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O34660 (ALDH4_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative aldehyde dehydrogenase DhaS
EC=1.2.1.3
Gene names
Name:dhaS
Ordered Locus Names:BSU19310
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Putative aldehyde dehydrogenase DhaS
PRO_0000379509

Regions

Nucleotide binding244 – 2496NAD Potential

Sites

Active site2661 By similarity
Active site3001 By similarity

Sequences

Sequence LengthMass (Da)Tools
O34660 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 24EBC782F47034A8

FASTA49553,882
        10         20         30         40         50         60 
MSSLTMQVTK RLETFLQGTK KLYIDGKFVP SASGATFDTP NPATGETLMT LYEAQAADVD 

        70         80         90        100        110        120 
KAVKAARKAF DQGEWRTMSP ASRSRLMYKL ADLMEEHKTE LAQLETLDNG KPINETTNGD 

       130        140        150        160        170        180 
IPLAIEHMRY YAGWCTKITG QTIPVSGAYF NYTRHEPVGV VGQIIPWNFP LLMAMWKMGA 

       190        200        210        220        230        240 
ALATGCTIVL KPAEQTPLSA LYLAELIDQA GFPAGVINII PGFGEDAGEA LTNHEAVDKI 

       250        260        270        280        290        300 
AFTGSTEIGK KIMSTAAKSI KRVTLELGGK SPNILLPDAN LKKAIPGALN GVMFNQGQVC 

       310        320        330        340        350        360 
CAGSRVFIHK DQYDEVVDEM ASYAESLRQG AGLHKDTQIG PLVSKEQHER VLSYIQKGKD 

       370        380        390        400        410        420 
EGAKAVTGGS CPFEAGYFVA PTVFANVEDE MTIAKEEIFG PVLTAIPYET VDEVIERANH 

       430        440        450        460        470        480 
SEYGLAAGLW TENVKQAHYI ADRLQAGTVW VNCYNVFDAA SPFGGYKQSG LGREMGSYAL 

       490 
DNYTEVKSVW VNLED

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the Bacillus subtilis chromosome region between the terC and odhAB loci cloned in a yeast artificial chromosome."
Lapidus A., Galleron N., Sorokin A., Ehrlich D.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF027868 Genomic DNA. Translation: AAB84440.1.
AL009126 Genomic DNA. Translation: CAB13823.1.
PIRH69614.
RefSeqNP_389813.1. NC_000964.3.

3D structure databases

HSSPHSSP built from PDB template 1ZUM based on UniProtKB P05091.
ProteinModelPortalO34660.
SMRO34660. Positions 20-495.
ModBaseSearch...

Protein-protein interaction databases

STRING224308.BSU19310.

Proteomic databases

PaxDbO34660.
PRIDEO34660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB13823; CAB13823; BSU19310.
GeneID939963.
KEGGbsu:BSU19310.
PATRIC18975713. VBIBacSub10457_2047.

Organism-specific databases

GenoListBSU19310. [Micado]

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00128.
OMAEVKSVWI.
ProtClustDBCLSK2752423.

Enzyme and pathway databases

BioCycBSUB:BSU19310-MONOMER.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH4_BACSU
AccessionPrimary (citable) accession number: O34660
Secondary accession number(s): Q796C4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

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