Phosphopantetheine adenylyltransferase

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Reviewed, UniProtKB/Swiss-Prot O34797 (COAD_BACSU)

Last modified November 3, 2009. Version 80. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Phosphopantetheine adenylyltransferase
    EC=2.7.7.3
Alternative name(s):
    Pantetheine-phosphate adenylyltransferase
      Short name=PPAT
    Dephospho-CoA pyrophosphorylase

Gene names

Name:	coaD
Synonyms:	ylbI
Ordered Locus Names:	BSU15020

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity.
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the bacterial coaD family.

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Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 161

161

Phosphopantetheine adenylyltransferase HAMAP MF_00151

PRO_0000156169

Secondary structure

161

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

O34797-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: F4C23D80E359EA8F
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FASTA

161

18,179

        10         20         30         40         50         60 
MASIAVCPGS FDPVTYGHLD IIKRGAHIFE QVYVCVLNNS SKKPLFSVEE RCELLREVTK 

        70         80         90        100        110        120 
DIPNITVETS QGLLIDYAKR KNAKAILRGL RAVSDFEYEM QGTSVNRVLD ESIETFFMMT 

       130        140        150        160 
NNQYSFLSSS IVKEVARYNG SVSEFVPPEV ELALQQKFRQ G

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bacillus subtilis chromosomal region downstream nprE." Bertero M., Presecan E., Glaser P., Richou A., Danchin A. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

Z98682 Genomic DNA. Translation: CAB11355.1.
AL009126 Genomic DNA. Translation: CAB13375.1.

PIR

F69874.

RefSeq

NP_389385.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1O6B	X-ray	2.20	A	2-161	[»]

ModBase

Search...

Genome annotation databases

GeneID

936889.

GenomeReviews

Gene locus BSU15020 in contig AL009126_GR.

KEGG

bsu:BSU15020.

NMPDR

fig|224308.1.peg.1504.

Organism-specific databases

SubtiList

BG13361. coaD. [Micado]

CMR

Search...

Phylogenomic databases

HOGENOM

O34797.

OMA

AMSDFEY.

Enzyme and pathway databases

BioCyc

BSUB224308:BSU1504-MON.

BRENDA

2.7.7.3. 150.

Family and domain databases

HAMAP

MF_00151.
[Tree]

InterPro

IPR004821. Cyt_trans_rel.
IPR004820. Cytidylyltransf.
IPR001980. LPS_biosynth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]

Gene3D

G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.

Pfam

PF01467. CTP_transf_2. 1 hit.
[Graphical view]

PRINTS

PR01020. LPSBIOSNTHSS.

TIGRFAMs

TIGR01510. coaD_prev_kdtB. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.

ProtoNet

Search...

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Entry information

Entry name

COAD_BACSU

Accession

Primary (citable) accession number: O34797

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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