Reviewed, UniProtKB/Swiss-Prot O34607 (SDHA_BACSU)

Names and origin

Protein names

Recommended name:
    Probable L-serine dehydratase, alpha chain
      Short name=SDH
    EC=4.3.1.17
Alternative name(s):
    L-serine deaminase
      Short name=L-SD

Gene names

Name:	sdaAA
Synonyms:	ylpA
Ordered Locus Names:	BSU15860

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3.
Cofactor	Binds 1 4Fe-4S cluster By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Subunit structure	Heterodimer of an alpha chain and a beta chain By similarity.
Sequence similarities	Belongs to the iron-sulfur dependent L-serine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Probable L-serine dehydratase, alpha chain		PRO_0000171912

Sequences

	Sequence		Length	Mass (Da)
	O34607-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 244239DA147CB014	FASTA	300	30,936
	10 20 30 40 50 60 MFRNVKELIE ITKEKQILIS DVMIAQEMEV TEKTKEDIFQ QMDHNLSVME AAVQKGLEGV 70 80 90 100 110 120 TSQTGLTGGD AVKLQAYIRS GKSLSGPLIL DAVSKAVATN EVNAAMGTIC ATPTAGSAGV 130 140 150 160 170 180 VPGTLFAVKE KLNPTREQMI RFLFTAGAFG FVVANNASIS GAAGGCQAEV GSASGMAAAA 190 200 210 220 230 240 IVEMAGGTPE QSAEAMAITL KNMLGLVCDP VAGLVEVPCV KRNAMGASNA MIAADMALAG 250 260 270 280 290 300 ITSRIPCDEV IDAMYKIGQT MPTALRETGQ GGLAATPTGR ELEKKIFGGA LGSRETTSAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 28 kbp segment from the spoVM region of the Bacillus subtilis 168 genome." Foulger D., Errington J. Microbiology 144:801-805(1998) [PubMed: 9534248] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y13937 Genomic DNA. Translation: CAA74259.1. AL009126 Genomic DNA. Translation: CAB13459.1.
PIR	G69879.
RefSeq	NP_389468.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	937109.
GenomeReviews	Gene locus BSU15860 in contig AL009126_GR.
KEGG	bsu:BSU15860.
NMPDR	fig|224308.1.peg.1588.
Organism-specific databases
SubtiList	BG13398. sdaAA. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	O34607.
OMA	AIVEMAG.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU1587-MON.
BRENDA	4.3.1.17. 150.
Family and domain databases
InterPro	IPR004642. L-Ser_deHydtase_asu. IPR005130. Ser_deHydtase_asu. [Graphical view]
Pfam	PF03313. SDH_alpha. 1 hit. [Graphical view]
TIGRFAMs	TIGR00718. sda_alpha. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SDHA_BACSU

Accession

Primary (citable) accession number: O34607

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)