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O34098

- SPOT_SPICI

UniProt

O34098 - SPOT_SPICI

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Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Gene

spoT

Organism
Spiroplasma citri
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Manganese.By similarity

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00908; UER00886.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
Alternative name(s):
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:spoT
OrganismiSpiroplasma citri
Taxonomic identifieri2133 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesSpiroplasmataceaeSpiroplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolasePRO_0000166575Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO34098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 148100HDAdd
BLAST
Domaini674 – 74976ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 HD domain.Curated

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O34098-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRDIKYEEV LAQIKLYIKD EATLKEIQKA YEYAEEKHHG QVRNSGARYI
60 70 80 90 100
IHPLWTTFFL AQWRMGPKTL IAGLLHDVLE DTPATFEELQ ELFGIEIANL
110 120 130 140 150
VEGVTKVSYF AKENRTQIKA QYLRKLYLSM AKDIRVIIVK LADRLHNLKT
160 170 180 190 200
IGYLKPERQQ IIARESLEIY SAIAHRLGMK AVKQEIEDIS FKIINPVQYN
210 220 230 240 250
KIVSLLESSN KERENTINQK IEELKKILIT EKKMSVKVYG RSKSIYSIYR
260 270 280 290 300
KMNQFGKNFD DIHDILAVRI ITNSVDDCYK VLGFVHQHYT PLNNRFKDYI
310 320 330 340 350
ATPKHNLYQS LHTTIVADDG LIFEVQIRTE EMDELAEQGV AAHWRYKEGE
360 370 380 390 400
NYDIAKKQKD IDERLDIFKR ILDLENISVQ ERDEIQQEVY KPDHLMEQII
410 420 430 440 450
QNDIFSSLIY VLTPNGKVVT LPFGSTVLDF AYKIHSEIGE KTIGAKINGL
460 470 480 490 500
FSPISTVLKS GDVVDIKTAA TQKPNHSWLV VSKTSSALEK IKKYLKKELV
510 520 530 540 550
EVTSDAKSVN LEKIKQTKSQ IEEYIAKKDL KWKLVNSETQ LERLHAINFN
560 570 580 590 600
NIEDFLLDVA NDEYTLEEAI NLVYLDHETS QNEKILKKLQ DKQYKKAQLK
610 620 630 640 650
DDIIVQGISN IKVVISQCCL PIPYEDITGY VSKAEGIKVH LKTCRNIQSG
660 670 680 690 700
DKQDRQVEVS WNEAVCKNKQ YDCAIRIEAI DRPALLVDVT KVLSHLNASV
710 720 730 740
QMMSANVSGD LMNLTIKTII KVSNADRLQQ IRSSLLTIPD IKVVERVMM
Length:749
Mass (Da):86,282
Last modified:January 1, 1998 - v1
Checksum:iD32992E612317042
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89875 Genomic DNA. Translation: AAC45548.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89875 Genomic DNA. Translation: AAC45548.1 .

3D structure databases

ProteinModelPortali O34098.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00886 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, characterization, and complementation of a motility mutant of Spiroplasma citri."
    Jacob C., Nouzieres F., Duret S., Bove J.M., Renaudin J.
    J. Bacteriol. 179:4802-4810(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GII-3.

Entry informationi

Entry nameiSPOT_SPICI
AccessioniPrimary (citable) accession number: O34098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3