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Protein

Sensor histidine kinase YkoH

Gene

ykoH

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable member of the two-component regulatory system YkoH/YkoG. Potentially phosphorylates YkoG.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU13260-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor histidine kinase YkoH (EC:2.7.13.3)
Gene namesi
Name:ykoH
Ordered Locus Names:BSU13260
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence analysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Topological domaini34 – 153120ExtracellularSequence analysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Topological domaini175 – 454280CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Sensor histidine kinase YkoHPRO_0000074922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei241 – 2411Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO34638.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100007346.

Structurei

3D structure databases

ProteinModelPortaliO34638.
SMRiO34638. Positions 220-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 23055HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini238 – 450213Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41062D9. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000223177.
InParanoidiO34638.
KOiK00936.
OMAiSEFKITI.
PhylomeDBiO34638.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKTKIHLY TSISLLILLI LVHTAVYLIF SSALTSKDAA RLADETDNIA
60 70 80 90 100
EALRAAETEG VALQDMLQAY LPANGMVRVV NGDQKAVMTI TKEKAYKDFP
110 120 130 140 150
LSFHSGETAD VRKPDGKLFA EAAVPVIWTD GQVVSLQLVE RLENTEESLF
160 170 180 190 200
LLKIILIAAS AAVCIASFFA GSLLARRIIN PIRRLMITMK DIQRDKEFKT
210 220 230 240 250
ISLEGQSNDE LYQMGLTFNE MAMMLKEHYD KQQQFVQDAS HELKTPLTII
260 270 280 290 300
ESYSSLMKRW GAKKPEVLEE SIEAIHSEAV HMKKLTNQLL ALAKSHQGLE
310 320 330 340 350
VDLKTIDLIK AARAVMQTLQ SVYQRDILLE TDKESLLVKA DEERIKQLLT
360 370 380 390 400
ILLDNAIKYS EKPIEMSAGT RNGRPFLSVR DEGIGIPEEH IPHLFERFYR
410 420 430 440 450
ADEARNRKTG GTGLGLSIAK QIADEHGIEL SVKSKPGQGT AVTMQFSEQN

GGGR
Length:454
Mass (Da):50,651
Last modified:January 1, 1998 - v1
Checksum:i9F5CFADD0B2B3961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002571 Genomic DNA. Translation: CAA05605.1.
AL009126 Genomic DNA. Translation: CAB13183.1.
PIRiD69859.
RefSeqiNP_389209.1. NC_000964.3.
WP_003245526.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB13183; CAB13183; BSU13260.
GeneIDi936458.
KEGGibsu:BSU13260.
PATRICi18974413. VBIBacSub10457_1399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002571 Genomic DNA. Translation: CAA05605.1.
AL009126 Genomic DNA. Translation: CAB13183.1.
PIRiD69859.
RefSeqiNP_389209.1. NC_000964.3.
WP_003245526.1. NZ_JNCM01000035.1.

3D structure databases

ProteinModelPortaliO34638.
SMRiO34638. Positions 220-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100007346.

Proteomic databases

PaxDbiO34638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13183; CAB13183; BSU13260.
GeneIDi936458.
KEGGibsu:BSU13260.
PATRICi18974413. VBIBacSub10457_1399.

Phylogenomic databases

eggNOGiENOG41062D9. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000223177.
InParanoidiO34638.
KOiK00936.
OMAiSEFKITI.
PhylomeDBiO34638.

Enzyme and pathway databases

BioCyciBSUB:BSU13260-MONOMER.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYKOH_BACSU
AccessioniPrimary (citable) accession number: O34638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.