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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.1 Publication

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciBSUB:BSU13010-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Gene namesi
Name:pgl
Synonyms:ykgB
Ordered Locus Names:BSU13010
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570 Componenti: Chromosome

Organism-specific databases

GenoListiBSU13010. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3493496-phosphogluconolactonasePRO_0000171144Add
BLAST

Proteomic databases

PaxDbiO34499.

Interactioni

Protein-protein interaction databases

IntActiO34499. 1 interaction.
MINTiMINT-8367251.
STRINGi224308.BSU13010.

Structurei

3D structure databases

ProteinModelPortaliO34499.
SMRiO34499. Positions 3-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.Curated

Phylogenomic databases

eggNOGiCOG2706.
HOGENOMiHOG000243565.
InParanoidiO34499.
KOiK07404.
OMAiSIMAHEG.
OrthoDBiEOG615VK7.
PhylomeDBiO34499.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011048. Haem_d1.
IPR019405. Lactonase_7-beta_prop.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF51004. SSF51004. 1 hit.

Sequencei

Sequence statusi: Complete.

O34499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKYIGYVGT YTKGGSEGIY SFELDTEKKA LSEPKLAAKL GNPTYVATNK
60 70 80 90 100
NNTILYSIEK ADGQGGVAAY QIDKNSGELT FLNHQLIDGP SPCHVSVDDQ
110 120 130 140 150
NQFVLTANYH SGKVHVFPVQ EDGSLQSPVS EAAHTGKGPH ERQEKPHTHY
160 170 180 190 200
AGFTPEHNYV VAVDLGIDKL YTYKLKDGVL TESGSHSFAP GAGPRHIAFH
210 220 230 240 250
PKEKYAYVMT ELSNEVIALE YNPTAGEFRE IQVVSAIPDD FTDNSQGSAI
260 270 280 290 300
HVTQDGRFVY VANRGHDSIA VFEVNQYSGE LAFVERVSTE GNWPRDFVFD
310 320 330 340
PTEGFLVASN EETGNLVLFE RDKETGRLTL LPSTVSVPYP VCVKFLHQV
Length:349
Mass (Da):38,411
Last modified:January 1, 1998 - v1
Checksum:iB8711D1D523CF5FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002571 Genomic DNA. Translation: CAA05581.1.
AL009126 Genomic DNA. Translation: CAB13158.1.
PIRiD69856.
RefSeqiNP_389184.1. NC_000964.3.
WP_003244689.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB13158; CAB13158; BSU13010.
GeneIDi937980.
KEGGibsu:BSU13010.
PATRICi18974359. VBIBacSub10457_1372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002571 Genomic DNA. Translation: CAA05581.1.
AL009126 Genomic DNA. Translation: CAB13158.1.
PIRiD69856.
RefSeqiNP_389184.1. NC_000964.3.
WP_003244689.1. NZ_JNCM01000035.1.

3D structure databases

ProteinModelPortaliO34499.
SMRiO34499. Positions 3-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO34499. 1 interaction.
MINTiMINT-8367251.
STRINGi224308.BSU13010.

Proteomic databases

PaxDbiO34499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13158; CAB13158; BSU13010.
GeneIDi937980.
KEGGibsu:BSU13010.
PATRICi18974359. VBIBacSub10457_1372.

Organism-specific databases

GenoListiBSU13010. [Micado]

Phylogenomic databases

eggNOGiCOG2706.
HOGENOMiHOG000243565.
InParanoidiO34499.
KOiK07404.
OMAiSIMAHEG.
OrthoDBiEOG615VK7.
PhylomeDBiO34499.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciBSUB:BSU13010-MONOMER.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011048. Haem_d1.
IPR019405. Lactonase_7-beta_prop.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF51004. SSF51004. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the Bacillus subtilis genome between xlyA and ykoR."
    Devine K.M.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Global probabilistic annotation of metabolic networks enables enzyme discovery."
    Plata G., Fuhrer T., Sauer U., Vitkup D.
    Nat. Chem. Biol. 8:848-854(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry namei6PGL_BACSU
AccessioniPrimary (citable) accession number: O34499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.