ID   SDPC_BACSU              Reviewed;         203 AA.
AC   O34344;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 47.
DE   RecName: Full=Killing factor sdpC;
DE   AltName: Full=Toxic peptide sdpC;
DE   Flags: Precursor;
GN   Name=sdpC; Synonyms=yvaY; OrderedLocusNames=BSU33770;
OS   Bacillus subtilis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RA   Nakamura A., Grau R., Perego M., Hoch J.A.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA   Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA   Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA   Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA   Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA   Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA   Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA   Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA   Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA   Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA   Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA   Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA   Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA   Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA   Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA   Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA   Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA   Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA   Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA   Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA   Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA   Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   PROTEIN SEQUENCE OF 142-169, AND INVOLVEMENT IN THE INDUCTION OF
RP   SDPRI.
RC   STRAIN=168 / PY79;
RX   PubMed=12817086; DOI=10.1126/science.1086462;
RA   Gonzalez-Pastor J.E., Hobbs E.C., Losick R.;
RT   "Cannibalism by sporulating bacteria.";
RL   Science 301:510-513(2003).
RN   [4]
RP   FUNCTION.
RC   STRAIN=168 / PY79;
RX   PubMed=16469701; DOI=10.1016/j.cell.2005.11.041;
RA   Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.;
RT   "A three-protein signaling pathway governing immunity to a bacterial
RT   cannibalism toxin.";
RL   Cell 124:549-559(2006).
RN   [5]
RP   REPRESSION BY ABRB AND ABH.
RX   PubMed=17720793; DOI=10.1128/JB.01081-07;
RA   Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A.,
RA   Le Breton Y.;
RT   "Abh and AbrB control of Bacillus subtilis antimicrobial gene
RT   expression.";
RL   J. Bacteriol. 189:7720-7732(2007).
CC   -!- FUNCTION: Induces the lysis of other B.subtilis cells that have
CC       not entered the sporulation pathway, providing a source of
CC       nutrients to support sporulation. Its maturation is dependent on
CC       sdpA and sdpB. Also functions as a ligand, being able to bind to
CC       sdpI thereby triggering a signal transduction cascade that
CC       protects the cell against the toxic effects of its own sdpC.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: By spo0A during nutrient starvation, through its direct
CC       negative control of abrB. Repressed by abrB during regular growth
CC       when nutrients are plentiful, in association with the
CC       transcriptional repressor abh.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=I'll have you for
CC       supper - Issue 90 of January 2008;
CC       URL="http://www.expasy.org/spotlight/back_issues/sptlt090.shtml";
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DR   EMBL; AB006738; BAA21902.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15382.1; -; Genomic_DNA.
DR   PIR; B70029; B70029.
DR   RefSeq; NP_391257.1; -.
DR   GeneID; 936227; -.
DR   GenomeReviews; AL009126_GR; BSU33770.
DR   KEGG; bsu:BSU33770; -.
DR   NMPDR; fig|224308.1.peg.3383; -.
DR   SubtiList; BG14076; sdpC.
DR   HOGENOM; O34344; -.
DR   BioCyc; BSUB224308:BSU3374-MON; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Secreted; Signal.
FT   SIGNAL        1     32       Potential.
FT   CHAIN        33    203       Killing factor sdpC.
FT                                /FTId=PRO_0000013732.
FT   CONFLICT    161    161       Missing (in Ref. 3; AA sequence).
SQ   SEQUENCE   203 AA;  22221 MW;  4928C22C6AB4BEBC CRC64;
     MKSKLLRLLI VSMVTILVFS LVGLSKESST SAKENHTFSG EDYFRGLLFG QGEVGKLISN
     DLDPKLVKEA NSTEGKKLVN DVVKFIKKDQ PQYMDELKQS IDSKDPKKLI ENMTKADQLI
     QKYAKKNENV KYSSNKVTPS CGLYAVCVAA GYLYVVGVNA VALQTAAAVT TAVWKYVAKY
     SSSASNNSDL EAAAAKTLKL IHQ
//