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Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. outer membrane Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliO34111.
SMRiO34111. Positions 391-847.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34111-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT
60 70 80 90 100
GTAVGTVSGL LSWGLKQAEE ANKTPDKPDK VWRIQAGKGF NEFPNKEYDL
110 120 130 140 150
YRSLLSSKID GGWDWGNAAR HYWVKGGQQN KLEVDMKDAV GTYKLSGLRN
160 170 180 190 200
FTGGDLDVNM QKATLRLGQF NGNSFTSYKD SADRTTRVNF NAKNISIDNF
210 220 230 240 250
LEINNRVGSG AGRKASSTVL TLQASEGITS GKNAEISLYD GATLNLASNS
260 270 280 290 300
VKLMGNVLMG RLQYVGAYLA PSYSTINTSK VVGEVNFNHL TVGDRNAAQA
310 320 330 340 350
GIIASKKTYI GTLDLWQSAG LNIIAPPEGG YKDKPNNTNS QSVGKSDKNE
360 370 380 390 400
SAKNDKQDSN TQVINPPNSG QKTEIQPTQV IDGPFAGAKD TVVNINRINT
410 420 430 440 450
NADGTIRVGG YTASLTTNAA HLHIGKGGVN LSNQASGRSL LVENLTGNIT
460 470 480 490 500
VDGPLRVNNQ VGGYALAGSS ANFEFKAGTD TKNGTATFNN DISLRRFVNL
510 520 530 540 550
KVDAHTANFK GIDTGNGGFN TLDFSGVTGK VNINKLITAS TNVAVKNFNI
560 570 580 590 600
NELIVKTNGV SVGEYTHFSE DIGSQSRINT VRLETGTRSI YSGGVKFKGG
610 620 630 640 650
EKLVINDFYY APWNYFDARN IKNVEITNKL AFGPQGSPWG TSKLMFNNLT
660 670 680 690 700
LGPNAVMDYS QFSNVTIQGN FINNQGTINY LVRGGKVATL NVGNAAAMMF
710 720 730 740 750
NNDIDSATGF YKPLIKINSA QDLIKNTEHV LLKAKIIGYG NVSTGTNGIS
760 770 780 790 800
NVNLEEQFKE RLALYNNNNR MDTCVVRNTD DIKACGMAIG NQSMVNNPDN
810 820 830 840 850
YKYLIGKAWR NIGISKTANG SKISVYYLGN STPTENGGNT TNLPTNTTNN
860 870 880 890 900
ARSANYALVK NAPFAHSATP NLVAINQHDF GTIESVFELA NRSKDIDTLY
910 920 930 940 950
THSGAQGRDL LQTLLIDSHD AGYARQMIDN TSTGEITKQL NAATDALNNI
960 970 980 990 1000
ASLEHKTSGL QTLSLSNAMI LNSRLVNLSR RHTNNIDSFA RRLQALKDQR
1010 1020 1030 1040 1050
FASLESAAEV LYQFAPKYEK PTNVWANAIG GASLNSGGNT SLYGTSAGVD
1060 1070 1080 1090 1100
AYLNEKVEAI VGGFGSYGYS SFNNQANSLN SGANNANFGV YSRIFANRHE
1110 1120 1130 1140 1150
FDFEAQGAVG SDQSSLNFKS ALLQDLNQSY NYLAYSAATR ASYGYDFAFF
1160 1170 1180 1190 1200
RNALVLKPSV GVSYNHLGST NFESNSTNKT ALKNGASSQH LFNASANVEA
1210 1220 1230 1240 1250
RYYYGDTSYF YMNAGVLQEF ANFGSSNAVS LNTFKVNAAR NPLNTHARVM
1260 1270 1280 1290
MGGELKLAKE VFLNLGFVYL HNLISNIGHF ASNLGMRYSF
Length:1,290
Mass (Da):139,322
Last modified:May 1, 1999 - v2
Checksum:iCDA478D88AF30E67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071097 Genomic DNA. Translation: AAC77452.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071097 Genomic DNA. Translation: AAC77452.1.

3D structure databases

ProteinModelPortaliO34111.
SMRiO34111. Positions 391-847.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan."
    Ito Y., Azuma T., Ito S., Miyaji H., Hirai M., Yamazaki Y., Sato F., Kato T., Kohli Y., Kuriyama M.
    J. Clin. Microbiol. 35:1710-1714(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F79Imported.
  2. "Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori."
    Ito Y., Azuma T., Ito S., Suto H., Miyaji H., Yamazaki Y., Kohli Y., Kuriyama M.
    J. Infect. Dis. 178:1391-1398(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F79Imported.

Entry informationi

Entry nameiO34111_HELPX
AccessioniPrimary (citable) accession number: O34111
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.