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O34788 (BDHA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
(R,R)-butanediol dehydrogenase
EC=1.1.1.4
Alternative name(s):
Acetoin reductase/2,3-butanediol dehydrogenase
Short name=AR/BDH
Gene names
Name:bdhA
Synonyms:ydjL
Ordered Locus Names:BSU06240
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH.

Cofactor

Zinc Potential.

Disruption phenotype

Cells lacking this gene have no acetoin reductase/2,3-butanediol dehydrogenase activity. Ref.3

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346(R,R)-butanediol dehydrogenase
PRO_0000378092

Sites

Metal binding371Zinc Potential
Metal binding701Zinc Potential
Metal binding1521Zinc Potential

Sequences

Sequence LengthMass (Da)Tools
O34788 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 5E327192D678F8A2

FASTA34637,341
        10         20         30         40         50         60 
MKAARWHNQK DIRIEHIEEP KTEPGKVKIK VKWCGICGSD LHEYLGGPIF IPVDKPHPLT 

        70         80         90        100        110        120 
NETAPVTMGH EFSGEVVEVG EGVENYKVGD RVVVEPIFAT HGHQGAYNLD EQMGFLGLAG 

       130        140        150        160        170        180 
GGGGFSEYVS VDEELLFKLP DELSYEQGAL VEPSAVALYA VRSSKLKAGD KAAVFGCGPI 

       190        200        210        220        230        240 
GLLVIEALKA AGATDIYAVE LSPERQQKAE ELGAIIVDPS KTDDVVAEIA ERTGGGVDVA 

       250        260        270        280        290        300 
FEVTGVPVVL RQAIQSTTIA GETVIVSIWE KGAEIHPNDI VIKERTVKGI IGYRDIFPAV 

       310        320        330        340 
LSLMKEGYFS ADKLVTKKIV LDDLIEEGFG ALIKEKSQVK ILVRPN

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the groESL-cotA region of the Bacillus subtilis genome, containing the restriction/modification system genes."
Kasahara Y., Nakai S., Ogasawara N., Yata K., Sadaie Y.
DNA Res. 4:335-339(1997) [PubMed: 9455482] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"The Bacillus subtilis ydjL (bdhA) gene encodes acetoin reductase/2,3-butanediol dehydrogenase."
Nicholson W.L.
Appl. Environ. Microbiol. 74:6832-6838(2008) [PubMed: 18820069] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
Strain: 168.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB007638 Genomic DNA. Translation: BAA22767.1.
AL009126 Genomic DNA. Translation: CAB12443.1.
PIRH69789.
RefSeqNP_388505.1. NC_000964.3.

3D structure databases

HSSPHSSP built from PDB template 1RJW based on UniProtKB P42328.
ProteinModelPortalO34788.
SMRO34788. Positions 1-346.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000000967; EBBACP00000000967; EBBACG00000000965.
GeneID939490.
GenomeReviewsGene locus BSU06240 in contig AL009126_GR.
KEGGbsu:BSU06240.
NMPDRfig|224308.1.peg.624.
PATRIC18972886. VBIBacSub10457_0657.

Organism-specific databases

GenoListBSU06240. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000000383.
HOGENOMHBG753318.
OMALYAVRSS.
PhylomeDBO34788.
ProtClustDBCLSK873763.

Enzyme and pathway databases

BioCycBSUB:BSU06240-MONOMER.

Family and domain databases

InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBDHA_BACSU
AccessionPrimary (citable) accession number: O34788
Secondary accession number(s): Q797C2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents