Reviewed, UniProtKB/Swiss-Prot O34344 (SDPC_BACSU)

Names and origin

Protein names

Recommended name:
    Killing factor sdpC
Alternative name(s):
    Toxic peptide sdpC

Gene names

Name:	sdpC
Synonyms:	yvaY
Ordered Locus Names:	BSU33770

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation. Its maturation is dependent on sdpA and sdpB. Also functions as a ligand, being able to bind to sdpI thereby triggering a signal transduction cascade that protects the cell against the toxic effects of its own sdpC. Ref.4
Subcellular location	Secreted.
Induction	By spo0A during nutrient starvation, through its direct negative control of abrB. Repressed by abrB during regular growth when nutrients are plentiful, in association with the transcriptional repressor abh. Ref.3

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 203	171	Killing factor sdpC		PRO_0000013732
Experimental info
	Sequence conflict	161	1	Missing AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O34344-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 4928C22C6AB4BEBC	FASTA	203	22,221
	10 20 30 40 50 60 MKSKLLRLLI VSMVTILVFS LVGLSKESST SAKENHTFSG EDYFRGLLFG QGEVGKLISN 70 80 90 100 110 120 DLDPKLVKEA NSTEGKKLVN DVVKFIKKDQ PQYMDELKQS IDSKDPKKLI ENMTKADQLI 130 140 150 160 170 180 QKYAKKNENV KYSSNKVTPS CGLYAVCVAA GYLYVVGVNA VALQTAAAVT TAVWKYVAKY 190 200 SSSASNNSDL EAAAAKTLKL IHQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Nakamura A., Grau R., Perego M., Hoch J.A. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / JH642.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"Cannibalism by sporulating bacteria." Gonzalez-Pastor J.E., Hobbs E.C., Losick R. Science 301:510-513(2003) [PubMed: 12817086] [Abstract] Cited for: PROTEIN SEQUENCE OF 142-169, INVOLVEMENT IN THE INDUCTION OF SDPRI. Strain: 168 / PY79.
[4]	"A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin." Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R. Cell 124:549-559(2006) [PubMed: 16469701] [Abstract] Cited for: FUNCTION. Strain: 168 / PY79.
[5]	"Abh and AbrB control of Bacillus subtilis antimicrobial gene expression." Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A., Le Breton Y. J. Bacteriol. 189:7720-7732(2007) [PubMed: 17720793] [Abstract] Cited for: REPRESSION BY ABRB AND ABH.

Web resources

Protein Spotlight

I'll have you for supper - Issue 90 of January 2008

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB006738 Genomic DNA. Translation: BAA21902.1. AL009126 Genomic DNA. Translation: CAB15382.1.
PIR	B70029.
RefSeq	NP_391257.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	936227.
GenomeReviews	Gene locus BSU33770 in contig AL009126_GR.
KEGG	bsu:BSU33770.
NMPDR	fig|224308.1.peg.3383.
Organism-specific databases
SubtiList	BG14076. sdpC. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	O34344.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU3374-MON.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

SDPC_BACSU

Accession

Primary (citable) accession number: O34344

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)