Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O34344

- SDPC_BACSU

UniProt

O34344 - SDPC_BACSU

Protein

Killing factor SdpC

Gene

sdpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation. Its maturation is dependent on SdpA and SdpB. Also functions as a ligand, being able to bind to SdpI thereby triggering a signal transduction cascade that protects the cell against the toxic effects of its own SdpC.1 Publication

    Enzyme and pathway databases

    BioCyciBSUB:BSU33770-MONOMER.

    Protein family/group databases

    TCDBi9.B.139.1.1. the cannabalism toxin sdpc (sdpc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killing factor SdpC
    Alternative name(s):
    Toxic peptide SdpC
    Gene namesi
    Name:sdpC
    Synonyms:yvaY
    Ordered Locus Names:BSU33770
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU33770. [Micado]

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 203171Killing factor SdpCPRO_0000013732Add
    BLAST

    Proteomic databases

    PaxDbiO34344.

    Expressioni

    Inductioni

    By Spo0A during nutrient starvation, through its direct negative control of AbrB. Repressed by AbrB during regular growth when nutrients are plentiful, in association with the transcriptional repressor Abh.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU33770.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG618R3B.

    Family and domain databases

    InterProiIPR023888. Antimicrobial_SdpC.
    [Graphical view]
    TIGRFAMsiTIGR04032. toxin_SdpC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O34344-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSKLLRLLI VSMVTILVFS LVGLSKESST SAKENHTFSG EDYFRGLLFG    50
    QGEVGKLISN DLDPKLVKEA NSTEGKKLVN DVVKFIKKDQ PQYMDELKQS 100
    IDSKDPKKLI ENMTKADQLI QKYAKKNENV KYSSNKVTPS CGLYAVCVAA 150
    GYLYVVGVNA VALQTAAAVT TAVWKYVAKY SSSASNNSDL EAAAAKTLKL 200
    IHQ 203
    Length:203
    Mass (Da):22,221
    Last modified:January 1, 1998 - v1
    Checksum:i4928C22C6AB4BEBC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti161 – 1611Missing AA sequence (PubMed:12817086)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006738 Genomic DNA. Translation: BAA21902.1.
    AL009126 Genomic DNA. Translation: CAB15382.1.
    PIRiB70029.
    RefSeqiNP_391257.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15382; CAB15382; BSU33770.
    GeneIDi936227.
    KEGGibsu:BSU33770.
    PATRICi18978754. VBIBacSub10457_3540.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    I'll have you for supper - Issue 90 of January 2008

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006738 Genomic DNA. Translation: BAA21902.1 .
    AL009126 Genomic DNA. Translation: CAB15382.1 .
    PIRi B70029.
    RefSeqi NP_391257.1. NC_000964.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU33770.

    Protein family/group databases

    TCDBi 9.B.139.1.1. the cannabalism toxin sdpc (sdpc) family.

    Proteomic databases

    PaxDbi O34344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15382 ; CAB15382 ; BSU33770 .
    GeneIDi 936227.
    KEGGi bsu:BSU33770.
    PATRICi 18978754. VBIBacSub10457_3540.

    Organism-specific databases

    GenoListi BSU33770. [Micado ]

    Phylogenomic databases

    OrthoDBi EOG618R3B.

    Enzyme and pathway databases

    BioCyci BSUB:BSU33770-MONOMER.

    Family and domain databases

    InterProi IPR023888. Antimicrobial_SdpC.
    [Graphical view ]
    TIGRFAMsi TIGR04032. toxin_SdpC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Nakamura A., Grau R., Perego M., Hoch J.A.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168 / JH642.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. Cited for: PROTEIN SEQUENCE OF 142-169, INVOLVEMENT IN THE INDUCTION OF SDPRI.
      Strain: 168 / PY79.
    4. "A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin."
      Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.
      Cell 124:549-559(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: 168 / PY79.
    5. "Abh and AbrB control of Bacillus subtilis antimicrobial gene expression."
      Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A., Le Breton Y.
      J. Bacteriol. 189:7720-7732(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REPRESSION BY ABRB AND ABH.

    Entry informationi

    Entry nameiSDPC_BACSU
    AccessioniPrimary (citable) accession number: O34344
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3