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O34344 (SDPC_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killing factor SdpC
Alternative name(s):
Toxic peptide SdpC
Gene names
Name:sdpC
Synonyms:yvaY
Ordered Locus Names:BSU33770
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation. Its maturation is dependent on SdpA and SdpB. Also functions as a ligand, being able to bind to SdpI thereby triggering a signal transduction cascade that protects the cell against the toxic effects of its own SdpC. Ref.4

Subcellular location

Secreted.

Induction

By Spo0A during nutrient starvation, through its direct negative control of AbrB. Repressed by AbrB during regular growth when nutrients are plentiful, in association with the transcriptional repressor Abh. Ref.3

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 203171Killing factor SdpC
PRO_0000013732

Experimental info

Sequence conflict1611Missing AA sequence Ref.3

Sequences

Sequence LengthMass (Da)Tools
O34344 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 4928C22C6AB4BEBC

FASTA20322,221
        10         20         30         40         50         60 
MKSKLLRLLI VSMVTILVFS LVGLSKESST SAKENHTFSG EDYFRGLLFG QGEVGKLISN 

        70         80         90        100        110        120 
DLDPKLVKEA NSTEGKKLVN DVVKFIKKDQ PQYMDELKQS IDSKDPKKLI ENMTKADQLI 

       130        140        150        160        170        180 
QKYAKKNENV KYSSNKVTPS CGLYAVCVAA GYLYVVGVNA VALQTAAAVT TAVWKYVAKY 

       190        200 
SSSASNNSDL EAAAAKTLKL IHQ 

« Hide

References

« Hide 'large scale' references
[1]Nakamura A., Grau R., Perego M., Hoch J.A.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Cannibalism by sporulating bacteria."
Gonzalez-Pastor J.E., Hobbs E.C., Losick R.
Science 301:510-513(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 142-169, INVOLVEMENT IN THE INDUCTION OF SDPRI.
Strain: 168 / PY79.
[4]"A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin."
Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.
Cell 124:549-559(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: 168 / PY79.
[5]"Abh and AbrB control of Bacillus subtilis antimicrobial gene expression."
Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A., Le Breton Y.
J. Bacteriol. 189:7720-7732(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: REPRESSION BY ABRB AND ABH.

Web resources

Protein Spotlight

I'll have you for supper - Issue 90 of January 2008

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006738 Genomic DNA. Translation: BAA21902.1.
AL009126 Genomic DNA. Translation: CAB15382.1.
PIRB70029.
RefSeqNP_391257.1. NC_000964.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU33770.

Protein family/group databases

TCDB9.B.139.1.1. the cannabalism toxin sdpc (sdpc) family.

Proteomic databases

PaxDbO34344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15382; CAB15382; BSU33770.
GeneID936227.
KEGGbsu:BSU33770.
PATRIC18978754. VBIBacSub10457_3540.

Organism-specific databases

GenoListBSU33770. [Micado]

Phylogenomic databases

OrthoDBEOG618R3B.

Enzyme and pathway databases

BioCycBSUB:BSU33770-MONOMER.

Family and domain databases

InterProIPR023888. Antimicrobial_SdpC.
[Graphical view]
TIGRFAMsTIGR04032. toxin_SdpC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSDPC_BACSU
AccessionPrimary (citable) accession number: O34344
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList