ID MAO3_BACSU Reviewed; 566 AA. AC O34389; DT 28-FEB-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 16-JUN-2009, entry version 64. DE RecName: Full=Probable NAD-dependent malic enzyme 3; DE Short=NAD-ME 3; DE EC=1.1.1.38; GN Name=malS; OrderedLocusNames=BSU29880; OS Bacillus subtilis. OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=1423; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=98048467; PubMed=9387221; RA Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.; RT "Sequencing and functional annotation of the Bacillus subtilis genes RT in the 200 kb rrnB-dnaB region."; RL Microbiology 143:3431-3441(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=168; RX MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786; RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., RA Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., RA Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., RA Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., RA Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., RA Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., RA Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., RA Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., RA Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., RA Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., RA Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., RA Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., RA Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., RA Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., RA Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., RA Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., RA Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., RA Yoshikawa H., Danchin A.; RT "The complete genome sequence of the Gram-positive bacterium Bacillus RT subtilis."; RL Nature 390:249-256(1997). CC -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH. CC -!- COFACTOR: Divalent metal cations. Prefers magnesium or manganese CC (By similarity). CC -!- SIMILARITY: Belongs to the malic enzymes family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF008220; AAC00287.1; -; Genomic_DNA. DR EMBL; AL009126; CAB14966.1; -; Genomic_DNA. DR PIR; D69655; D69655. DR RefSeq; NP_390866.1; -. DR HSSP; P40927; 1GQ2. DR GeneID; 938071; -. DR GenomeReviews; AL009126_GR; BSU29880. DR KEGG; bsu:BSU29880; -. DR NMPDR; fig|224308.1.peg.2991; -. DR SubtiList; BG12614; malS. DR HOGENOM; O34389; -. DR OMA; O34389; IQDNNET. DR BioCyc; BSUB224308:BSU2984-MON; -. DR BRENDA; 1.1.1.38; 150. DR GO; GO:0016619; F:malate dehydrogenase (oxaloacetate-decarbox...; IEA:EC. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro. DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR InterPro; IPR015884; Malic_enzyme_CS. DR InterPro; IPR012301; Malic_N. DR InterPro; IPR012302; Malic_NAD_bd. DR InterPro; IPR001891; Malic_OxRdtase. DR InterPro; IPR016040; NAD(P)-bd_dom. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR Pfam; PF00390; malic; 1. DR Pfam; PF03949; Malic_M; 1. DR PRINTS; PR00072; MALOXRDTASE. DR PROSITE; PS00331; MALIC_ENZYMES; 1. PE 3: Inferred from homology; KW Complete proteome; Metal-binding; NAD; Oxidoreductase. FT CHAIN 1 566 Probable NAD-dependent malic enzyme 3. FT /FTId=PRO_0000160210. FT ACT_SITE 105 105 Proton donor (By similarity). FT ACT_SITE 178 178 Proton acceptor (By similarity). FT METAL 249 249 Divalent metal cation (By similarity). FT METAL 250 250 Divalent metal cation (By similarity). FT METAL 273 273 Divalent metal cation (By similarity). FT BINDING 273 273 NAD (By similarity). FT BINDING 423 423 NAD (By similarity). FT SITE 273 273 Important for activity (By similarity). SQ SEQUENCE 566 AA; 62149 MW; 226C658154548270 CRC64; MKQFRVTNEG DIQTTLRGLE VLSVPFLNKG VAFTEEERKE LGLKGFLPPK VLTIDDQAKR AYEQYSAQPD DLSKNVYLTA LHDRNETLFY RLLNDHLGEM LPIVYTPTVG TAIQRYSHEY RKPRGLYLSI DDPDGMKEAF KQYKDQSDTI DLIVATDAEG ILGIGDWGVG GIAISIGKLA VYTAAAGIDP SRVLAVVLDA GTNQESLLND PLYVGNQHSR VRGERYDQFI DDYVALARET FPNALLHWED FGAKNARSIL KRYKDKVCTF NDDIQGTGAV SLAAVLSCAK ASKVPLRDHR VVIFGAGTAG IGIAEQLREA LVREGLSEEE SYKRFWCIDR NGLLTDDMDQ LLDFQKPYAR SADEVKDYQR NGDGGGIDLL EVVRQAKPTI LIGTSTVSGA FTEEIVKEMA SHVKRPAILP MSNPTTLSEA KPEDLIEWTE GRALITTGSP FPPVEYNGVT YHIGQANNAL VFPGLGLGTI VTKSKLITDG MFEACARAIA GMVNVGVPGA PMLPKVEDLR TVSATVAVEV AKTAMKEGVA TEEPEDIIQA VQDAMWYPVY KPIRAI //