O34635 (SDHB_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable L-serine dehydratase, beta chain
Short name=SDH
EC=4.3.1.17

Alternative name(s):
L-serine deaminase
Short name=L-SD

Gene names

Name:	sdaAB
Synonyms:	yloW
Ordered Locus Names:	BSU15850

Organism

Bacillus subtilis

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3.
Cofactor	Binds 1 4Fe-4S cluster By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Subunit structure	Heterodimer of an alpha chain and a beta chain By similarity.
Sequence similarities	Belongs to the iron-sulfur dependent L-serine dehydratase family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Gluconeogenesis
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC amino acid binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Probable L-serine dehydratase, beta chain		PRO_0000171916
Regions
	Domain	147 – 218	72	ACT

Sequences

	Sequence		Length	Mass (Da)
	O34635 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 2BDEB5CF70C2D1CD	FASTA	220	23,819
	10 20 30 40 50 60 MKYRSVFDII GPVMIGPSSS HTAGAARIGR VARSLFGREP ERIIVSFYGS FAETYKGHGT 70 80 90 100 110 120 DVAIIGGLLD FDTFDERIKT AIQIAEAKGI DIEFRVEDAV PVHPNTAKIT ISDEKGELEL 130 140 150 160 170 180 TGISIGGGKI EITELNGFEL RLSGNHPAIL VVHNDKFGTI AGVANVLAKF SINVGHMEVA 190 200 210 220 RKDIGQLALM TIEVDQNIDD HILDELSKLP NIIQVTKIAD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 28 kbp segment from the spoVM region of the Bacillus subtilis 168 genome." Foulger D., Errington J. Microbiology 144:801-805(1998) [PubMed: 9534248] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y13937 Genomic DNA. Translation: CAA74258.1. AL009126 Genomic DNA. Translation: CAB13458.1.
PIR	F69879.
RefSeq	NP_389467.1. NC_000964.3.
3D structure databases
ProteinModelPortal	O34635.
SMR	O34635. Positions 19-130, 145-219.
ModBase	Search...
Protein-protein interaction databases
IntAct	O34635. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000003875; EBBACP00000003875; EBBACG00000003867.
GeneID	935964.
GenomeReviews	Gene locus BSU15850 in contig AL009126_GR.
KEGG	bsu:BSU15850.
NMPDR	fig|224308.1.peg.1587.
PATRIC	18974975. VBIBacSub10457_1679.
Organism-specific databases
GenoList	BSU15850. [Micado]
Phylogenomic databases
GeneTree	EBGT00050000001764.
HOGENOM	HBG339819.
OMA	HTAGACR.
PhylomeDB	O34635.
ProtClustDB	CLSK2518229.
Enzyme and pathway databases
BioCyc	BSUB:BSU15850-MONOMER.
Family and domain databases
InterPro	IPR002912. ACT-bd. IPR004643. Fe-S_L-Ser_bsu. IPR005131. Ser_deHydtase_bsu. [Graphical view]
KO	K01752.
Pfam	PF01842. ACT. 1 hit. PF03315. SDH_beta. 1 hit. [Graphical view]
PIRSF	PIRSF036692. SDH_B. 1 hit.
TIGRFAMs	TIGR00719. Sda_beta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SDHB_BACSU

Accession

Primary (citable) accession number: O34635

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program