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O34660

- ALDH4_BACSU

UniProt

O34660 - ALDH4_BACSU

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Protein

Putative aldehyde dehydrogenase DhaS

Gene

dhaS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661PROSITE-ProRule annotation
Active sitei300 – 3001PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi244 – 2496NADSequence Analysis

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSUB:BSU19310-MONOMER.
RETL1328306-WGS:GSTH-4750-MONOMER.
RETL1328306-WGS:GSTH-4814-MONOMER.
RETL1328306-WGS:GSTH-5674-MONOMER.
RETL1328306-WGS:GSTH-6387-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase DhaS (EC:1.2.1.3)
Gene namesi
Name:dhaS
Ordered Locus Names:BSU19310
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU19310. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Putative aldehyde dehydrogenase DhaSPRO_0000379509Add
BLAST

Proteomic databases

PaxDbiO34660.
PRIDEiO34660.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU19310.

Structurei

3D structure databases

ProteinModelPortaliO34660.
SMRiO34660. Positions 20-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiO34660.
KOiK00128.
OMAiMACWKMA.
OrthoDBiEOG6BS8QW.
PhylomeDBiO34660.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34660-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLTMQVTK RLETFLQGTK KLYIDGKFVP SASGATFDTP NPATGETLMT
60 70 80 90 100
LYEAQAADVD KAVKAARKAF DQGEWRTMSP ASRSRLMYKL ADLMEEHKTE
110 120 130 140 150
LAQLETLDNG KPINETTNGD IPLAIEHMRY YAGWCTKITG QTIPVSGAYF
160 170 180 190 200
NYTRHEPVGV VGQIIPWNFP LLMAMWKMGA ALATGCTIVL KPAEQTPLSA
210 220 230 240 250
LYLAELIDQA GFPAGVINII PGFGEDAGEA LTNHEAVDKI AFTGSTEIGK
260 270 280 290 300
KIMSTAAKSI KRVTLELGGK SPNILLPDAN LKKAIPGALN GVMFNQGQVC
310 320 330 340 350
CAGSRVFIHK DQYDEVVDEM ASYAESLRQG AGLHKDTQIG PLVSKEQHER
360 370 380 390 400
VLSYIQKGKD EGAKAVTGGS CPFEAGYFVA PTVFANVEDE MTIAKEEIFG
410 420 430 440 450
PVLTAIPYET VDEVIERANH SEYGLAAGLW TENVKQAHYI ADRLQAGTVW
460 470 480 490
VNCYNVFDAA SPFGGYKQSG LGREMGSYAL DNYTEVKSVW VNLED
Length:495
Mass (Da):53,882
Last modified:January 1, 1998 - v1
Checksum:i24EBC782F47034A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027868 Genomic DNA. Translation: AAB84440.1.
AL009126 Genomic DNA. Translation: CAB13823.1.
PIRiH69614.
RefSeqiNP_389813.1. NC_000964.3.
WP_004399332.1. NZ_CM000487.1.

Genome annotation databases

EnsemblBacteriaiCAB13823; CAB13823; BSU19310.
GeneIDi939963.
KEGGibsu:BSU19310.
PATRICi18975713. VBIBacSub10457_2047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027868 Genomic DNA. Translation: AAB84440.1 .
AL009126 Genomic DNA. Translation: CAB13823.1 .
PIRi H69614.
RefSeqi NP_389813.1. NC_000964.3.
WP_004399332.1. NZ_CM000487.1.

3D structure databases

ProteinModelPortali O34660.
SMRi O34660. Positions 20-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU19310.

Proteomic databases

PaxDbi O34660.
PRIDEi O34660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB13823 ; CAB13823 ; BSU19310 .
GeneIDi 939963.
KEGGi bsu:BSU19310.
PATRICi 18975713. VBIBacSub10457_2047.

Organism-specific databases

GenoListi BSU19310. [Micado ]

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
InParanoidi O34660.
KOi K00128.
OMAi MACWKMA.
OrthoDBi EOG6BS8QW.
PhylomeDBi O34660.

Enzyme and pathway databases

BioCyci BSUB:BSU19310-MONOMER.
RETL1328306-WGS:GSTH-4750-MONOMER.
RETL1328306-WGS:GSTH-4814-MONOMER.
RETL1328306-WGS:GSTH-5674-MONOMER.
RETL1328306-WGS:GSTH-6387-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view ]
PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the Bacillus subtilis chromosome region between the terC and odhAB loci cloned in a yeast artificial chromosome."
    Lapidus A., Galleron N., Sorokin A., Ehrlich D.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiALDH4_BACSU
AccessioniPrimary (citable) accession number: O34660
Secondary accession number(s): Q796C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3