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Protein

Killing factor SdpC

Gene

sdpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation. Its maturation is dependent on SdpA and SdpB. Also functions as a ligand, being able to bind to SdpI thereby triggering a signal transduction cascade that protects the cell against the toxic effects of its own SdpC.1 Publication

Enzyme and pathway databases

BioCyciBSUB:BSU33770-MONOMER.

Protein family/group databases

TCDBi9.B.139.1.1. the cannabalism toxin sdpc (sdpc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Killing factor SdpC
Alternative name(s):
Toxic peptide SdpC
Gene namesi
Name:sdpC
Synonyms:yvaY
Ordered Locus Names:BSU33770
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570 Componenti: Chromosome

Organism-specific databases

GenoListiBSU33770. [Micado]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 203171Killing factor SdpCPRO_0000013732Add
BLAST

Proteomic databases

PaxDbiO34344.

Expressioni

Inductioni

By Spo0A during nutrient starvation, through its direct negative control of AbrB. Repressed by AbrB during regular growth when nutrients are plentiful, in association with the transcriptional repressor Abh.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018321.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

OMAiSKLATEM.
OrthoDBiEOG618R3B.

Family and domain databases

InterProiIPR023888. Antimicrobial_SdpC.
[Graphical view]
TIGRFAMsiTIGR04032. toxin_SdpC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O34344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSKLLRLLI VSMVTILVFS LVGLSKESST SAKENHTFSG EDYFRGLLFG
60 70 80 90 100
QGEVGKLISN DLDPKLVKEA NSTEGKKLVN DVVKFIKKDQ PQYMDELKQS
110 120 130 140 150
IDSKDPKKLI ENMTKADQLI QKYAKKNENV KYSSNKVTPS CGLYAVCVAA
160 170 180 190 200
GYLYVVGVNA VALQTAAAVT TAVWKYVAKY SSSASNNSDL EAAAAKTLKL

IHQ
Length:203
Mass (Da):22,221
Last modified:January 1, 1998 - v1
Checksum:i4928C22C6AB4BEBC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611Missing AA sequence (PubMed:12817086).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006738 Genomic DNA. Translation: BAA21902.1.
AL009126 Genomic DNA. Translation: CAB15382.1.
PIRiB70029.
RefSeqiNP_391257.1. NC_000964.3.
WP_003243360.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15382; CAB15382; BSU33770.
GeneIDi936227.
KEGGibsu:BSU33770.
PATRICi18978754. VBIBacSub10457_3540.

Cross-referencesi

Web resourcesi

Protein Spotlight

I'll have you for supper - Issue 90 of January 2008

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006738 Genomic DNA. Translation: BAA21902.1.
AL009126 Genomic DNA. Translation: CAB15382.1.
PIRiB70029.
RefSeqiNP_391257.1. NC_000964.3.
WP_003243360.1. NZ_JNCM01000033.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018321.

Protein family/group databases

TCDBi9.B.139.1.1. the cannabalism toxin sdpc (sdpc) family.

Proteomic databases

PaxDbiO34344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15382; CAB15382; BSU33770.
GeneIDi936227.
KEGGibsu:BSU33770.
PATRICi18978754. VBIBacSub10457_3540.

Organism-specific databases

GenoListiBSU33770. [Micado]

Phylogenomic databases

OMAiSKLATEM.
OrthoDBiEOG618R3B.

Enzyme and pathway databases

BioCyciBSUB:BSU33770-MONOMER.

Family and domain databases

InterProiIPR023888. Antimicrobial_SdpC.
[Graphical view]
TIGRFAMsiTIGR04032. toxin_SdpC. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Nakamura A., Grau R., Perego M., Hoch J.A.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / JH642.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. Cited for: PROTEIN SEQUENCE OF 142-169, INVOLVEMENT IN THE INDUCTION OF SDPRI.
    Strain: 168 / PY79.
  4. "A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin."
    Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.
    Cell 124:549-559(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 168 / PY79.
  5. "Abh and AbrB control of Bacillus subtilis antimicrobial gene expression."
    Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A., Le Breton Y.
    J. Bacteriol. 189:7720-7732(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REPRESSION BY ABRB AND ABH.

Entry informationi

Entry nameiSDPC_BACSU
AccessioniPrimary (citable) accession number: O34344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 1, 1998
Last modified: June 24, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.