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Protein

HTH-type transcriptional regulator LmrA

Gene

lmrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as repressor of the lincomycin-resistance (lmrAB) and yxaGH operons.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi27 – 4620H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU02680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator LmrA
Gene namesi
Name:lmrA
Synonyms:yccB
Ordered Locus Names:BSU02680
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188HTH-type transcriptional regulator LmrAPRO_0000360709Add
BLAST

Proteomic databases

PaxDbiO34619.
PRIDEiO34619.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001488.

Structurei

3D structure databases

ProteinModelPortaliO34619.
SMRiO34619. Positions 4-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6461HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105J7D. Bacteria.
ENOG4111TWN. LUCA.
HOGENOMiHOG000161263.
InParanoidiO34619.
KOiK18939.
OMAiEACHEAY.
OrthoDBiEOG6RFZX9.
PhylomeDBiO34619.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYGDSREKI LSAATRLFQL QGYYGTGLNQ IIKESGAPKG SLYYHFPGGK
60 70 80 90 100
EQLAIEAVNE MKEYIRQKIA DCMEACTDPA EGIQAFLKEL SCQFSCTEDI
110 120 130 140 150
EGLPVGLLAA ETSLKSEPLR EACHEAYKEW ASVYEEKLRQ TGCSESRAKE
160 170 180
ASTVVNAMIE GGILLSLTAK NSTPLLHISS CIPDLLKR
Length:188
Mass (Da):20,663
Last modified:January 1, 1998 - v1
Checksum:i2FE6827325231A5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000617 Genomic DNA. Translation: BAA22229.1.
AL009126 Genomic DNA. Translation: CAB12062.1.
PIRiD69652.
RefSeqiNP_388150.1. NC_000964.3.
WP_003246449.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB12062; CAB12062; BSU02680.
GeneIDi938385.
KEGGibsu:BSU02680.
PATRICi18972095. VBIBacSub10457_0276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000617 Genomic DNA. Translation: BAA22229.1.
AL009126 Genomic DNA. Translation: CAB12062.1.
PIRiD69652.
RefSeqiNP_388150.1. NC_000964.3.
WP_003246449.1. NZ_JNCM01000030.1.

3D structure databases

ProteinModelPortaliO34619.
SMRiO34619. Positions 4-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001488.

Proteomic databases

PaxDbiO34619.
PRIDEiO34619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12062; CAB12062; BSU02680.
GeneIDi938385.
KEGGibsu:BSU02680.
PATRICi18972095. VBIBacSub10457_0276.

Phylogenomic databases

eggNOGiENOG4105J7D. Bacteria.
ENOG4111TWN. LUCA.
HOGENOMiHOG000161263.
InParanoidiO34619.
KOiK18939.
OMAiEACHEAY.
OrthoDBiEOG6RFZX9.
PhylomeDBiO34619.

Enzyme and pathway databases

BioCyciBSUB:BSU02680-MONOMER.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A 32 kb nucleotide sequence from the region of the lincomycin-resistance gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and identification of the site of the lin-2 mutation."
    Kumano M., Tamakoshi A., Yamane K.
    Microbiology 143:2775-2782(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Multidrug resistant phenotype of Bacillus subtilis spontaneous mutants isolated in the presence of puromycin and lincomycin."
    Murata M., Ohno S., Kumano M., Yamane K., Ohki R.
    Can. J. Microbiol. 49:71-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Bacillus subtilis LmrA is a repressor of the lmrAB and yxaGH operons: identification of its binding site and functional analysis of lmrB and yxaGH."
    Yoshida K., Ohki Y.-H., Murata M., Kinehara M., Matsuoka H., Satomura T., Ohki R., Kumano M., Yamane K., Fujita Y.
    J. Bacteriol. 186:5640-5648(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: REVIEW, GENE FAMILY.
  6. "Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in response to flavonoids."
    Hirooka K., Kunikane S., Matsuoka H., Yoshida K., Kumamoto K., Tojo S., Fujita Y.
    J. Bacteriol. 189:5170-5182(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLMRA_BACSU
AccessioniPrimary (citable) accession number: O34619
Secondary accession number(s): Q797R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: February 17, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.