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Protein

Biotin carboxylase 2

Gene

accC2

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Catalytic activityi

ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine.
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Biotin carboxylase 2 (accC2), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Biotin carboxylase 1 (accC1), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116ATPBy similarity1
Binding sitei200ATPBy similarity1
Binding sitei235ATPBy similarity1
Active sitei292By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU18240-MONOMER
UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxylase 2 (EC:6.3.4.14)
Alternative name(s):
Acetyl-CoA carboxylase subunit A 2 (EC:6.4.1.2)
Short name:
ACC 2
Gene namesi
Name:accC2
Synonyms:accC, yngH
Ordered Locus Names:BSU18240
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003608411 – 444Biotin carboxylase 2Add BLAST444

Proteomic databases

PaxDbiO34544
PRIDEiO34544

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.By similarity

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010051

Structurei

3D structure databases

ProteinModelPortaliO34544
SMRiO34544
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 444Biotin carboxylationAdd BLAST444
Domaini120 – 317ATP-graspPROSITE-ProRule annotationAdd BLAST198

Phylogenomic databases

eggNOGiENOG4105CER Bacteria
COG0439 LUCA
HOGENOMiHOG000008988
InParanoidiO34544
KOiK01961
OMAiGGNMSIQ
PhylomeDBiO34544

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005481 BC-like_N
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O34544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTKVLIANR GEIAMRIIRT CSRLGIKTVA VYSEADKDAP HTKAATEAYL
60 70 80 90 100
IGESRVSESY LNIERIIKTA KKAKADAIHP GYGLLSENSR FAERCKQENI
110 120 130 140 150
VFIGPSPDII AKMGSKIEAR KAMEAAGVPV VPGVSESLGD IEAACRTASQ
160 170 180 190 200
IGYPVMLKAS AGGGGIGMQR VENEEALKKA YEGNKKRAAD FFGDGSMYIE
210 220 230 240 250
KVIEHARHIE VQLLADQHGH TVHLFERDCS VQRRHQKVIE EAPSPFVDDE
260 270 280 290 300
LRMKIGQTAV KAAKAIGYTN AGTIEFIVDQ KQNFYFLEMN TRLQVEHPVT
310 320 330 340 350
EEITGLDLVE QQLRIAAGHT LTFSQKDIQR NGHAIEVRIY AEDPKTFFPS
360 370 380 390 400
PGTITAFSLP DQKGVRHECA VAKDSTVTPF YDPMIAKMIV KGQTRTEAIE
410 420 430 440
KLETALRDYR VEGIKTNLPL LIQAAATKAF KEGDVTTDFL KQHL
Length:444
Mass (Da):49,087
Last modified:January 1, 1998 - v1
Checksum:iC866DEB8B4177E3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13917 Genomic DNA Translation: CAA74216.1
AL009126 Genomic DNA Translation: CAB13707.1
PIRiE69893
RefSeqiNP_389706.1, NC_000964.3
WP_003231523.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13707; CAB13707; BSU18240
GeneIDi939474
KEGGibsu:BSU18240
PATRICifig|224308.179.peg.1990

Similar proteinsi

Entry informationi

Entry nameiACCC2_BACSU
AccessioniPrimary (citable) accession number: O34544
Secondary accession number(s): Q799L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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