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O34354

- UXAB_BACSU

UniProt

O34354 - UXAB_BACSU

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Protein
Altronate oxidoreductase
Gene
uxaB, yjmI, BSU12380
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 3012NAD By similarity
Add
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. tagaturonate reductase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBSUB:BSU12380-MONOMER.
    UniPathwayiUPA00246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Altronate oxidoreductase (EC:1.1.1.58)
    Alternative name(s):
    Tagaturonate dehydrogenase
    Tagaturonate reductase
    Gene namesi
    Name:uxaB
    Synonyms:yjmI
    Ordered Locus Names:BSU12380
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU12380. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Altronate oxidoreductaseUniRule annotation
    PRO_0000170739Add
    BLAST

    Proteomic databases

    PaxDbiO34354.

    Expressioni

    Inductioni

    Induced by galacturonate, repressed by glucose Inferred.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU12380.

    Structurei

    3D structure databases

    ProteinModelPortaliO34354.
    SMRiO34354. Positions 3-474.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000029586.
    KOiK00041.
    OMAiHNTFCST.
    OrthoDBiEOG6CVVB8.
    PhylomeDBiO34354.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00670. Altron_oxidoreduct.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O34354-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKLNKNVYD HYTQYPEKIL QFGEGNFLRG FIDWQIDQLN QHTDFNGSVA    50
    VVQPRGSEKI KRLNEQDGLY TLFLQGMKDG EAVNEHMIIN SISRGIDLFS 100
    DYEAYKELAS SERLRFIISN TTEAGIVCDE KDRLEDRPQK TFPGKLTAFL 150
    YFRYQAFKGD QTKGCVLIPC ELIENNGEKL RETVLHYAHL WKLEEGFTQW 200
    IHEANTFCNS LVDRIVPGFP VDSIDEITAD LGYQDDLIVV GEQYYLWVIE 250
    GPDWIGKELP FAAAGLHTKI VSDLTPYRTK KVRILNGAHT AMTPVALLYG 300
    LKTVRDAVEH PEVGRFIREL IDDEILPVLK MEGLSQYADD VLNRFKNPYI 350
    KHYLESIALN AISKFKTRNL PTLKEYAEQK GQLPERLVFS FSALLYFYHD 400
    NETLQDDPAV LQFFKEVWCQ EDGDMLRIAS RVLGEQRLWG ADLNEIPKLT 450
    DRVAVYLNHI HELGMQRALE QYCIQGGEVR 480
    Length:480
    Mass (Da):55,361
    Last modified:January 1, 1998 - v1
    Checksum:iDC7DBC8DA500F8D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF015825 Genomic DNA. Translation: AAC46334.1.
    AL009126 Genomic DNA. Translation: CAB13095.1.
    PIRiC69853.
    RefSeqiNP_389120.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB13095; CAB13095; BSU12380.
    GeneIDi936468.
    KEGGibsu:BSU12380.
    PATRICi18974217. VBIBacSub10457_1301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF015825 Genomic DNA. Translation: AAC46334.1 .
    AL009126 Genomic DNA. Translation: CAB13095.1 .
    PIRi C69853.
    RefSeqi NP_389120.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali O34354.
    SMRi O34354. Positions 3-474.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU12380.

    Proteomic databases

    PaxDbi O34354.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB13095 ; CAB13095 ; BSU12380 .
    GeneIDi 936468.
    KEGGi bsu:BSU12380.
    PATRICi 18974217. VBIBacSub10457_1301.

    Organism-specific databases

    GenoListi BSU12380. [Micado ]

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000029586.
    KOi K00041.
    OMAi HNTFCST.
    OrthoDBi EOG6CVVB8.
    PhylomeDBi O34354.

    Enzyme and pathway databases

    UniPathwayi UPA00246 .
    BioCyci BSUB:BSU12380-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00670. Altron_oxidoreduct.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "A 35.7 kb DNA fragment from the Bacillus subtilis chromosome containing a putative 12.3 kb operon involved in hexuronate catabolism and a perfectly symmetrical hypothetical catabolite-responsive element."
      Rivolta C., Soldo B., Lazarevic V., Joris B., Mauel C., Karamata D.
      Microbiology 144:877-884(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROBABLE OPERON STRUCTURE.
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Regulation of hexuronate utilization in Bacillus subtilis."
      Mekjian K.R., Bryan E.M., Beall B.W., Moran C.P. Jr.
      J. Bacteriol. 181:426-433(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROBABLE OPERON STRUCTURE, INDUCTION.
      Strain: 168 / MB24.

    Entry informationi

    Entry nameiUXAB_BACSU
    AccessioniPrimary (citable) accession number: O34354
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: January 1, 1998
    Last modified: July 9, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Member of the exu locus which is required for galacturonate utilization.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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