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O34354

- UXAB_BACSU

UniProt

O34354 - UXAB_BACSU

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Protein

Altronate oxidoreductase

Gene

uxaB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 3012NADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. tagaturonate reductase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSUB:BSU12380-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Altronate oxidoreductaseUniRule annotation (EC:1.1.1.58UniRule annotation)
Alternative name(s):
Tagaturonate dehydrogenaseUniRule annotation
Tagaturonate reductaseUniRule annotation
Gene namesi
Name:uxaBUniRule annotation
Synonyms:yjmI
Ordered Locus Names:BSU12380
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU12380. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Altronate oxidoreductasePRO_0000170739Add
BLAST

Proteomic databases

PaxDbiO34354.

Expressioni

Inductioni

Induced by galacturonate, repressed by glucose.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU12380.

Structurei

3D structure databases

ProteinModelPortaliO34354.
SMRiO34354. Positions 3-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family. UxaB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000029586.
InParanoidiO34354.
KOiK00041.
OMAiHNTFCST.
OrthoDBiEOG6CVVB8.
PhylomeDBiO34354.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00670. Altron_oxidoreduct.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

O34354-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKLNKNVYD HYTQYPEKIL QFGEGNFLRG FIDWQIDQLN QHTDFNGSVA
60 70 80 90 100
VVQPRGSEKI KRLNEQDGLY TLFLQGMKDG EAVNEHMIIN SISRGIDLFS
110 120 130 140 150
DYEAYKELAS SERLRFIISN TTEAGIVCDE KDRLEDRPQK TFPGKLTAFL
160 170 180 190 200
YFRYQAFKGD QTKGCVLIPC ELIENNGEKL RETVLHYAHL WKLEEGFTQW
210 220 230 240 250
IHEANTFCNS LVDRIVPGFP VDSIDEITAD LGYQDDLIVV GEQYYLWVIE
260 270 280 290 300
GPDWIGKELP FAAAGLHTKI VSDLTPYRTK KVRILNGAHT AMTPVALLYG
310 320 330 340 350
LKTVRDAVEH PEVGRFIREL IDDEILPVLK MEGLSQYADD VLNRFKNPYI
360 370 380 390 400
KHYLESIALN AISKFKTRNL PTLKEYAEQK GQLPERLVFS FSALLYFYHD
410 420 430 440 450
NETLQDDPAV LQFFKEVWCQ EDGDMLRIAS RVLGEQRLWG ADLNEIPKLT
460 470 480
DRVAVYLNHI HELGMQRALE QYCIQGGEVR
Length:480
Mass (Da):55,361
Last modified:January 1, 1998 - v1
Checksum:iDC7DBC8DA500F8D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015825 Genomic DNA. Translation: AAC46334.1.
AL009126 Genomic DNA. Translation: CAB13095.1.
PIRiC69853.
RefSeqiNP_389120.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13095; CAB13095; BSU12380.
GeneIDi936468.
KEGGibsu:BSU12380.
PATRICi18974217. VBIBacSub10457_1301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015825 Genomic DNA. Translation: AAC46334.1 .
AL009126 Genomic DNA. Translation: CAB13095.1 .
PIRi C69853.
RefSeqi NP_389120.1. NC_000964.3.

3D structure databases

ProteinModelPortali O34354.
SMRi O34354. Positions 3-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU12380.

Proteomic databases

PaxDbi O34354.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB13095 ; CAB13095 ; BSU12380 .
GeneIDi 936468.
KEGGi bsu:BSU12380.
PATRICi 18974217. VBIBacSub10457_1301.

Organism-specific databases

GenoListi BSU12380. [Micado ]

Phylogenomic databases

eggNOGi COG0246.
HOGENOMi HOG000029586.
InParanoidi O34354.
KOi K00041.
OMAi HNTFCST.
OrthoDBi EOG6CVVB8.
PhylomeDBi O34354.

Enzyme and pathway databases

UniPathwayi UPA00246 .
BioCyci BSUB:BSU12380-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_00670. Altron_oxidoreduct.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view ]
PRINTSi PR00084. MTLDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 35.7 kb DNA fragment from the Bacillus subtilis chromosome containing a putative 12.3 kb operon involved in hexuronate catabolism and a perfectly symmetrical hypothetical catabolite-responsive element."
    Rivolta C., Soldo B., Lazarevic V., Joris B., Mauel C., Karamata D.
    Microbiology 144:877-884(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROBABLE OPERON STRUCTURE.
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Regulation of hexuronate utilization in Bacillus subtilis."
    Mekjian K.R., Bryan E.M., Beall B.W., Moran C.P. Jr.
    J. Bacteriol. 181:426-433(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE OPERON STRUCTURE, INDUCTION.
    Strain: 168 / MB24.

Entry informationi

Entry nameiUXAB_BACSU
AccessioniPrimary (citable) accession number: O34354
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Member of the exu locus which is required for galacturonate utilization.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3