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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.1 Publication

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).1 Publication
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating (gndA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciBSUB:BSU13010-MONOMER
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase1 Publication (EC:3.1.1.311 Publication)
Gene namesi
Name:pgl
Synonyms:ykgB
Ordered Locus Names:BSU13010
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001711441 – 3496-phosphogluconolactonaseAdd BLAST349

Proteomic databases

PaxDbiO34499
PRIDEiO34499

Interactioni

Protein-protein interaction databases

IntActiO34499, 1 interactor
MINTiO34499
STRINGi224308.Bsubs1_010100007211

Structurei

3D structure databases

ProteinModelPortaliO34499
SMRiO34499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105HHQ Bacteria
COG2706 LUCA
HOGENOMiHOG000243565
InParanoidiO34499
KOiK07404
OMAiEGNWPRD
PhylomeDBiO34499

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR011048 Haem_d1_sf
IPR019405 Lactonase_7-beta_prop
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF51004 SSF51004, 1 hit

Sequencei

Sequence statusi: Complete.

O34499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKYIGYVGT YTKGGSEGIY SFELDTEKKA LSEPKLAAKL GNPTYVATNK
60 70 80 90 100
NNTILYSIEK ADGQGGVAAY QIDKNSGELT FLNHQLIDGP SPCHVSVDDQ
110 120 130 140 150
NQFVLTANYH SGKVHVFPVQ EDGSLQSPVS EAAHTGKGPH ERQEKPHTHY
160 170 180 190 200
AGFTPEHNYV VAVDLGIDKL YTYKLKDGVL TESGSHSFAP GAGPRHIAFH
210 220 230 240 250
PKEKYAYVMT ELSNEVIALE YNPTAGEFRE IQVVSAIPDD FTDNSQGSAI
260 270 280 290 300
HVTQDGRFVY VANRGHDSIA VFEVNQYSGE LAFVERVSTE GNWPRDFVFD
310 320 330 340
PTEGFLVASN EETGNLVLFE RDKETGRLTL LPSTVSVPYP VCVKFLHQV
Length:349
Mass (Da):38,411
Last modified:January 1, 1998 - v1
Checksum:iB8711D1D523CF5FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002571 Genomic DNA Translation: CAA05581.1
AL009126 Genomic DNA Translation: CAB13158.1
PIRiD69856
RefSeqiNP_389184.1, NC_000964.3
WP_003244689.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13158; CAB13158; BSU13010
GeneIDi937980
KEGGibsu:BSU13010
PATRICifig|224308.179.peg.1413

Entry informationi

Entry namei6PGL_BACSU
AccessioniPrimary (citable) accession number: O34499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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