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O34111

- O34111_HELPX

UniProt

O34111 - O34111_HELPX

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Protein
Submitted name: Vacuolating cytotoxin
Gene
vacA
Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. outer membrane Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliO34111.
SMRiO34111. Positions 391-847.

Family & Domainsi

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34111-1 [UniParc]FASTAAdd to Basket

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MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT     50
GTAVGTVSGL LSWGLKQAEE ANKTPDKPDK VWRIQAGKGF NEFPNKEYDL 100
YRSLLSSKID GGWDWGNAAR HYWVKGGQQN KLEVDMKDAV GTYKLSGLRN 150
FTGGDLDVNM QKATLRLGQF NGNSFTSYKD SADRTTRVNF NAKNISIDNF 200
LEINNRVGSG AGRKASSTVL TLQASEGITS GKNAEISLYD GATLNLASNS 250
VKLMGNVLMG RLQYVGAYLA PSYSTINTSK VVGEVNFNHL TVGDRNAAQA 300
GIIASKKTYI GTLDLWQSAG LNIIAPPEGG YKDKPNNTNS QSVGKSDKNE 350
SAKNDKQDSN TQVINPPNSG QKTEIQPTQV IDGPFAGAKD TVVNINRINT 400
NADGTIRVGG YTASLTTNAA HLHIGKGGVN LSNQASGRSL LVENLTGNIT 450
VDGPLRVNNQ VGGYALAGSS ANFEFKAGTD TKNGTATFNN DISLRRFVNL 500
KVDAHTANFK GIDTGNGGFN TLDFSGVTGK VNINKLITAS TNVAVKNFNI 550
NELIVKTNGV SVGEYTHFSE DIGSQSRINT VRLETGTRSI YSGGVKFKGG 600
EKLVINDFYY APWNYFDARN IKNVEITNKL AFGPQGSPWG TSKLMFNNLT 650
LGPNAVMDYS QFSNVTIQGN FINNQGTINY LVRGGKVATL NVGNAAAMMF 700
NNDIDSATGF YKPLIKINSA QDLIKNTEHV LLKAKIIGYG NVSTGTNGIS 750
NVNLEEQFKE RLALYNNNNR MDTCVVRNTD DIKACGMAIG NQSMVNNPDN 800
YKYLIGKAWR NIGISKTANG SKISVYYLGN STPTENGGNT TNLPTNTTNN 850
ARSANYALVK NAPFAHSATP NLVAINQHDF GTIESVFELA NRSKDIDTLY 900
THSGAQGRDL LQTLLIDSHD AGYARQMIDN TSTGEITKQL NAATDALNNI 950
ASLEHKTSGL QTLSLSNAMI LNSRLVNLSR RHTNNIDSFA RRLQALKDQR 1000
FASLESAAEV LYQFAPKYEK PTNVWANAIG GASLNSGGNT SLYGTSAGVD 1050
AYLNEKVEAI VGGFGSYGYS SFNNQANSLN SGANNANFGV YSRIFANRHE 1100
FDFEAQGAVG SDQSSLNFKS ALLQDLNQSY NYLAYSAATR ASYGYDFAFF 1150
RNALVLKPSV GVSYNHLGST NFESNSTNKT ALKNGASSQH LFNASANVEA 1200
RYYYGDTSYF YMNAGVLQEF ANFGSSNAVS LNTFKVNAAR NPLNTHARVM 1250
MGGELKLAKE VFLNLGFVYL HNLISNIGHF ASNLGMRYSF 1290
Length:1,290
Mass (Da):139,322
Last modified:May 1, 1999 - v2
Checksum:iCDA478D88AF30E67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071097 Genomic DNA. Translation: AAC77452.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071097 Genomic DNA. Translation: AAC77452.1 .

3D structure databases

ProteinModelPortali O34111.
SMRi O34111. Positions 391-847.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.128.130. 1 hit.
InterProi IPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view ]
Pfami PF02691. VacA. 1 hit.
[Graphical view ]
PRINTSi PR01656. VACCYTOTOXIN.
SMARTi SM00869. Autotransporter. 1 hit.
[Graphical view ]
SUPFAMi SSF103515. SSF103515. 1 hit.
TIGRFAMsi TIGR01414. autotrans_barl. 1 hit.
PROSITEi PS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan."
    Ito Y., Azuma T., Ito S., Miyaji H., Hirai M., Yamazaki Y., Sato F., Kato T., Kohli Y., Kuriyama M.
    J. Clin. Microbiol. 35:1710-1714(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F79Imported.
  2. "Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori."
    Ito Y., Azuma T., Ito S., Suto H., Miyaji H., Yamazaki Y., Kohli Y., Kuriyama M.
    J. Infect. Dis. 178:1391-1398(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F79Imported.

Entry informationi

Entry nameiO34111_HELPX
AccessioniPrimary (citable) accession number: O34111
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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