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Protein

CdaA regulatory protein CdaR

Gene

cdaR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Upon coexpression in E.coli stimulates the diadenylate cyclase activity of CdaA about 20-fold (PubMed:23192352). In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess (PubMed:26240071).2 Publications

GO - Biological processi

  • positive regulation of adenylate cyclase activity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciBSUB:BSU01760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
CdaA regulatory protein CdaRCurated
Alternative name(s):
YbbR-like domain-containing protein YbbR
c-di-AMP synthase A regulator1 Publication
Gene namesi
Name:cdaR1 Publication
Synonyms:ybbR
Ordered Locus Names:BSU01760
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2618HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483CdaA regulatory protein CdaRPRO_0000384386Add
BLAST

Proteomic databases

PaxDbiO34659.

Expressioni

Inductioni

Constitutively expressed, part of the cdaA-cdaR-glmM-glmS operon (PubMed:23192352).1 Publication

Interactioni

Subunit structurei

Interacts with CdaA (PubMed:23192352, PubMed:26240071).2 Publications

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001003.

Structurei

3D structure databases

ProteinModelPortaliO34659.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 13581YbbR-like 1Add
BLAST
Domaini143 – 22886YbbR-like 2Add
BLAST
Domaini237 – 31680YbbR-like 3Add
BLAST
Domaini329 – 39466YbbR-like 4Add
BLAST

Sequence similaritiesi

Contains 4 YbbR-like domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107U5W. Bacteria.
COG4856. LUCA.
HOGENOMiHOG000054579.
InParanoidiO34659.
OMAiFEIYADM.
PhylomeDBiO34659.

Family and domain databases

InterProiIPR012505. YbbR.
[Graphical view]
PfamiPF07949. YbbR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKFLNNRWA VKIIALLFAL LLYVAVNSNQ APTPKKPGES FFPTSTTDEA
60 70 80 90 100
TLTDIPVKAY YDDENYVVTG VPQTVNVTIK GSTSAVKKAR QTKNFEIYAD
110 120 130 140 150
MEHLKTGTHK VELKAKNVSD GLTISINPSV TTVTIQERTT KSFPVEVEYY
160 170 180 190 200
NKSKMKKGYS PEQPIVSPKN VQITGSKNVI DNISLVKASV NLENADETIE
210 220 230 240 250
KEAKVTVYDK DGNALPVDVE PSVIKITVPV TSPSKKVPFK IERTGSLPDG
260 270 280 290 300
VSIANIESSP SEVTVYGSQD VLDSLEFIDG VSLDLSKINK DSDIEADIPL
310 320 330 340 350
PDGVKKISPS KVTLHIEVDS EADQKFENVP IKTVGLSSSQ NIEFLDPESQ
360 370 380 390 400
AIDVTAKGSP TNINKLKKSD IELYVNVSDL EDGEHSVKLE VNGPQNVTWS
410 420 430 440 450
LGRKNAKIKL TSKKSNTSTN DNSSNTSGNQ DTDKQTNDQK NNQQEDTKNT
460 470 480
DKNNNDQNQD GNKDQNQDQD EDESTANSQS SSE
Length:483
Mass (Da):52,907
Last modified:May 5, 2009 - v2
Checksum:iC591A9A3106D7BC2
GO

Sequence cautioni

The sequence BAA33068 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti186 – 1861V → H in BAA33068 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006424 Genomic DNA. Translation: BAA33068.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB11952.2.
RefSeqiNP_388057.2. NC_000964.3.
WP_003234947.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB11952; CAB11952; BSU01760.
GeneIDi938867.
KEGGibsu:BSU01760.
PATRICi18971905. VBIBacSub10457_0181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006424 Genomic DNA. Translation: BAA33068.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB11952.2.
RefSeqiNP_388057.2. NC_000964.3.
WP_003234947.1. NZ_JNCM01000030.1.

3D structure databases

ProteinModelPortaliO34659.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001003.

Proteomic databases

PaxDbiO34659.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB11952; CAB11952; BSU01760.
GeneIDi938867.
KEGGibsu:BSU01760.
PATRICi18971905. VBIBacSub10457_0181.

Phylogenomic databases

eggNOGiENOG4107U5W. Bacteria.
COG4856. LUCA.
HOGENOMiHOG000054579.
InParanoidiO34659.
OMAiFEIYADM.
PhylomeDBiO34659.

Enzyme and pathway databases

BioCyciBSUB:BSU01760-MONOMER.

Family and domain databases

InterProiIPR012505. YbbR.
[Graphical view]
PfamiPF07949. YbbR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDAR_BACSU
AccessioniPrimary (citable) accession number: O34659
Secondary accession number(s): O87088
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.