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Reviewed, UniProtKB/Swiss-Prot O34344 (SDPC_BACSU)

Last modified June 16, 2009. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Killing factor sdpC
Alternative name(s):
    Toxic peptide sdpC
Gene names
Name: sdpC
Synonyms: yvaY
Ordered Locus Names: BSU33770
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillus

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation. Its maturation is dependent on sdpA and sdpB. Also functions as a ligand, being able to bind to sdpI thereby triggering a signal transduction cascade that protects the cell against the toxic effects of its own sdpC. Ref.4

Subcellular location

Secreted.

Induction

By spo0A during nutrient starvation, through its direct negative control of abrB. Repressed by abrB during regular growth when nutrients are plentiful, in association with the transcriptional repressor abh. Ref.3

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 203171Killing factor sdpC
PRO_0000013732

Experimental info

Sequence conflict1611Missing AA sequence Ref.3

Sequences

Sequence LengthMass (Da)Tools
O34344-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 4928C22C6AB4BEBC

FASTA20322,221
        10         20         30         40         50         60 
MKSKLLRLLI VSMVTILVFS LVGLSKESST SAKENHTFSG EDYFRGLLFG QGEVGKLISN 

        70         80         90        100        110        120 
DLDPKLVKEA NSTEGKKLVN DVVKFIKKDQ PQYMDELKQS IDSKDPKKLI ENMTKADQLI 

       130        140        150        160        170        180 
QKYAKKNENV KYSSNKVTPS CGLYAVCVAA GYLYVVGVNA VALQTAAAVT TAVWKYVAKY 

       190        200 
SSSASNNSDL EAAAAKTLKL IHQ 

« Hide

References

« Hide 'large scale' references
[1]Nakamura A., Grau R., Perego M., Hoch J.A.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Cannibalism by sporulating bacteria."
Gonzalez-Pastor J.E., Hobbs E.C., Losick R.
Science 301:510-513(2003) [PubMed: 12817086] [Abstract]
Cited for: PROTEIN SEQUENCE OF 142-169, INVOLVEMENT IN THE INDUCTION OF SDPRI.
Strain: 168 / PY79.
[4]"A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin."
Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.
Cell 124:549-559(2006) [PubMed: 16469701] [Abstract]
Cited for: FUNCTION.
Strain: 168 / PY79.
[5]"Abh and AbrB control of Bacillus subtilis antimicrobial gene expression."
Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A., Le Breton Y.
J. Bacteriol. 189:7720-7732(2007) [PubMed: 17720793] [Abstract]
Cited for: REPRESSION BY ABRB AND ABH.

Web resources

Protein Spotlight

I'll have you for supper - Issue 90 of January 2008

Cross-references

Sequence databases

AB006738 Genomic DNA. Translation: BAA21902.1.
AL009126 Genomic DNA. Translation: CAB15382.1.
PIRB70029.
RefSeqNP_391257.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID936227.
GenomeReviewsGene locus BSU33770 in contig AL009126_GR.
KEGGbsu:BSU33770.
NMPDRfig|224308.1.peg.3383.

Organism-specific databases

SubtiListBG14076. sdpC. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMO34344.

Enzyme and pathway databases

BioCycBSUB224308:BSU3374-MON.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameSDPC_BACSU
AccessionPrimary (citable) accession number: O34344
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 1, 1998
Last modified: June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents