Reviewed, UniProtKB/Swiss-Prot O34296 (TTUC3_AGRVI)

Names and origin

Protein names

Recommended name:
    Probable tartrate dehydrogenase/decarboxylase ttuC'
      Short name=TDH
    EC=1.1.1.93
    EC=4.1.1.73
Alternative name(s):
    D-malate dehydrogenase [decarboxylating]
    EC=1.1.1.83

Gene names

Name:

ttuC'

Encoded on

Plasmid pTiAB3

Organism

Agrobacterium vitis (Rhizobium vitis)

Taxonomic identifier

373 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Tartrate + NAD+ = oxaloglycolate + NADH. Meso-tartrate + NAD+ = oxaloglycolate + NADH. (R,R)-tartrate + NAD+ = oxaloglycolate + NADH. (R,R)-tartrate = D-glycerate + CO2. (R)-malate + NAD+ = pyruvate + CO2 + NADH.
Pathway	Carbohydrate acid metabolism; tartaric acid degradation; 2-hydroxy-3-oxosuccinic acid from L-tartaric acid: step 1/1. Carbohydrate acid metabolism; tartaric acid degradation; 2-hydroxy-3-oxosuccinic acid from meso-tartaric acid: step 1/1. Carbohydrate acid metabolism; tartaric acid degradation; D-glyceric acid from L-tartaric acid: step 1/1.
Subcellular location	Cytoplasm By similarity.
Induction	By tartrate.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-malate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC NAD or NADH binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro tartrate decarboxylase activity Inferred from electronic annotation. Source: EC tartrate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Probable tartrate dehydrogenase/decarboxylase ttuC'		PRO_0000083815

Sequences

	Sequence		Length	Mass (Da)
	O34296-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 0820225EA131A9FA	FASTA	358	38,760
	10 20 30 40 50 60 MREYKIAAIP ADGIGPEVIA AGLQVLEALE QRSGDFKIHT ETFDWGSDYY KKHGVMMPAD 70 80 90 100 110 120 GLDKLKKFDA IFFGAVGAPD VPDHITLWGL RLPICQGFDQ YANVRPTKIL PGITPPLRNC 130 140 150 160 170 180 GPGDLDWVIV RENSEGEYSG HGGRAHRGLP EEVGTEVAIF TRVGVTRIMR YAFKLAQARP 190 200 210 220 230 240 RKLLTVVTKS NAQRHGMVMW DEIAAEVATE FPDVTWDKML VDAMTVRMTL KPETLDTIVA 250 260 270 280 290 300 TNLHADILSD LAGALAGSLG VAPTANIDPE RRFPSMFEPI HGSAFDITGK GIANPIATFW 310 320 330 340 350 TAAQMLEHLG ERDAAARLMS AVERVTEAGI LTPDVGGTAN TSQVTEAVCN AIAGSNII

References

[1]	Salomone J.-Y., Szegedi E., Cobanov P., Otten L. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AB3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF010263 Genomic DNA. Translation: AAB65748.1.
3D structure databases
HSSP	HSSP built from PDB template 1DR8 based on UniProtKB P00351.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.83. 97084. 1.1.1.93. 97084. 4.1.1.73. 97084.
Family and domain databases
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR011829. TTC_DH. [Graphical view]
Gene3D	G3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHER	PTHR11835. IDH_IMDH_dimeric. 1 hit. PTHR11835:SF8. TTC_DH. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR02089. TTC. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TTUC3_AGRVI

Accession

Primary (citable) accession number: O34296

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)