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O34661

- PANE_BACSU

UniProt

O34661 - PANE_BACSU

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Protein

Probable 2-dehydropantoate 2-reductase

Gene
panE, apbA, ylbQ, BSU15110
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981NADP; via amide nitrogen By similarity
Binding sitei98 – 981Substrate By similarity
Active sitei179 – 1791Proton donor By similarity
Binding sitei183 – 1831Substrate By similarity
Binding sitei187 – 1871Substrate By similarity
Binding sitei246 – 2461Substrate By similarity
Binding sitei258 – 2581NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBSUB:BSU15110-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Gene namesi
Name:panE
Synonyms:apbA, ylbQ
Ordered Locus Names:BSU15110
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU15110. [Micado]

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Probable 2-dehydropantoate 2-reductasePRO_0000157311Add
BLAST

Proteomic databases

PaxDbiO34661.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU15110.

Structurei

Secondary structure

1
298
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65
Helixi10 – 2011
Beta strandi23 – 286
Helixi32 – 4110
Beta strandi43 – 475
Beta strandi50 – 545
Beta strandi57 – 615
Beta strandi67 – 715
Helixi75 – 773
Helixi78 – 847
Beta strandi92 – 954
Beta strandi98 – 1003
Helixi101 – 1077
Beta strandi114 – 1207
Beta strandi123 – 1264
Beta strandi128 – 1369
Beta strandi140 – 1445
Helixi150 – 1534
Turni154 – 1574
Beta strandi166 – 1683
Helixi172 – 19322
Helixi199 – 2024
Helixi204 – 22118
Helixi226 – 23914
Turni240 – 2423
Helixi246 – 2538
Helixi259 – 27214
Helixi278 – 28912

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EGOX-ray1.90A/B2-297[»]
ProteinModelPortaliO34661.
SMRiO34661. Positions 10-291.

Miscellaneous databases

EvolutionaryTraceiO34661.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiQEVAFLI.
OrthoDBiEOG68SVW3.
PhylomeDBiO34661.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

O34661-1 [UniParc]FASTAAdd to Basket

« Hide

MKIGIIGGGS VGLLCAYYLS LYHDVTVVTR RQEQAAAIQS EGIRLYKGGE    50
EFRADCSADT SINSDFDLLV VTVKQHQLQS VFSSLERIGK TNILFLQNGM 100
GHIHDLKDWH VGHSIYVGIV EHGAVRKSDT AVDHTGLGAI KWSAFDDAEP 150
DRLNILFQHN HSDFPIYYET DWYRLLTGKL IVNACINPLT ALLQVKNGEL 200
LTTPAYLAFM KLVFQEACRI LKLENEEKAW ERVQAVCGQT KENRSSMLVD 250
VIGGRQTEAD AIIGYLLKEA SLQGLDAVHL EFLYGSIKAL ERNTNKVF 298
Length:298
Mass (Da):33,287
Last modified:January 1, 1998 - v1
Checksum:iA0B645A0A415FFD5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z98682 Genomic DNA. Translation: CAB11364.1.
AL009126 Genomic DNA. Translation: CAB13384.1.
PIRiF69875.
RefSeqiNP_389394.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13384; CAB13384; BSU15110.
GeneIDi936782.
KEGGibsu:BSU15110.
PATRICi18974827. VBIBacSub10457_1605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z98682 Genomic DNA. Translation: CAB11364.1 .
AL009126 Genomic DNA. Translation: CAB13384.1 .
PIRi F69875.
RefSeqi NP_389394.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EGO X-ray 1.90 A/B 2-297 [» ]
ProteinModelPortali O34661.
SMRi O34661. Positions 10-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU15110.

Proteomic databases

PaxDbi O34661.

Protocols and materials databases

DNASUi 936782.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB13384 ; CAB13384 ; BSU15110 .
GeneIDi 936782.
KEGGi bsu:BSU15110.
PATRICi 18974827. VBIBacSub10457_1605.

Organism-specific databases

GenoListi BSU15110. [Micado ]

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi QEVAFLI.
OrthoDBi EOG68SVW3.
PhylomeDBi O34661.

Enzyme and pathway databases

BioCyci BSUB:BSU15110-MONOMER.

Miscellaneous databases

EvolutionaryTracei O34661.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bacillus subtilis chromosomal region downstream nprE."
    Bertero M., Presecan E., Glaser P., Richou A., Danchin A.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiPANE_BACSU
AccessioniPrimary (citable) accession number: O34661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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