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Protein

Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase PksC

Gene

pksC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK).2 Publications

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].1 Publication

Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87By similarity1
Active sitei193By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAntibiotic biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU17100-MONOMER
UniPathwayiUPA01003

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase PksC (EC:2.3.1.39)
Short name:
AT
Gene namesi
Name:pksC
Ordered Locus Names:BSU17100
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003880041 – 288Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase PksCAdd BLAST288

Proteomic databases

PaxDbiO34825
PRIDEiO34825

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009411

Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Turni14 – 19Combined sources6
Helixi20 – 23Combined sources4
Helixi25 – 35Combined sources11
Helixi39 – 45Combined sources7
Helixi47 – 52Combined sources6
Helixi54 – 76Combined sources23
Beta strandi81 – 86Combined sources6
Helixi89 – 96Combined sources8
Helixi102 – 117Combined sources16
Beta strandi121 – 129Combined sources9
Helixi132 – 141Combined sources10
Beta strandi147 – 154Combined sources8
Beta strandi157 – 163Combined sources7
Helixi164 – 175Combined sources12
Beta strandi182 – 185Combined sources4
Helixi195 – 197Combined sources3
Helixi198 – 208Combined sources11
Turni223 – 225Combined sources3
Beta strandi226 – 228Combined sources3
Helixi231 – 233Combined sources3
Helixi234 – 240Combined sources7
Helixi241 – 243Combined sources3
Helixi248 – 256Combined sources9
Beta strandi262 – 265Combined sources4
Beta strandi267 – 270Combined sources4
Helixi271 – 284Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DZ6X-ray1.44A1-288[»]
ProteinModelPortaliO34825
SMRiO34825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiENOG4105CJF Bacteria
COG0331 LUCA
HOGENOMiHOG000036504
InParanoidiO34825
KOiK15327
OMAiQKQGMGS
PhylomeDBiO34825

Family and domain databases

Gene3Di3.40.366.10, 2 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR024925 Malonyl_CoA-ACP_transAc
IPR004410 Malonyl_CoA-ACP_transAc_FabD
IPR016036 Malonyl_transacylase_ACP-bd
IPR020801 PKS_acyl_transferase
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PIRSFiPIRSF000446 Mct, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SUPFAMiSSF52151 SSF52151, 2 hits
SSF55048 SSF55048, 1 hit
TIGRFAMsiTIGR00128 fabD, 1 hit

Sequencei

Sequence statusi: Complete.

O34825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITYVFPGQG SQKQGMGSGL FDEFKELTDQ ADEILGYSIK RLCLENPYSN
60 70 80 90 100
LNKTQFTQPA LYVVNALSYL KKIRDEEVKP DFVAGHSLGE YNALFAAEAF
110 120 130 140 150
DFETGLQLVR KRGELMSLIS NGGMAAVMGL NEEQVAKALK EYHLHDVDIA
160 170 180 190 200
NVNAPYQIVI SGKKDEIEKA ASLFETMTEV TMVLPLNVSG AFHSRYMNKA
210 220 230 240 250
KEEFEEFLHA FYFSPPSIPV ISNVYAKPYT YEFMKQTLAD QINHSVKWTD
260 270 280
SISYLMKKGH MEFEEVGPGN VLTGLIHRIK KDAEAMPR
Length:288
Mass (Da):32,464
Last modified:January 1, 1998 - v1
Checksum:iAFAE397EAB2FD3C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB13582.1
PIRiA69678
RefSeqiNP_389591.1, NC_000964.3
WP_003231821.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13582; CAB13582; BSU17100
GeneIDi939504
KEGGibsu:BSU17100
PATRICifig|224308.179.peg.1853

Similar proteinsi

Entry informationi

Entry nameiPKSC_BACSU
AccessioniPrimary (citable) accession number: O34825
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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