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Protein

Major myo-inositol transporter IolT

Gene

iolT

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Major myo-inositol uptake transporter.1 Publication

Miscellaneous

When iolT is inactivated, inositol uptake is almost abolished even though iolF is active.

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in the pathway myo-inositol degradation into acetyl-CoA, which is part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciBSUB:BSU06230-MONOMER
UniPathwayiUPA00076

Protein family/group databases

TCDBi2.A.1.1.26 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Major myo-inositol transporter IolT
Gene namesi
Name:iolT
Synonyms:ydjK
Ordered Locus Names:BSU06230
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503051 – 473Major myo-inositol transporter IolTAdd BLAST473

Proteomic databases

PaxDbiO34718
PRIDEiO34718

Expressioni

Inductioni

Negatively regulated by IolR. Induced by inositol.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100003498

Structurei

3D structure databases

ProteinModelPortaliO34718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QNK Bacteria
ENOG410XNQK LUCA
HOGENOMiHOG000202868
InParanoidiO34718
KOiK06609
OMAiFQFGYDI
PhylomeDBiO34718

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

O34718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQGNQMSF LRTIILVSTF GGLLFGYDTG VLNGALPYMG EPDQLNLNAF
60 70 80 90 100
TEGLVTSSLL FGAALGAVFG GRMSDFNGRR KNILFLAVIF FISTIGCTFA
110 120 130 140 150
PNVTVMIISR FVLGIAVGGA SVTVPAYLAE MSPVESRGRM VTQNELMIVS
160 170 180 190 200
GQLLAFVFNA ILGTTMGDNS HVWRFMLVIA SLPALFLFFG MIRMPESPRW
210 220 230 240 250
LVSKGRKEDA LRVLKKIRDE KRAAAELQEI EFAFKKEDQL EKATFKDLSV
260 270 280 290 300
PWVRRIVFIG LGIAIVQQIT GVNSIMYYGT EILRNSGFQT EAALIGNIAN
310 320 330 340 350
GVISVLATFV GIWLLGRVGR RPMLMTGLIG TTTALLLIGI FSLVLEGSPA
360 370 380 390 400
LPYVVLSLTV TFLAFQQGAI SPVTWLMLSE IFPLRLRGLG MGVTVFCLWM
410 420 430 440 450
VNFAVSFTFP ILLAAIGLST TFFIFVGLGI CSVLFVKRFL PETKGLSLEQ
460 470
LEENFRAYDH SGAKKDSGAE VIG
Length:473
Mass (Da):51,633
Last modified:January 1, 1998 - v1
Checksum:i5A44A4AA09A227FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007638 Genomic DNA Translation: BAA22766.1
AL009126 Genomic DNA Translation: CAB12442.1
PIRiG69789
RefSeqiNP_388504.1, NC_000964.3
WP_003234027.1, NZ_JNCM01000032.1

Genome annotation databases

EnsemblBacteriaiCAB12442; CAB12442; BSU06230
GeneIDi936014
KEGGibsu:BSU06230
PATRICifig|224308.179.peg.675

Similar proteinsi

Entry informationi

Entry nameiIOLT_BACSU
AccessioniPrimary (citable) accession number: O34718
Secondary accession number(s): Q797C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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