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O34660

- ALDH4_BACSU

UniProt

O34660 - ALDH4_BACSU

Protein

Putative aldehyde dehydrogenase DhaS

Gene

dhaS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei266 – 2661PROSITE-ProRule annotation
    Active sitei300 – 3001PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi244 – 2496NADSequence Analysis

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBSUB:BSU19310-MONOMER.
    RETL1328306-WGS:GSTH-4750-MONOMER.
    RETL1328306-WGS:GSTH-4814-MONOMER.
    RETL1328306-WGS:GSTH-5674-MONOMER.
    RETL1328306-WGS:GSTH-6387-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative aldehyde dehydrogenase DhaS (EC:1.2.1.3)
    Gene namesi
    Name:dhaS
    Ordered Locus Names:BSU19310
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU19310. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495Putative aldehyde dehydrogenase DhaSPRO_0000379509Add
    BLAST

    Proteomic databases

    PaxDbiO34660.
    PRIDEiO34660.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU19310.

    Structurei

    3D structure databases

    ProteinModelPortaliO34660.
    SMRiO34660. Positions 20-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00128.
    OMAiMACWKMA.
    OrthoDBiEOG6BS8QW.
    PhylomeDBiO34660.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view]
    PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O34660-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLTMQVTK RLETFLQGTK KLYIDGKFVP SASGATFDTP NPATGETLMT    50
    LYEAQAADVD KAVKAARKAF DQGEWRTMSP ASRSRLMYKL ADLMEEHKTE 100
    LAQLETLDNG KPINETTNGD IPLAIEHMRY YAGWCTKITG QTIPVSGAYF 150
    NYTRHEPVGV VGQIIPWNFP LLMAMWKMGA ALATGCTIVL KPAEQTPLSA 200
    LYLAELIDQA GFPAGVINII PGFGEDAGEA LTNHEAVDKI AFTGSTEIGK 250
    KIMSTAAKSI KRVTLELGGK SPNILLPDAN LKKAIPGALN GVMFNQGQVC 300
    CAGSRVFIHK DQYDEVVDEM ASYAESLRQG AGLHKDTQIG PLVSKEQHER 350
    VLSYIQKGKD EGAKAVTGGS CPFEAGYFVA PTVFANVEDE MTIAKEEIFG 400
    PVLTAIPYET VDEVIERANH SEYGLAAGLW TENVKQAHYI ADRLQAGTVW 450
    VNCYNVFDAA SPFGGYKQSG LGREMGSYAL DNYTEVKSVW VNLED 495
    Length:495
    Mass (Da):53,882
    Last modified:January 1, 1998 - v1
    Checksum:i24EBC782F47034A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027868 Genomic DNA. Translation: AAB84440.1.
    AL009126 Genomic DNA. Translation: CAB13823.1.
    PIRiH69614.
    RefSeqiNP_389813.1. NC_000964.3.
    WP_004399332.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB13823; CAB13823; BSU19310.
    GeneIDi939963.
    KEGGibsu:BSU19310.
    PATRICi18975713. VBIBacSub10457_2047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027868 Genomic DNA. Translation: AAB84440.1 .
    AL009126 Genomic DNA. Translation: CAB13823.1 .
    PIRi H69614.
    RefSeqi NP_389813.1. NC_000964.3.
    WP_004399332.1. NZ_CM000487.1.

    3D structure databases

    ProteinModelPortali O34660.
    SMRi O34660. Positions 20-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU19310.

    Proteomic databases

    PaxDbi O34660.
    PRIDEi O34660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB13823 ; CAB13823 ; BSU19310 .
    GeneIDi 939963.
    KEGGi bsu:BSU19310.
    PATRICi 18975713. VBIBacSub10457_2047.

    Organism-specific databases

    GenoListi BSU19310. [Micado ]

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00128.
    OMAi MACWKMA.
    OrthoDBi EOG6BS8QW.
    PhylomeDBi O34660.

    Enzyme and pathway databases

    BioCyci BSUB:BSU19310-MONOMER.
    RETL1328306-WGS:GSTH-4750-MONOMER.
    RETL1328306-WGS:GSTH-4814-MONOMER.
    RETL1328306-WGS:GSTH-5674-MONOMER.
    RETL1328306-WGS:GSTH-6387-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view ]
    PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the Bacillus subtilis chromosome region between the terC and odhAB loci cloned in a yeast artificial chromosome."
      Lapidus A., Galleron N., Sorokin A., Ehrlich D.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiALDH4_BACSU
    AccessioniPrimary (citable) accession number: O34660
    Secondary accession number(s): Q796C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3