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Protein

Gluconate 2-dehydrogenase cytochrome c subunit

Gene
N/A
Organism
Pantoea cypripedii (Pectobacterium cypripedii) (Erwinia cypripedii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the heterotrimer that catalyzes the conversion of D-gluconate to 2-dehydro-D-gluconate.

Catalytic activityi

D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor.

Cofactori

pH dependencei

Optimum pH is 5.0.1 Publication

Temperature dependencei

Optimum temperature is 30 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Heme 1 (covalent)PROSITE-ProRule annotation
Binding sitei43 – 431Heme 1 (covalent)PROSITE-ProRule annotation
Metal bindingi44 – 441Iron (heme 1 axial ligand)PROSITE-ProRule annotation
Binding sitei188 – 1881Heme 2 (covalent)PROSITE-ProRule annotation
Binding sitei191 – 1911Heme 2 (covalent)PROSITE-ProRule annotation
Metal bindingi192 – 1921Iron (heme 2 axial ligand)PROSITE-ProRule annotation
Binding sitei325 – 3251Heme 3 (covalent)PROSITE-ProRule annotation
Binding sitei328 – 3281Heme 3 (covalent)PROSITE-ProRule annotation
Metal bindingi329 – 3291Iron (heme 3 axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18006.
RETL1328306-WGS:GSTH-4491-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Gluconate 2-dehydrogenase cytochrome c subunit (EC:1.1.99.3)
Short name:
GA 2-DH cytochrome c subunit
Short name:
GADH cytochrome c subunit
OrganismiPantoea cypripedii (Pectobacterium cypripedii) (Erwinia cypripedii)
Taxonomic identifieri55209 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePantoea

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 441422Gluconate 2-dehydrogenase cytochrome c subunitPRO_0000045855Add
BLAST

Post-translational modificationi

Binds 3 heme groups per subunit.Curated

Interactioni

Subunit structurei

Heterotrimer.

Structurei

3D structure databases

ProteinModelPortaliO34215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 129104Cytochrome c 1PROSITE-ProRule annotationAdd
BLAST
Domaini173 – 289117Cytochrome c 2PROSITE-ProRule annotationAdd
BLAST
Domaini312 – 40392Cytochrome c 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 cytochrome c domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR009056. Cyt_c-like_dom.
IPR008168. Cyt_C_IC.
IPR014353. Membr-bd_ADH_cyt_c.
[Graphical view]
PfamiPF00034. Cytochrom_C. 1 hit.
PF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
PIRSFiPIRSF000018. Mb_ADH_cyt_c. 1 hit.
PRINTSiPR00605. CYTCHROMECIC.
SUPFAMiSSF46626. SSF46626. 3 hits.
PROSITEiPS51007. CYTC. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O34215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSILALVL GTLSFAALAD DQANDALVKR GEYLARAGDC VACHSVKGGQ
60 70 80 90 100
PFAGGLPMAT PIGTIYSTNI TPDKTTGIGD YSYDDFQKAV RHGVAKNGDT
110 120 130 140 150
LYPAMPYPSY AVVSDEDMKA LYAYFMHGVA PVAQANKDSD IPWPLSMRWP
160 170 180 190 200
LAIWRGVFAP DVKAFQPAAQ EDPVLARGRY LVEGLGHCGA CHTPRSITMQ
210 220 230 240 250
EKALSNDGAH DYLSGSSAPI DGWTASNLRG DNRDGLGRWS EDDLRQFLRY
260 270 280 290 300
GRNDHTAAFG GMTDVVEHSL QHLSDDDITA IARYLKSLGA KDASQTVFTQ
310 320 330 340 350
DDQVAKALWK GDDSQTGASV YVDSCAACHK TDGSRLSALL PGAAWQPGGA
360 370 380 390 400
GEPDPTSLIH IVLTGGTLPG VQGAPTAITM PAFGWRLNDQ QVADVVNFIR
410 420 430 440
GSWGNGAKAT VTAKDVASLR KDETVQAHQG NADIKVLEQQ Q
Length:441
Mass (Da):47,097
Last modified:January 1, 1998 - v1
Checksum:i0AF512CFA99DA123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97665 Genomic DNA. Translation: AAC45884.1.
PIRiC38575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97665 Genomic DNA. Translation: AAC45884.1.
PIRiC38575.

3D structure databases

ProteinModelPortaliO34215.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18006.
RETL1328306-WGS:GSTH-4491-MONOMER.

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR009056. Cyt_c-like_dom.
IPR008168. Cyt_C_IC.
IPR014353. Membr-bd_ADH_cyt_c.
[Graphical view]
PfamiPF00034. Cytochrom_C. 1 hit.
PF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
PIRSFiPIRSF000018. Mb_ADH_cyt_c. 1 hit.
PRINTSiPR00605. CYTCHROMECIC.
SUPFAMiSSF46626. SSF46626. 3 hits.
PROSITEiPS51007. CYTC. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGADH2_PANCY
AccessioniPrimary (citable) accession number: O34215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.