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Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 12951262Sequence analysisPRO_5004158828Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO34110.
SMRiO34110. Positions 396-852.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1022 – 1295274Autotransporter (TC 1.B.12)InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT
60 70 80 90 100
GTAVGTVSGL LSWGLKQAEE ANKTPDKPDK VWRIQAGKGF NEFPNKEYDL
110 120 130 140 150
YRSLLSSKID GGWDWGNAAR HYWVKGGQQN KLEVDMKDAV GTYKLSGLRN
160 170 180 190 200
FTGGDLDVNM QKATLRLGQF NGNSFTSYKD SADRTTRVNF NAKNISIDNF
210 220 230 240 250
VEINNRVGSG AGRKASSTVL TLQASEGITS SKNAEISLYD GATLNLASNS
260 270 280 290 300
VKLNGNVWMG RLQYVGAYLA PSYSTINTSK VTGEVDFNHL TVGDKNAAQA
310 320 330 340 350
GIIASNKTHI GTLDLWQSAG LNIIAPPEGG YKDKPNNTPS QSGTKNDKNE
360 370 380 390 400
SAKNDKQESA QNNSNTQVIN PPNSAQKTEI QPTQVIDGPF AGGKDTVVNI
410 420 430 440 450
NRINTKADGT IRVGGYKASL TTNAAHLHIG KGGVNLSNQA SGRSLLVENL
460 470 480 490 500
TGNITVDGPL RVNNQVGGYA LAGSSANFEF KAGTDTKNGT ATFNNDISLG
510 520 530 540 550
RFVNLKVDAH TANFKGIDTG NGGFNTLDFS GVTGKVNINK LITASTNVAV
560 570 580 590 600
KNFNINELIV KTNGVSVGEY THFSEDIGSQ SRINTVRLET GTRSIFSGGV
610 620 630 640 650
KFKSGEKLVI DEFYYSPWNY FDARNIKNVE ITRKFASSTP EKPLGTSKLM
660 670 680 690 700
FNNLTLGQNA VMDYSQFSNL TIQGDFINNQ GTINYLVRGG KVATLNVGNA
710 720 730 740 750
AAMMFNNDID SATGFYKPLI KINSAQDLIK NTEHVLLKAK IIGYGNVSTG
760 770 780 790 800
TNGISNVNLE EQFKERLALY NNNNRMDTCV VRNTDDIKAC GMAIGNQSMV
810 820 830 840 850
NNPDNYKYLI GKAWRNIGIS KTANGSKISV YYLGNSTPTE NGGNTTNLPT
860 870 880 890 900
NTTNNARSAN YALVKNAPFT HSATPNLVAI NQHDFGTIES VFELANRSKD
910 920 930 940 950
IDTLYTHSGA QGRDLLQTLL IDSHDAGYAR QMIDNTSTGE ITKQLNAATD
960 970 980 990 1000
ALNNVASLEH KTSGLQTLSL SNAMILNSRL VNLSRRHTNH INSFAQRLQA
1010 1020 1030 1040 1050
LKGQRFASLE SAAEVLYQFA PKYEKPTNVW ANAIGGASLN NGSNASLYGT
1060 1070 1080 1090 1100
SAGVDAYLNG NVEAIVGGFG SYGYSSFSNQ ANSLNSGANN TNFGVYSRIF
1110 1120 1130 1140 1150
ANQHEFDFEA QGALGSDQSS LNFKSALLQD LNQSYNYLAY SAATRASYGY
1160 1170 1180 1190 1200
DFAFFRNALV LKPSVGVSYN HLGSTNFKSN STNQVALKNG SSSQHLFNAS
1210 1220 1230 1240 1250
ANVEARYYYG DTSYFYMNAG VLQEFANFGS SNAVSLNTFK VNAARNPLNT
1260 1270 1280 1290
HARVMMGGEL QLAKEVFLNL GVVYLHNLIS NIGHFASNLG MRYSF
Length:1,295
Mass (Da):139,809
Last modified:May 1, 1999 - v2
Checksum:iB4B7F7AEF7901CB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071095 Genomic DNA. Translation: AAC77450.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071095 Genomic DNA. Translation: AAC77450.1.

3D structure databases

ProteinModelPortaliO34110.
SMRiO34110. Positions 396-852.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan."
    Ito Y., Azuma T., Ito S., Miyaji H., Hirai M., Yamazaki Y., Sato F., Kato T., Kohli Y., Kuriyama M.
    J. Clin. Microbiol. 35:1710-1714(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F37Imported.
  2. "Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori."
    Ito Y., Azuma T., Ito S., Suto H., Miyaji H., Yamazaki Y., Kohli Y., Kuriyama M.
    J. Infect. Dis. 178:1391-1398(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F37Imported.

Entry informationi

Entry nameiO34110_HELPX
AccessioniPrimary (citable) accession number: O34110
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: May 1, 1999
Last modified: December 9, 2015
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.