O34111 (O34111_HELPX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Vacuolating cytotoxin EMBL AAC77452.1

Gene names

Name:

vacA EMBL AAC77452.1

Organism

Helicobacter pylori (Campylobacter pylori) EMBL AAC77452.1

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	1290 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities

Contains 1 autotransporter (TC 1.B.12) domain. [View classification] SAAS SAAS005546

Ontologies

Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro outer membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O34111 [UniParc]. Last modified May 1, 1999. Version 2. Checksum: CDA478D88AF30E67	FASTA	1,290	139,322
	10 20 30 40 50 60 MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT GTAVGTVSGL 70 80 90 100 110 120 LSWGLKQAEE ANKTPDKPDK VWRIQAGKGF NEFPNKEYDL YRSLLSSKID GGWDWGNAAR 130 140 150 160 170 180 HYWVKGGQQN KLEVDMKDAV GTYKLSGLRN FTGGDLDVNM QKATLRLGQF NGNSFTSYKD 190 200 210 220 230 240 SADRTTRVNF NAKNISIDNF LEINNRVGSG AGRKASSTVL TLQASEGITS GKNAEISLYD 250 260 270 280 290 300 GATLNLASNS VKLMGNVLMG RLQYVGAYLA PSYSTINTSK VVGEVNFNHL TVGDRNAAQA 310 320 330 340 350 360 GIIASKKTYI GTLDLWQSAG LNIIAPPEGG YKDKPNNTNS QSVGKSDKNE SAKNDKQDSN 370 380 390 400 410 420 TQVINPPNSG QKTEIQPTQV IDGPFAGAKD TVVNINRINT NADGTIRVGG YTASLTTNAA 430 440 450 460 470 480 HLHIGKGGVN LSNQASGRSL LVENLTGNIT VDGPLRVNNQ VGGYALAGSS ANFEFKAGTD 490 500 510 520 530 540 TKNGTATFNN DISLRRFVNL KVDAHTANFK GIDTGNGGFN TLDFSGVTGK VNINKLITAS 550 560 570 580 590 600 TNVAVKNFNI NELIVKTNGV SVGEYTHFSE DIGSQSRINT VRLETGTRSI YSGGVKFKGG 610 620 630 640 650 660 EKLVINDFYY APWNYFDARN IKNVEITNKL AFGPQGSPWG TSKLMFNNLT LGPNAVMDYS 670 680 690 700 710 720 QFSNVTIQGN FINNQGTINY LVRGGKVATL NVGNAAAMMF NNDIDSATGF YKPLIKINSA 730 740 750 760 770 780 QDLIKNTEHV LLKAKIIGYG NVSTGTNGIS NVNLEEQFKE RLALYNNNNR MDTCVVRNTD 790 800 810 820 830 840 DIKACGMAIG NQSMVNNPDN YKYLIGKAWR NIGISKTANG SKISVYYLGN STPTENGGNT 850 860 870 880 890 900 TNLPTNTTNN ARSANYALVK NAPFAHSATP NLVAINQHDF GTIESVFELA NRSKDIDTLY 910 920 930 940 950 960 THSGAQGRDL LQTLLIDSHD AGYARQMIDN TSTGEITKQL NAATDALNNI ASLEHKTSGL 970 980 990 1000 1010 1020 QTLSLSNAMI LNSRLVNLSR RHTNNIDSFA RRLQALKDQR FASLESAAEV LYQFAPKYEK 1030 1040 1050 1060 1070 1080 PTNVWANAIG GASLNSGGNT SLYGTSAGVD AYLNEKVEAI VGGFGSYGYS SFNNQANSLN 1090 1100 1110 1120 1130 1140 SGANNANFGV YSRIFANRHE FDFEAQGAVG SDQSSLNFKS ALLQDLNQSY NYLAYSAATR 1150 1160 1170 1180 1190 1200 ASYGYDFAFF RNALVLKPSV GVSYNHLGST NFESNSTNKT ALKNGASSQH LFNASANVEA 1210 1220 1230 1240 1250 1260 RYYYGDTSYF YMNAGVLQEF ANFGSSNAVS LNTFKVNAAR NPLNTHARVM MGGELKLAKE 1270 1280 1290 VFLNLGFVYL HNLISNIGHF ASNLGMRYSF

References

[1]	"Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan." Ito Y., Azuma T., Ito S., Miyaji H., Hirai M., Yamazaki Y., Sato F., Kato T., Kohli Y., Kuriyama M. J. Clin. Microbiol. 35:1710-1714(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: F79 EMBL AAC77452.1.
[2]	"Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori." Ito Y., Azuma T., Ito S., Suto H., Miyaji H., Yamazaki Y., Kohli Y., Kuriyama M. J. Infect. Dis. 178:1391-1398(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: F79 EMBL AAC77452.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF071097 Genomic DNA. Translation: AAC77452.1.
3D structure databases
ProteinModelPortal	O34111.
SMR	O34111. Positions 391-847.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005546. Auto_transptbeta. IPR006315. OM_autotransptr_brl. IPR003842. Vacuolating_cytotoxin. [Graphical view]
Pfam	PF02691. VacA. 1 hit. [Graphical view]
PRINTS	PR01656. VACCYTOTOXIN.
SMART	SM00869. Autotransporter. 1 hit. [Graphical view]
SUPFAM	SSF103515. Auto_transptbeta. 1 hit.
TIGRFAMs	TIGR01414. autotrans_barl. 1 hit.
PROSITE	PS51208. AUTOTRANSPORTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O34111_HELPX

Accession

Primary (citable) accession number: O34111

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)