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O34431

- ATCL_BACSU

UniProt

O34431 - ATCL_BACSU

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Protein

Calcium-transporting ATPase

Gene

yloB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi279 – 2791Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi280 – 2801Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi282 – 2821Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi284 – 2841Calcium 2By similarity
Active sitei326 – 32614-aspartylphosphate intermediateBy similarity
Metal bindingi633 – 6331MagnesiumBy similarity
Metal bindingi637 – 6371MagnesiumBy similarity
Metal bindingi699 – 6991Calcium 1By similarity
Metal bindingi702 – 7021Calcium 1By similarity
Metal bindingi727 – 7271Calcium 2By similarity
Metal bindingi730 – 7301Calcium 1By similarity
Metal bindingi731 – 7311Calcium 1By similarity
Metal bindingi731 – 7311Calcium 2By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-transporting ATPase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU15650-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase (EC:3.6.3.8)
Alternative name(s):
Calcium pump
Gene namesi
Name:yloB
Ordered Locus Names:BSU15650
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU15650.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicBy similarityAdd
BLAST
Transmembranei48 – 6821Helical; Name=1By similarityAdd
BLAST
Topological domaini69 – 7810ExtracellularBy similarity
Transmembranei79 – 9921Helical; Name=2By similarityAdd
BLAST
Topological domaini100 – 238139CytoplasmicBy similarityAdd
BLAST
Transmembranei239 – 25820Helical; Name=3By similarityAdd
BLAST
Topological domaini259 – 27012ExtracellularBy similarityAdd
BLAST
Transmembranei271 – 28818Helical; Name=4By similarityAdd
BLAST
Topological domaini289 – 688400CytoplasmicBy similarityAdd
BLAST
Transmembranei689 – 70820Helical; Name=5By similarityAdd
BLAST
Topological domaini709 – 71810ExtracellularBy similarity
Transmembranei719 – 73921Helical; Name=6By similarityAdd
BLAST
Topological domaini740 – 75920CytoplasmicBy similarityAdd
BLAST
Transmembranei760 – 78223Helical; Name=7By similarityAdd
BLAST
Topological domaini783 – 79816ExtracellularBy similarityAdd
BLAST
Transmembranei799 – 81820Helical; Name=8By similarityAdd
BLAST
Topological domaini819 – 83012CytoplasmicBy similarityAdd
BLAST
Transmembranei831 – 84919Helical; Name=9By similarityAdd
BLAST
Topological domaini850 – 86415ExtracellularBy similarityAdd
BLAST
Transmembranei865 – 88521Helical; Name=10By similarityAdd
BLAST
Topological domaini886 – 8905CytoplasmicBy similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Spores are less resistant to heat and germinate at a slower rate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Calcium-transporting ATPasePRO_0000360851Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO34431.

Expressioni

Developmental stagei

Expressed from 4 hours and peaks at 9 hours after onset of sporulation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU15650.

