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O34098

- SPOT_SPICI

UniProt

O34098 - SPOT_SPICI

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Protein
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Gene
spoT
Organism
Spiroplasma citri
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Manganese By similarity.

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
  3. metal ion binding Source: InterPro
  4. phosphoric diester hydrolase activity Source: InterPro

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00908; UER00886.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
Alternative name(s):
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:spoT
OrganismiSpiroplasma citri
Taxonomic identifieri2133 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesSpiroplasmataceaeSpiroplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
PRO_0000166575Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO34098.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 148100HD
Add
BLAST
Domaini674 – 74976ACT
Add
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 ACT domain.
Contains 1 HD domain.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34098-1 [UniParc]FASTAAdd to Basket

« Hide

MDRDIKYEEV LAQIKLYIKD EATLKEIQKA YEYAEEKHHG QVRNSGARYI    50
IHPLWTTFFL AQWRMGPKTL IAGLLHDVLE DTPATFEELQ ELFGIEIANL 100
VEGVTKVSYF AKENRTQIKA QYLRKLYLSM AKDIRVIIVK LADRLHNLKT 150
IGYLKPERQQ IIARESLEIY SAIAHRLGMK AVKQEIEDIS FKIINPVQYN 200
KIVSLLESSN KERENTINQK IEELKKILIT EKKMSVKVYG RSKSIYSIYR 250
KMNQFGKNFD DIHDILAVRI ITNSVDDCYK VLGFVHQHYT PLNNRFKDYI 300
ATPKHNLYQS LHTTIVADDG LIFEVQIRTE EMDELAEQGV AAHWRYKEGE 350
NYDIAKKQKD IDERLDIFKR ILDLENISVQ ERDEIQQEVY KPDHLMEQII 400
QNDIFSSLIY VLTPNGKVVT LPFGSTVLDF AYKIHSEIGE KTIGAKINGL 450
FSPISTVLKS GDVVDIKTAA TQKPNHSWLV VSKTSSALEK IKKYLKKELV 500
EVTSDAKSVN LEKIKQTKSQ IEEYIAKKDL KWKLVNSETQ LERLHAINFN 550
NIEDFLLDVA NDEYTLEEAI NLVYLDHETS QNEKILKKLQ DKQYKKAQLK 600
DDIIVQGISN IKVVISQCCL PIPYEDITGY VSKAEGIKVH LKTCRNIQSG 650
DKQDRQVEVS WNEAVCKNKQ YDCAIRIEAI DRPALLVDVT KVLSHLNASV 700
QMMSANVSGD LMNLTIKTII KVSNADRLQQ IRSSLLTIPD IKVVERVMM 749
Length:749
Mass (Da):86,282
Last modified:January 1, 1998 - v1
Checksum:iD32992E612317042
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89875 Genomic DNA. Translation: AAC45548.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89875 Genomic DNA. Translation: AAC45548.1 .

3D structure databases

ProteinModelPortali O34098.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00886 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, characterization, and complementation of a motility mutant of Spiroplasma citri."
    Jacob C., Nouzieres F., Duret S., Bove J.M., Renaudin J.
    J. Bacteriol. 179:4802-4810(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GII-3.

Entry informationi

Entry nameiSPOT_SPICI
AccessioniPrimary (citable) accession number: O34098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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