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O34111

- O34111_HELPX

UniProt

O34111 - O34111_HELPX

Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 2 (01 May 1999)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Vacuolating cytotoxinImported
    Gene namesi
    Name:vacAImported
    OrganismiHelicobacter pylori (Campylobacter pylori)Imported
    Taxonomic identifieri210 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. outer membrane Source: InterPro

    Structurei

    3D structure databases

    ProteinModelPortaliO34111.
    SMRiO34111. Positions 391-847.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di2.40.128.130. 1 hit.
    InterProiIPR005546. Auto_transptbeta.
    IPR006315. OM_autotransptr_brl.
    IPR003842. Vacuolating_cytotoxin.
    [Graphical view]
    PfamiPF02691. VacA. 1 hit.
    [Graphical view]
    PRINTSiPR01656. VACCYTOTOXIN.
    SMARTiSM00869. Autotransporter. 1 hit.
    [Graphical view]
    SUPFAMiSSF103515. SSF103515. 1 hit.
    TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
    PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O34111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT     50
    GTAVGTVSGL LSWGLKQAEE ANKTPDKPDK VWRIQAGKGF NEFPNKEYDL 100
    YRSLLSSKID GGWDWGNAAR HYWVKGGQQN KLEVDMKDAV GTYKLSGLRN 150
    FTGGDLDVNM QKATLRLGQF NGNSFTSYKD SADRTTRVNF NAKNISIDNF 200
    LEINNRVGSG AGRKASSTVL TLQASEGITS GKNAEISLYD GATLNLASNS 250
    VKLMGNVLMG RLQYVGAYLA PSYSTINTSK VVGEVNFNHL TVGDRNAAQA 300
    GIIASKKTYI GTLDLWQSAG LNIIAPPEGG YKDKPNNTNS QSVGKSDKNE 350
    SAKNDKQDSN TQVINPPNSG QKTEIQPTQV IDGPFAGAKD TVVNINRINT 400
    NADGTIRVGG YTASLTTNAA HLHIGKGGVN LSNQASGRSL LVENLTGNIT 450
    VDGPLRVNNQ VGGYALAGSS ANFEFKAGTD TKNGTATFNN DISLRRFVNL 500
    KVDAHTANFK GIDTGNGGFN TLDFSGVTGK VNINKLITAS TNVAVKNFNI 550
    NELIVKTNGV SVGEYTHFSE DIGSQSRINT VRLETGTRSI YSGGVKFKGG 600
    EKLVINDFYY APWNYFDARN IKNVEITNKL AFGPQGSPWG TSKLMFNNLT 650
    LGPNAVMDYS QFSNVTIQGN FINNQGTINY LVRGGKVATL NVGNAAAMMF 700
    NNDIDSATGF YKPLIKINSA QDLIKNTEHV LLKAKIIGYG NVSTGTNGIS 750
    NVNLEEQFKE RLALYNNNNR MDTCVVRNTD DIKACGMAIG NQSMVNNPDN 800
    YKYLIGKAWR NIGISKTANG SKISVYYLGN STPTENGGNT TNLPTNTTNN 850
    ARSANYALVK NAPFAHSATP NLVAINQHDF GTIESVFELA NRSKDIDTLY 900
    THSGAQGRDL LQTLLIDSHD AGYARQMIDN TSTGEITKQL NAATDALNNI 950
    ASLEHKTSGL QTLSLSNAMI LNSRLVNLSR RHTNNIDSFA RRLQALKDQR 1000
    FASLESAAEV LYQFAPKYEK PTNVWANAIG GASLNSGGNT SLYGTSAGVD 1050
    AYLNEKVEAI VGGFGSYGYS SFNNQANSLN SGANNANFGV YSRIFANRHE 1100
    FDFEAQGAVG SDQSSLNFKS ALLQDLNQSY NYLAYSAATR ASYGYDFAFF 1150
    RNALVLKPSV GVSYNHLGST NFESNSTNKT ALKNGASSQH LFNASANVEA 1200
    RYYYGDTSYF YMNAGVLQEF ANFGSSNAVS LNTFKVNAAR NPLNTHARVM 1250
    MGGELKLAKE VFLNLGFVYL HNLISNIGHF ASNLGMRYSF 1290
    Length:1,290
    Mass (Da):139,322
    Last modified:May 1, 1999 - v2
    Checksum:iCDA478D88AF30E67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071097 Genomic DNA. Translation: AAC77452.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071097 Genomic DNA. Translation: AAC77452.1 .

    3D structure databases

    ProteinModelPortali O34111.
    SMRi O34111. Positions 391-847.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.40.128.130. 1 hit.
    InterProi IPR005546. Auto_transptbeta.
    IPR006315. OM_autotransptr_brl.
    IPR003842. Vacuolating_cytotoxin.
    [Graphical view ]
    Pfami PF02691. VacA. 1 hit.
    [Graphical view ]
    PRINTSi PR01656. VACCYTOTOXIN.
    SMARTi SM00869. Autotransporter. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103515. SSF103515. 1 hit.
    TIGRFAMsi TIGR01414. autotrans_barl. 1 hit.
    PROSITEi PS51208. AUTOTRANSPORTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan."
      Ito Y., Azuma T., Ito S., Miyaji H., Hirai M., Yamazaki Y., Sato F., Kato T., Kohli Y., Kuriyama M.
      J. Clin. Microbiol. 35:1710-1714(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: F79Imported.
    2. "Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori."
      Ito Y., Azuma T., Ito S., Suto H., Miyaji H., Yamazaki Y., Kohli Y., Kuriyama M.
      J. Infect. Dis. 178:1391-1398(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: F79Imported.

    Entry informationi

    Entry nameiO34111_HELPX
    AccessioniPrimary (citable) accession number: O34111
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 44 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)