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O34779

- PRPC_BACSU

UniProt

O34779 - PRPC_BACSU

Protein

Protein phosphatase PrpC

Gene

prpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Protein phosphatase that dephosphorylates PrkC and FusA (elongation factor G). PrpC and prkC are cotranscribed, which suggests that they form a functional couple in vivo, PrpC's primary role being possibly to counter the action of PrkC. May be involved in sporulation and biofilm formation. Does not seem to be involved in stress response.3 Publications

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi36 – 361Manganese 1By similarity
    Metal bindingi36 – 361Manganese 2By similarity
    Metal bindingi37 – 371Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi195 – 1951Manganese 2By similarity
    Metal bindingi234 – 2341Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Sporulation

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciBSUB:BSU15760-MONOMER.

    Protein family/group databases

    PptaseDBiP3D040488.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase PrpC (EC:3.1.3.16)
    Gene namesi
    Name:prpC
    Synonyms:yloO
    Ordered Locus Names:BSU15760
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU15760. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Protein phosphatase PrpCPRO_0000253340Add
    BLAST

    Proteomic databases

    PaxDbiO34779.

    Interactioni

    Protein-protein interaction databases

    IntActiO34779. 1 interaction.
    STRINGi224308.BSU15760.

    Structurei

    3D structure databases

    ProteinModelPortaliO34779.
    SMRiO34779. Positions 1-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 236235PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000235782.
    KOiK01090.
    OMAiHEECQGM.
    OrthoDBiEOG65N17S.
    PhylomeDBiO34779.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O34779-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTALKTDTG KIRQHNEDDA GIFKGKDEFI LAVVADGMGG HLAGDVASKM    50
    AVKAMGEKWN EAETIPTAPS ECEKWLIEQI LSVNSKIYDH AQAHEECQGM 100
    GTTIVCALFT GKTVSVAHIG DSRCYLLQDD DFVQVTEDHS LVNELVRTGE 150
    ISREDAEHHP RKNVLTKALG TDQLVSIDTR SFDIEPGDKL LLCSDGLTNK 200
    VEGTELKDIL QSDSAPQEKV NLLVDKANQN GGEDNITAVL LELALQVEEG 250
    EDQC 254
    Length:254
    Mass (Da):27,674
    Last modified:January 1, 1998 - v1
    Checksum:iA01A30A97B47C86E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13937 Genomic DNA. Translation: CAA74266.1.
    AL009126 Genomic DNA. Translation: CAB13449.1.
    PIRiG69878.
    RefSeqiNP_389458.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB13449; CAB13449; BSU15760.
    GeneIDi935931.
    KEGGibsu:BSU15760.
    PATRICi18974959. VBIBacSub10457_1671.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13937 Genomic DNA. Translation: CAA74266.1 .
    AL009126 Genomic DNA. Translation: CAB13449.1 .
    PIRi G69878.
    RefSeqi NP_389458.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali O34779.
    SMRi O34779. Positions 1-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O34779. 1 interaction.
    STRINGi 224308.BSU15760.

    Protein family/group databases

    PptaseDBi P3D040488.

    Proteomic databases

    PaxDbi O34779.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB13449 ; CAB13449 ; BSU15760 .
    GeneIDi 935931.
    KEGGi bsu:BSU15760.
    PATRICi 18974959. VBIBacSub10457_1671.

    Organism-specific databases

    GenoListi BSU15760. [Micado ]

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000235782.
    KOi K01090.
    OMAi HEECQGM.
    OrthoDBi EOG65N17S.
    PhylomeDBi O34779.

    Enzyme and pathway databases

    BioCyci BSUB:BSU15760-MONOMER.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A 28 kbp segment from the spoVM region of the Bacillus subtilis 168 genome."
      Foulger D., Errington J.
      Microbiology 144:801-805(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Characterization of PrpC from Bacillus subtilis, a member of the PPM phosphatase family."
      Obuchowski M., Madec E., Delattre D., Boel G., Iwanicki A., Foulger D., Seror S.J.
      J. Bacteriol. 182:5634-5638(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, COFACTOR.
      Strain: 168.
    4. "Characterization of a membrane-linked Ser/Thr protein kinase in Bacillus subtilis, implicated in developmental processes."
      Madec E., Laszkiewicz A., Iwanicki A., Obuchowski M., Seror S.
      Mol. Microbiol. 46:571-586(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: 168.
    5. "The PrpC serine-threonine phosphatase and PrkC kinase have opposing physiological roles in stationary-phase Bacillus subtilis cells."
      Gaidenko T.A., Kim T.-J., Price C.W.
      J. Bacteriol. 184:6109-6114(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION OF SUBSTRATES.
      Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.

    Entry informationi

    Entry nameiPRPC_BACSU
    AccessioniPrimary (citable) accession number: O34779
    Secondary accession number(s): Q799K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3