Structurei

3D structure databases

ProteinModelPortaliO34431.
SMRiO34431. Positions 2-890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
HOGENOMiHOG000265621.
InParanoidiO34431.
KOiK01537.
OMAiLWINLIL.
OrthoDBiEOG6HF5WH.
PhylomeDBiO34431.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR005782. ATPase_P-typ_Ca-transp_IIA.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
PR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34431-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFHEMGQTD LLEATNTSMK QGLTEKEVKK RLDKHGPNEL QEGKKTSALL
60 70 80 90 100
LFFAQFKDFM VLVLLAATLI SGFLGEYVDA VAIIAIVFVN GILGFFQERR
110 120 130 140 150
AEQSLQALKE LSTPHVMALR EGSWTKIPSK ELVPGDIVKF TSGDRIGADV
160 170 180 190 200
RIVEARSLEI EESALTGESI PVVKHADKLK KPDVSLGDIT NMAFMGTIVT
210 220 230 240 250
RGSGVGVVVG TGMNTAMGKI ADMLESAGTL STPLQRRLEQ LGKILIVVAL
260 270 280 290 300
LLTVLVVAVG VIQGHDLYSM FLAGVSLAVA AIPEGLPAIV TVALSLGVQR
310 320 330 340 350
MIKQKSIVRK LPAVETLGCA SIICSDKTGT MTQNKMTVTH VWSGGKTWRV
360 370 380 390 400
AGAGYEPKGS FTLNEKEISV NEHKPLQQML LFGALCNNSN IEKRDGEYVL
410 420 430 440 450
DGDPTEGALL TAARKGGFSK EFVESNYRVI EEFPFDSARK MMTVIVENQD
460 470 480 490 500
RKRYIITKGA PDVLMQRSSR IYYDGSAALF SNERKAETEA VLRHLASQAL
510 520 530 540 550
RTIAVAYRPI KAGETPSMEQ AEKDLTMLGL SGIIDPPRPE VRQAIKECRE
560 570 580 590 600
AGIKTVMITG DHVETAKAIA KDLRLLPKSG KIMDGKMLNE LSQEELSHVV
610 620 630 640 650
EDVYVFARVS PEHKLKIVKA YQENGHIVAM TGDGVNDAPA IKQADIGVSM
660 670 680 690 700
GITGTDVAKE ASSLVLVDDN FATIKSAIKE GRNIYENIRK FIRYLLASNV
710 720 730 740 750
GEILVMLFAM LLALPLPLVP IQILWVNLVT DGLPAMALGM DQPEGDVMKR
760 770 780 790 800
KPRHPKEGVF ARKLGWKVVS RGFLIGVATI LAFIIVYHRN PENLAYAQTI
810 820 830 840 850
AFATLVLAQL IHVFDCRSET SVFSRNPFQN LYLIGAVLSS ILLMLVVIYY
860 870 880 890
PPLQPIFHTV AITPGDWMLV IGMSAIPTFL LAGSLLTRKK
Length:890
Mass (Da):97,293
Last modified:January 1, 1998 - v1
Checksum:i43CB25F7A9BA31A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13937 Genomic DNA. Translation: CAA74269.1.
AL009126 Genomic DNA. Translation: CAB13439.1.
PIRiH69877.
RefSeqiNP_389448.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13439; CAB13439; BSU15650.
GeneIDi936954.
KEGGibsu:BSU15650.
PATRICi18974937. VBIBacSub10457_1660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13937 Genomic DNA. Translation: CAA74269.1 .
AL009126 Genomic DNA. Translation: CAB13439.1 .
PIRi H69877.
RefSeqi NP_389448.1. NC_000964.3.

3D structure databases

ProteinModelPortali O34431.
SMRi O34431. Positions 2-890.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU15650.

Proteomic databases

PaxDbi O34431.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB13439 ; CAB13439 ; BSU15650 .
GeneIDi 936954.
KEGGi bsu:BSU15650.
PATRICi 18974937. VBIBacSub10457_1660.

Organism-specific databases

GenoListi BSU15650.

Phylogenomic databases

eggNOGi COG0474.
HOGENOMi HOG000265621.
InParanoidi O34431.
KOi K01537.
OMAi LWINLIL.
OrthoDBi EOG6HF5WH.
PhylomeDBi O34431.

Enzyme and pathway databases

BioCyci BSUB:BSU15650-MONOMER.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR005782. ATPase_P-typ_Ca-transp_IIA.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
PR00120. HATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 28 kbp segment from the spoVM region of the Bacillus subtilis 168 genome."
    Foulger D., Errington J.
    Microbiology 144:801-805(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Expression of a P-type Ca(2+)-transport ATPase in Bacillus subtilis during sporulation."
    Raeymaekers L., Wuytack E., Willems I., Michiels C.W., Wuytack F.
    Cell Calcium 32:93-93(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Strain: 168 / PS832.

Entry informationi

Entry nameiATCL_BACSU
AccessioniPrimary (citable) accession number: O34431
Secondary accession number(s): Q799L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3