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Protein

Major myo-inositol transporter IolT

Gene

iolT

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Major myo-inositol uptake transporter.1 Publication

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in the pathway myo-inositol degradation into acetyl-CoA, which is part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciBSUB:BSU06230-MONOMER.
UniPathwayiUPA00076.

Protein family/group databases

TCDBi2.A.1.1.26. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Major myo-inositol transporter IolT
Gene namesi
Name:iolT
Synonyms:ydjK
Ordered Locus Names:BSU06230
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence analysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence analysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence analysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence analysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Major myo-inositol transporter IolTPRO_0000050305Add
BLAST

Proteomic databases

PaxDbiO34718.

Expressioni

Inductioni

Negatively regulated by IolR. Induced by inositol.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100003498.

Structurei

3D structure databases

ProteinModelPortaliO34718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QNK. Bacteria.
ENOG410XNQK. LUCA.
HOGENOMiHOG000202868.
InParanoidiO34718.
KOiK06609.
OMAiESMENTA.
OrthoDBiEOG65J51S.
PhylomeDBiO34718.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQGNQMSF LRTIILVSTF GGLLFGYDTG VLNGALPYMG EPDQLNLNAF
60 70 80 90 100
TEGLVTSSLL FGAALGAVFG GRMSDFNGRR KNILFLAVIF FISTIGCTFA
110 120 130 140 150
PNVTVMIISR FVLGIAVGGA SVTVPAYLAE MSPVESRGRM VTQNELMIVS
160 170 180 190 200
GQLLAFVFNA ILGTTMGDNS HVWRFMLVIA SLPALFLFFG MIRMPESPRW
210 220 230 240 250
LVSKGRKEDA LRVLKKIRDE KRAAAELQEI EFAFKKEDQL EKATFKDLSV
260 270 280 290 300
PWVRRIVFIG LGIAIVQQIT GVNSIMYYGT EILRNSGFQT EAALIGNIAN
310 320 330 340 350
GVISVLATFV GIWLLGRVGR RPMLMTGLIG TTTALLLIGI FSLVLEGSPA
360 370 380 390 400
LPYVVLSLTV TFLAFQQGAI SPVTWLMLSE IFPLRLRGLG MGVTVFCLWM
410 420 430 440 450
VNFAVSFTFP ILLAAIGLST TFFIFVGLGI CSVLFVKRFL PETKGLSLEQ
460 470
LEENFRAYDH SGAKKDSGAE VIG
Length:473
Mass (Da):51,633
Last modified:January 1, 1998 - v1
Checksum:i5A44A4AA09A227FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007638 Genomic DNA. Translation: BAA22766.1.
AL009126 Genomic DNA. Translation: CAB12442.1.
PIRiG69789.
RefSeqiNP_388504.1. NC_000964.3.
WP_003234027.1. NZ_JNCM01000032.1.

Genome annotation databases

EnsemblBacteriaiCAB12442; CAB12442; BSU06230.
GeneIDi936014.
KEGGibsu:BSU06230.
PATRICi18972884. VBIBacSub10457_0656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007638 Genomic DNA. Translation: BAA22766.1.
AL009126 Genomic DNA. Translation: CAB12442.1.
PIRiG69789.
RefSeqiNP_388504.1. NC_000964.3.
WP_003234027.1. NZ_JNCM01000032.1.

3D structure databases

ProteinModelPortaliO34718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100003498.

Protein family/group databases

TCDBi2.A.1.1.26. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiO34718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12442; CAB12442; BSU06230.
GeneIDi936014.
KEGGibsu:BSU06230.
PATRICi18972884. VBIBacSub10457_0656.

Phylogenomic databases

eggNOGiENOG4107QNK. Bacteria.
ENOG410XNQK. LUCA.
HOGENOMiHOG000202868.
InParanoidiO34718.
KOiK06609.
OMAiESMENTA.
OrthoDBiEOG65J51S.
PhylomeDBiO34718.

Enzyme and pathway databases

UniPathwayiUPA00076.
BioCyciBSUB:BSU06230-MONOMER.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the groESL-cotA region of the Bacillus subtilis genome, containing the restriction/modification system genes."
    Kasahara Y., Nakai S., Ogasawara N., Yata K., Sadaie Y.
    DNA Res. 4:335-339(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Identification of two myo-inositol transporter genes of Bacillus subtilis."
    Yoshida K., Yamamoto Y., Omae K., Yamamoto M., Fujita Y.
    J. Bacteriol. 184:983-991(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIOLT_BACSU
AccessioniPrimary (citable) accession number: O34718
Secondary accession number(s): Q797C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 1, 1998
Last modified: February 17, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

When iolT is inactivated, inositol uptake is almost abolished even though iolF is active.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.