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Protein

RNA polymerase sigma factor RpoD

Gene

rpoD

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi640 – 659H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, Sigma factorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor RpoDUniRule annotation
Alternative name(s):
Sigma-70UniRule annotation
Gene namesi
Name:rpoDUniRule annotationImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO33992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini469 – 482RNA_pol_sigma70InterPro annotationAdd BLAST14
Domaini639 – 665RNA_pol_sigma70InterPro annotationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni445 – 515Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni524 – 600Sigma-70 factor domain-3UniRule annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 59Sequence analysisAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi469 – 472Interaction with polymerase core subunit RpoCUniRule annotation4

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105DG1. Bacteria.
COG0568. LUCA.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00963. Sigma70_RpoD_SigA. 1 hit.
InterProiView protein in InterPro
IPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012760. RNA_pol_sigma_RpoD_C.
IPR028630. Sigma70_RpoD.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02393. RpoD_Cterm. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiView protein in PROSITE
PS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O33992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKANEEKA PKRAKQEAKA EATQEIKQEN KTKESNKAKE SKIKENKTKE
60 70 80 90 100
SKIKEAKAKE PIPVKKLSFN EALEELFANS LSDCVSYESI IQISAKVPAL
110 120 130 140 150
AQVKKIKELC QKYQKKLVSS SEYAKKLNAI DKIKNTEEKQ KVLDEELEDG
160 170 180 190 200
YDFLKEKDFL EWSRSDSPVR MYLREMGDIK LLSKDEEIEL SKQIRLGEDI
210 220 230 240 250
ILDAICSVPY LIDFIYAYKD ALINRERRVK ELFRSFDDDD ENSVSDSKKD
260 270 280 290 300
DDSEEDEENE ERKKVVSEKD KKRVEKVQES FKALDKAKKE WLKALEAPID
310 320 330 340 350
EKEDELVRSL TLAYKRQILK DRLYDLEPTS KLINELVKTM ETTLKSGDGF
360 370 380 390 400
EKELKRLEYK LPLFNDVLIA NHKKILANIT NMTKEDIIAQ VPEATMVSVY
410 420 430 440 450
MDLKKLFLTK EASEEGFDLA PNKLKEILEQ IKRGKLISDR AKNKMAKSNL
460 470 480 490 500
RLVVSIAKRF TSRGLPFLDL IQEGNIGLMK AVDKFEHEKG FKFSTYATWW
510 520 530 540 550
IKQAISRAIA DQARTIRIPI HMIDTINRIN KVMRKHIQET GKEPDLEVVA
560 570 580 590 600
EEVGLSLDKV KNVIKVTKEP ISLETPVGND DDGKFGDFVE DKNIVSSIDH
610 620 630 640 650
IMREDLKAQI ESVLDQLNER EKAVIRMRFG LLDDESERTL EEIGKELNVT
660 670 680
RERVRQIESS AIKKLRSPQY GRILRNYLRI
Length:680
Mass (Da):78,690
Last modified:January 1, 1998 - v1
Checksum:iEB6C65A45F592061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83703 Genomic DNA. Translation: AAB81010.1.

Similar proteinsi

Entry informationi

Entry nameiO33992_HELPX
AccessioniPrimary (citable) accession number: O33992
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation