O34346 (UXUA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Synonyms:	yjmE
Ordered Locus Names:	BSU12340

Organism

Bacillus subtilis

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Induction	Induced by galacturonate, repressed by glucose Probable. Ref.3
Miscellaneous	Member of the exu locus which is required for galacturonate utilization. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Mannonate dehydratase HAMAP MF_00106		PRO_0000170664

Sequences

	Sequence		Length	Mass (Da)
	O34346 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: BAEA060E1C278CDF	FASTA	359	41,024
	10 20 30 40 50 60 MNMTFRWYGR GNDTVTLEYV KQIPGVKGIV WALHQKPVGD VWEKEEIRAE TEYIQSYGFH 70 80 90 100 110 120 AEVVESVNVH EAIKLGNEER GRYIENYKQT IRNLAGFGVK VICYNFMPVF DWTRTDMFRP 130 140 150 160 170 180 LEDGSTALFF EKAKVESLDP QELIRTVEEA SDMTLPGWEP EKLARIKELF AAYRTVDEEK 190 200 210 220 230 240 LWDNLSFFLQ EILPVAEAYG VQMAIHPDDP PWPIFGLPRI ITGEASYKKL RAISDSPSNC 250 260 270 280 290 300 ITLCTGSMGA NPANDMVEIA KTYAGIAPFS HIRNVKIYEN GDFIETSHLT KDGSINIQGV 310 320 330 340 350 MEELHKQDYE GYVRPDHGRH LWGEQCRPGY GLYDRALGIM YLNGLWDAYE AMAKKEVGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 35.7 kb DNA fragment from the Bacillus subtilis chromosome containing a putative 12.3 kb operon involved in hexuronate catabolism and a perfectly symmetrical hypothetical catabolite-responsive element." Rivolta C., Soldo B., Lazarevic V., Joris B., Mauel C., Karamata D. Microbiology 144:877-884(1998) [PubMed: 9579062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROBABLE OPERON STRUCTURE. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"Regulation of hexuronate utilization in Bacillus subtilis." Mekjian K.R., Bryan E.M., Beall B.W., Moran C.P. Jr. J. Bacteriol. 181:426-433(1999) [PubMed: 9882655] [Abstract] Cited for: PROBABLE OPERON STRUCTURE, INDUCTION. Strain: 168 / MB24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF015825 Genomic DNA. Translation: AAC46330.1. AL009126 Genomic DNA. Translation: CAB13091.1.
PIR	G69852.
RefSeq	NP_389116.1. NC_000964.3.
3D structure databases
ProteinModelPortal	O34346.
SMR	O34346. Positions 1-355.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000002778; EBBACP00000002778; EBBACG00000002773.
GeneID	939409.
GenomeReviews	Gene locus BSU12340 in contig AL009126_GR.
KEGG	bsu:BSU12340.
NMPDR	fig|224308.1.peg.1235.
PATRIC	18974209. VBIBacSub10457_1297.
Organism-specific databases
GenoList	BSU12340. [Micado]
Phylogenomic databases
GeneTree	EBGT00050000001836.
HOGENOM	HBG585927.
OMA	GIVWALH.
PhylomeDB	O34346.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	BSUB:BSU12340-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_BACSU

Accession

Primary (citable) accession number: O34346

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program