary (citable) accession number: O34825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.